Ask about this productRelated genes to: NFKBIA Blocking Peptide
- Gene:
- NFKBIA NIH gene
- Name:
- NFKB inhibitor alpha
- Previous symbol:
- NFKBI
- Synonyms:
- IKBA, MAD-3, IkappaBalpha
- Chromosome:
- 14q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1992-02-13
- Date modifiied:
- 2019-04-23
Related products to: NFKBIA Blocking Peptide
Related articles to: NFKBIA Blocking Peptide
- As cannabis use continues to rise among people with HIV (PWH), understanding its impact on immune function in this population is becoming increasingly important. To provide new insights on how cannabis modulates immune function, we analyzed single-nucleus multi-omic profiles of peripheral blood mononuclear cells (PBMCs) from PWH to characterize the changes in gene expression and chromatin accessibility associated with chronic cannabis exposure. We identified numerous differentially expressed genes (DEGs) between cannabis users and non-users in each cell type, approximately half of which were unique to individual cell types. Changes in pro- and anti-inflammatory gene expression associated with cannabis use are dependent on cell lineage and type. We identified hundreds of differential chromatin accessibility regions in each cell type, including -regulatory elements correlated with cell-type-dependent DEGs (e.g. in CD4+ T cells and in classical monocytes). Multiple cannabis-associated transcription factors (e.g., , and ) emerge as regulators of the differentially expressed inflammatory genes. Furthermore, cannabis altered the communication between classical monocytes and lymphocytes. These findings indicate that cannabis-induced immunomodulatory effects are profound, dynamic and complex among cell types and that transcriptional changes are regulated at least in part by epigenetic mechanisms. - Source: PubMed
Publication date: 2026/02/27
Li MingruiAsam KesavaDuan XiaokePage Grier PHu YingMartinez ClaudiaCohen Mardge HArchin Nancie MValizadeh AmirHancock Dana BJohnson EricAouizerat Bradley EXu Ke - Major traumatic life events are risk factors for stress-related neuropsychiatric disorders, often accompanied by systemic inflammation, neuroinflammation, and microglial priming. As systemic inflammation, neuroinflammation, and microglial priming are considered risk factors for developing stress-related psychiatric disorders, one novel therapeutic strategy is to identify interventions that mitigate these responses. In this study, we investigated the effects of a novel soil-derived Mycolicibacterium, Mycolicibacterium sp. strain KGA-10, on in vitro immunoregulatory potential in murine bone marrow-derived dendritic cells (BMDCs) and on biomarkers of systemic inflammation, biomarkers of hippocampal neuroinflammation and microglial priming, and anxiety-like defensive behavioral responses in adult male rats exposed to inescapable tail-shock stress (IS). In Experiments 1, 2, and 3, BMDCs were exposed to the type strain, Mycolicibacterium vaccae ATCC 15483 (0, 10, 30, 100, 300 µg/mL; Experiment 1) or M. sp. strain KGA-10 (100 µg/mL; Experiments 2 and 3) or sterile borate-buffered saline (BBS) vehicle followed, 24 h later, by exposure to lipopolysaccharide (LPS; 250 ng/mL) or a cell culture media vehicle, then, 24 h later, assessed for Il10, Il12a, and Il12b mRNA expression. Exposure of murine BMDCs to M. vaccae ATCC 15483 or M. sp. strain KGA-10 induced an immunoregulatory phenotype, characterized by increased ratios of Il10:Il12a and Il10:Il12b mRNA expression in both naïve and lipopolysaccharide- (LPS; 250 ng/mL) challenged conditions. In Experiment 3, adult male rats received weekly injections of heat-killed M. sp. strain KGA-10 (0.1 mg/0.1 mL, s.c.) or sterile BBS vehicle over three weeks prior to IS. Anxiety-like defensive behavioral responses were assessed 24 h following IS or home cage control conditions using the juvenile social exploration (JSE) test, while biomarkers of hippocampal neuroinflammation and microglial priming were assessed using real-time reverse transcription - polymerase chain reaction (real-time RT-PCR). M. sp. strain KGA-10 treatment promoted an anti-inflammatory immunophenotype, evidenced by decreased hippocampal Il12a, and decreased biomarkers of microglial priming, Nfkbia and Nlrp3 mRNA expression among rats exposed to IS, in association with prevention of IS-induced increases in anxiety-like defensive responses in the JSE test. These findings suggest that M. sp. strain KGA-10 is a promising candidate for a novel intervention for promotion of stress resilience and prevention of stress-related psychiatric disorders. - Source: PubMed
Publication date: 2026/05/11
Zhang HaotingMarquart Brandon MHolbrook Evan MWright Caelan T OZambrano Cristian AGebert Matthew JDawud Lamya'a MAndersen Nathan DKessler Lyanna RSago Saydie ACole Echo YCostanza-Chavez Gabriel WBaratta Michael VFrank Matthew GMacDonald Andrew SStamper Christopher EBohr Adam DFierer NoahLowry Christopher A - Inflammation and oxidative stress are closely linked pathological processes, characterized by the excessive generation of reactive oxygen species, which activate redox-sensitive transcription factors, initiating a cascade of pro-inflammatory cytokine release that sustains cellular and tissue damage. This study examined two bioactive compounds derived from Symplocos sumuntia Buch-Ham. ex D Don for their anti-inflammatory properties. Network pharmacology analysis proposed RELA, NFKBIA, and PTGS2 as critical molecular targets, suggesting the suppression of pro-inflammatory cytokines through the NF-κB pathway. Phytochemical profiling showed that the crude extract and ETOAc fraction contained high phenolic compounds. Additionally, in vitro and in silico studies further substantiated the antioxidant properties of this plant. These findings highlight the dual anti-inflammatory and antioxidant properties of S. sumuntia, affirming its potential as a natural therapeutic candidate for inflammatory disorders. A validated HPLC-MS method was established to qualify active ingredients, which made utilization of the quality of S. sumuntia-based products on the market by controlling the content of these active constituents. Our study characterized the anti-inflammatory potentials of this plant through assessing the anti-inflammatory mechanisms of its active ingredients and highlighted that this plant might be a promising candidate for the development of anti-inflammatory and antioxidant products. - Source: PubMed
Huong Tran ThuQuang Tran AnhVan Thong NguyenThuy Le ThiMai Nguyen Thi HoangMinh Nguyen HoangHiep Nguyen TuanHuy Nguyen QuocHien Phan Phuoc - Periodontitis (PD) is a prevalent chronic inflammatory disorder in adults, and moderate-to-severe PD (Stage II-III/IV) may accelerate brain aging and neurodegenerative changes via the peripheral-central immune-neural axis, although the molecular connections and mechanisms of interaction have yet to be fully elucidated. This study sought to identify senescence-associated molecules potentially shared by PD and Alzheimer's disease (AD) using integrated transcriptomic analysis, machine learning, and RNA interference assays, and to further assess the role of TMEM140 in linking PD to brain aging. - Source: PubMed
Publication date: 2026/04/22
Zhao HaoRanWang HongTaoLi WangXingSu RuiLi JingLiu YanWang Lei - The purpose of this study is to identify hub genes associated with both osteoporosis (OP) and chronic kidney disease (CKD) through bioinformatics analysis, and to explore the potential pathogenetic mechanisms in OP and CKD through these hub genes. - Source: PubMed
Publication date: 2026/05/04
Tang HaoHu KaiHe YuankangZhang ZihaoLiu BingchengMa XiaoYe Tianwen