Ask about this productRelated genes to: GADD45B Blocking Peptide
- Gene:
- GADD45B NIH gene
- Name:
- growth arrest and DNA damage inducible beta
- Previous symbol:
- MYD118
- Synonyms:
- GADD45BETA, DKFZP566B133
- Chromosome:
- 19p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1994-01-10
- Date modifiied:
- 2015-11-16
Related products to: GADD45B Blocking Peptide
Related articles to: GADD45B Blocking Peptide
- Osteoarthritis (OA), intervertebral disc degeneration (IVDD), and ligamentum flavum hypertrophy (LFH) frequently manifest concurrently in the aging population. This study aims to identify potential diagnostic genes associated with these three interconnected conditions. - Source: PubMed
Publication date: 2026/04/29
Han WeiqiDeng ZhiboLin ZhaoLuo JunXu Jie - Wilms tumor (WT) is the most common pediatric kidney cancer. Tolerogenic dendritic cells (TolDCs) promote tumor immune evasion in the tumor microenvironment. Therefore, establishing a TolDC-based prognostic model for WT holds significant clinical value. We analyzed WT-related genes from The Cancer Genome Atlas and TolDC-associated datasets to identify shared differentially expressed genes using Venn analysis. Protein-protein interaction network analysis and machine learning algorithms (Boruta and Support Vector Machine Recursive Feature Elimination, SVM-RFE) were performed to screen candidate hub genes. A prognostic risk model was constructed using univariate Cox proportional hazards regression, with predictive performance evaluated by Kaplan-Meier survival analysis and receiver operating characteristic curves. Immune infiltration analysis, gene set enrichment analysis, and BioGRID were conducted to elucidate biological functions. Drug-gene interaction analysis was performed using the Drug Signature Database. A total of 181 co-expressed genes were identified. Among these, MSH2, CDH2, ALDH1A1, AURKA, CD274, FOSL2, IL15RA, GADD45B, TGM2, CXCR4, SOD2, and MT1E were selected as TolDC-associated biomarkers for WT. The prognostic model ultimately pinpointed ALDH1A1, CXCR4, and FOSL2 as key diagnostic biomarkers, supported by Kaplan-Meier survival analysis and ROC curves, which confirmed the model's robust predictive capacity for survival risk. Drug-gene interaction analysis predicted 335 potential therapeutic compounds targeting ALDH1A1, CXCR4, and FOSL2. Comprehensive bioinformatics analysis identified the prognostic biomarkers of WT related to TolDCs, providing new insights for personalized WT treatment. - Source: PubMed
Publication date: 2026/04/30
Sun XiaolanGao YaqingMeng KexinWang YixuanWang Bei - The liver has a unique capacity for self-renewal, maintaining a proper liver-to-bodyweight ratio, which is essential for sustaining homeostasis. Regenerative process in the liver involves intricate communication between various cell types such as hepatocytes, hepatic stellate cells, endothelial cells, and inflammatory cells. Although the role of endothelial cells in liver regeneration has been extensively studied, detailed knowledge regarding specific endothelial cell-derived factors that promote the regeneration of liver endothelial cells (LECs) remains limited. This study aimed to identify the regenerative capacity of endothelial progenitor cells (EPCs) after acute liver injury. - Source: PubMed
Publication date: 2026/03/28
Lee Jong-MinHa Yoon-SuLee Seung-JunKim Hyun-YiAdpaikar Anish AshokKim Eun-JungOtsu KeishiChe XiangguoHan Dai HoonHer YoungChoi Je-YongKim Seung-JinJung Han-Sung - Despite advances in acute ischemic stroke (AIS) research, identifying reliable biomarkers and regulatory mechanisms remains challenging. We first identified AIS-related genes via extensive literature review, retrieved dataset GSE16561 from the Gene Expression Omnibus (GEO, https://ncbi.nlm.nih.gov/geo/), and performed differential/enrichment analyses. Bioinformatics verified N6-methyladenosine (mA) sites in target genes, focusing on the methyltransferase-like protein 14 (METTL14)/growth arrest and DNA damage-inducible β (GADD45B) mA methylation/brain-derived neurotrophic factor (BDNF) axis. Peripheral blood samples, biochemical indicators, and demographic data were collected from Hongqi Hospital Affiliated to Mudanjiang Medical University. Human umbilical vein endothelial cells (HUVECs) underwent transfection and oxygen-glucose deprivation (OGD). METTL14, GADD45B, and BDNF were detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR); BDNF protein by enzyme-linked immunosorbent assay (ELISA); global RNA mA by Dot Blot; and GADD45B mA by methylated RNA immunoprecipitation-quantitative polymerase chain reaction (MeRIP-RT-qPCR). Differential, diagnostic efficacy, logistic regression analyses, and nomogram validation were conducted. AIS patients showed increased METTL14, decreased GADD45B/BDNF, and increased levels of global mA RNA and GADD45B mA RNA (P < 0.05). Receiver operating characteristic (ROC) analysis confirmed the three genes' good diagnostic efficacy. The nomogram integrating these genes, globulin (GLOB), diabetes, high-density lipoprotein cholesterol (HDL-C), and hypertension performed excellently. This study highlights METTL14, GADD45B, and BDNF as key AIS biomarkers; METTL14 may indirectly regulate BDNF via GADD45B mA methylation, providing potential therapeutic targets and novel mechanistic insights. - Source: PubMed
Publication date: 2026/04/16
Lai Jin-YingLu Jun-HuaLi Meng-YueLi Bei-BeiJin Bao-YunHao Jiang-JieZhao YingLin YingMa Li-QiuLiu RenZhang Shu-FanGuan Hong-Jun - To explore the regulatory aspects of mRNAs and miRNAs in suicide, we integrated transcriptomic data from GEO datasets. The analysis of mRNA expression in the prefrontal cortex of suicide victims with major depressive disorder revealed a differential profile with 27 downregulated mRNAs, including , , , , and , which are involved in proteostasis, transcriptional regulation, and apoptosis. Functional enrichment analysis using KEGG and Gene Ontology (GO) revealed significant associations with synaptic plasticity, neuronal survival, and signaling pathways, including MAPK, TGF-β, Wnt, p53, and neurotrophins. Subsequently, using the GSE34120 GEO dataset of miRNAs from the frontal cortex of suicide victims, 105 dysregulated miRNAs were identified. The networks revealed compact regulatory modules with hsa-miR-576-3p, hsa-miR-493, and hsa-miR-550, as well as highly connected central nodes such as hsa-miR-30b, hsa-miR-16a-5p, hsa-miR-181a-5p, and hsa-miR-184. The integration of both profiles allowed the elaboration of miRNA-mRNA regulatory networks in which , , , and interact with multiple dysregulated miRNAs. These findings support the notion that suicide involves complex post-transcriptional dysregulation, particularly related to astrocytic function and neurotrophic signaling, with potential diagnostic and therapeutic applications. - Source: PubMed
Publication date: 2026/03/30
Cortéz-Sánchez José LuisRivera-Escobar Hernán MauricioMuñoz Roa Esther NataliaZabala-Bello Carlos AndrésPérez-Sánchez GilbertoChin Chan José MiguelBautista-Ortiz MonserratLópez-Martínez Karla MaríaOsorio-Antonio FedericoGálvez-Romero José LuisCarrasco Carballo AlanSedeño-Monge VirginiaCastelán FranciscoBautista-Rodríguez Elizabeth