Ask about this productRelated genes to: ZNF707 Blocking Peptide
- Gene:
- ZNF707 NIH gene
- Name:
- zinc finger protein 707
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 8q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-09-23
- Date modifiied:
- 2016-06-14
Related products to: ZNF707 Blocking Peptide
Related articles to: ZNF707 Blocking Peptide
- Dysregulation of transcription factors potentiates cancer cell proliferation, stemness, cellular plasticity, metastasis, and therapy resistance and also links with diagnosis/prognosis of the diseases. Thus, investigation of uncharacterized transcription factors is a prime aim for designing novel therapeutics. Large family C2H2 type zinc finger proteins (ZNFs) often bind to nucleic acids and also act as transcription factors. However, unregulated expression of these ZNFs was found to cause diverse pathological conditions including cancer. - Source: PubMed
Mahapatra Manas KBansal ShivaniMakwana Sweta HGhosh SudipNag AloShrivastava Sandeep KMaheshwari RekhaMandal Chandi C - Ovarian clear cell adenocarcinoma (Ov-CCA) has a higher prevalence in the Japanese ancestry than other populations. The ancestral disparities in Ov-CCA prevalence suggests the presence of Ov-CCA-specific genetic alterations and may provide an opportunity to identify the novel genes associated with Ov-CCA tumorigenesis. Using 94 previously reported genes as the phenotypic trait, we conducted multistep expression quantitative trait loci (eQTL) analysis with the HapMap3 project datasets. Four single-nucleotide polymorphisms (SNPs) (rs4873815, rs12976454, rs11136002, and rs13259097) that had different allele frequencies in the Japanese ancestry and seven genes associated in (, , , , , , and ) were identified. In silico functional annotation analysis and in vitro promoter assay validated the regulatory effect of rs4873815-TT on and rs11136002-TT on . Furthermore, was highly expressed in Ov-CCA and had a negative prognostic value in disease recurrence in our sample cohort. This prognostic power was consistently observed in The Cancer Genome Atlas (TCGA) clear cell renal cell carcinoma dataset, suggesting that may have prognostic value in clear cell histology regardless of tissue origin. In conclusion, rs4873815-TT/ may have clinical significance in the prognosis and tumorigenesis of Ov-CCA, which may be more relevant to clear cell histology. Besides, this study may underpin the evidence that -eQTL analysis based on ancestral disparities can facilitate the discovery of causal genetic alterations in complex diseases, such as cancer. - Source: PubMed
Publication date: 2020/04/16
Kim JihyeChung Joon-YongHwang Jae RyoungLee Yoo-YoungKim Tae-JoongLee Jeong-WonKim Byoung-GieBae Duk-SooChoi Chel HunHewitt Stephen M - Hundreds of genetic variants are thought to contribute to variation in asthma risk by modulating gene expression. Methods that increase the power of genome-wide association studies (GWASs) to identify risk-associated variants are needed. - Source: PubMed
Publication date: 2016/08/20
Ferreira Manuel A RJansen RickWillemsen GonnekePenninx BrendaBain Lisa MVicente Cristina TRevez Joana AMatheson Melanie CHui JennieTung Joyce YBaltic SvetlanaLe Souëf PeterMontgomery Grant WMartin Nicholas GRobertson Colin FJames AlanThompson Philip JBoomsma Dorret IHopper John LHinds David AWerder Rhiannon BPhipps Simon - Prostate tumors express antigens that are recognized by the immune system in a significant proportion of patients; however, little is known about the effect of standard treatments on tumor-specific immunity. Radiation therapy induces expression of inflammatory and immune-stimulatory molecules, and neoadjuvant hormone therapy causes prominent T-cell infiltration of prostate tumors. We therefore hypothesized that radiation therapy and hormone therapy may initiate tumor-specific immune responses. - Source: PubMed
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