Ask about this productRelated genes to: Bend6 Blocking Peptide
- Gene:
- BEND6 NIH gene
- Name:
- BEN domain containing 6
- Previous symbol:
- C6orf65
- Synonyms:
- FLJ30162, bA203B9.1
- Chromosome:
- 6p12.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-05-07
- Date modifiied:
- 2014-11-18
Related products to: Bend6 Blocking Peptide
Related articles to: Bend6 Blocking Peptide
- Insect bite hypersensitivity (IBH) is a prevalent allergic skin disease in horses that significantly affects animal welfare and shows evidence of genetic predisposition. - Source: PubMed
Publication date: 2026/03/20
Błaszczak AOlczak KStefaniuk-Szmukier MTomczyk-Wrona IMusiał A DGrzegorczyk JDługosz BSzmatoła TRopka-Molik K - Innate immunity serves as a crucial defense mechanism against invading pathogens, yet its negative regulatory network remains under explored. In this study, we identify BEN domain-containing protein 6 (BEND6) as a novel negative regulator of innate immunity through a genome-scale CRISPR knockout screen for host factors essential for viral replication. We show that BEND6 exhibits characteristics of an interferon-stimulated gene (ISG), with its mRNA and protein levels upregulated by RNA virus-induced IFN-β. BEND6 targets IRF3 and inhibits its recruitment by TBK1, thus preventing IRF3 phosphorylation and dimerization. Additionally, BEND6 directly binds to ISRE, thereby hindering the DNA binding activity of IRF3 and blocking the subsequent activation of IFN-β transcription. Taken together, our study reveals the mechanism of BEND6 in promoting the replication of various RNA viruses and provides a potential therapeutic target for RNA virus infection. - Source: PubMed
Publication date: 2025/01/10
Chen TongDing LingTu ShaoyuSun HuiminZou JiahuiOuyang AotianJiang MeijunFeng YiJin MeilinChen HuanchunZhou Hongbo - The BEN domain-containing transcription factors regulate transcription by recruiting chromatin-modifying factors to specific chromatin regions via their DNA-binding BEN domains. The BEN domain of BANP has been shown to bind to a CGCG DNA sequence or an AAA-containing matrix attachment regions DNA sequence. Consistent with these in vivo observations, we identified an optimal DNA-binding sequence of AAATCTCG by protein binding microarray, which was also confirmed by our isothermal titration calorimetry and mutagenesis results. We then determined crystal structures of the BANP BEN domain in apo form and in complex with a CGCG-containing DNA, respectively, which revealed that the BANP BEN domain mainly used the electrostatic interactions to bind DNA with some base-specific interactions with the TC motifs. Our isothermal titration calorimetry results also showed that BANP bound to unmethylated and methylated DNAs with comparable binding affinities. Our complex structure of BANP-mCGCG revealed that the BANP BEN domain bound to the unmethylated and methylated DNAs in a similar mode and cytosine methylation did not get involved in binding, which is also consistent with our observations from the complex structures of the BEND6 BEN domain with the CGCG or CGmCG DNAs. Taken together, our results further elucidate the elements important for DNA recognition and transcriptional regulation by the BANP BEN domain-containing transcription factor. - Source: PubMed
Publication date: 2023/04/20
Liu KeZhang JinXiao YuqingYang AllySong XiaoshengLi YanjunChen YunxiaHughes Timothy RMin Jinrong - Form deprivation myopia (FDM) is an urgent public issue characterized by pathological changes, but the underlying mechanism remained unclear. The aim was to investigate bone morphogenetic proteins (BMPs) utilizing the pathogenesis of FDM. - Source: PubMed
Publication date: 2022/04/18
Chen Chun-WenYao Jing-Yan - Fat traits are important in the chicken industry where there is a desire for high intramuscular fat (IMF) and low abdominal fat. However, there is limited knowledge on the relationship between the dynamic status of gene expression and the body fat deposition in chicken. Transcriptome data were obtained from breast muscle and abdominal fat of female chickens from nine developmental stages (from embryonic day 12 to hatched day 180). In total, 8,545 genes in breast muscle and 6,824 genes in abdominal fat were identified as developmentally dynamic genes. Weighted correlation network analysis was used to identify gene modules and the hub genes. Twenty-one hub genes were identified, e.g., , which represents a candidate for high IMF, and , which relates to low abdominal fat weight. The transcript factor and the transcript factor cofactors , , and related to both high breast muscle IMF and low abdominal fat weight. Our results provide a resource of developmental transcriptome profiles in chicken breast muscle and abdominal fat. The candidate genes can be used in the selection for increased IMF content and/or a decrease in abdominal fat weight which would contribute to the improvement of these traits. - Source: PubMed
Publication date: 2020/08/28
Xing SiyuanLiu RanranZhao GuipingLiu LuGroenen Martien A MMadsen OleZheng MaiqingYang XintingCrooijmans Richard P M AWen Jie