THEX1 Blocking Peptide
- Known as:
- THEX1 Blocking Peptide
- Catalog number:
- 33r-2641
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- THEX1 Blocking Peptide
Related genes to: THEX1 Blocking Peptide
- Gene:
- ERI1 NIH gene
- Name:
- exoribonuclease 1
- Previous symbol:
- THEX1
- Synonyms:
- 3'HEXO
- Chromosome:
- 8p23.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-05-24
- Date modifiied:
- 2014-11-19
Related products to: THEX1 Blocking Peptide
Related articles to: THEX1 Blocking Peptide
- Parental age influences offspring traits across species, yet the molecular pathways by which maternal state modulates progeny neural function remain poorly defined. Here we demonstrate that maternal age in regulates progeny avoidance of the social pheromone by modulating the activity of a defined sensory circuit. Progeny of young mothers exhibit stronger activity of the pheromone-sensing ADL neurons and enhanced pheromone avoidance, whereas progeny of old mothers display reduced neuronal responses and weaker repulsion. We identify an ERI-1-microRNA-neuropeptide signaling axis operating in peptidergic AVH interneurons that modulates ADL circuit responsiveness. ERI-1 promotes expression of the neuropeptide gene by repressing , and signaling from AVH to ADL establishes pheromone sensitivity. Maternal aging is associated with reduced ERI-1 expression in progeny AVH neurons and dampening this signaling pathway. Consequently, progeny of young mothers, though developmentally less robust, disperse more readily from crowded, pheromone-rich environments, offsetting their early-life disadvantages. Our findings reveal a molecular and circuit-level mechanism by which maternal physiology adaptively configures offspring neural computation and behavioral strategy across generations. - Source: PubMed
Publication date: 2026/03/05
Hwang HyeonjeongCheon YongJinOh Seung HeeJo SujinKim Taehyun AOh EujeongHwangbo SeminKim JinkwangJeong SejooDar Abdul RoufButcher RebeccaLee Jong-ChanKim Kyuhyung - Colorectal cancer (CRC) represents a significant global health challenge. Although telomere maintenance plays a crucial role in tumorigenesis, the prognostic value and immunotherapeutic relevance of telomere maintenance genes (TMGs) in CRC remain poorly understood. In this study, relevant data were retrieved from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases. TMG scores were calculated using the single-sample gene set enrichment analysis (ssGSEA) method, and TMGs associated with prognosis were subsequently identified. TCGA-CRC samples were classified into subtypes via consensus clustering (ConsensusClusterPlus). A risk prediction model was then constructed using univariate and Lasso Cox regression analyses. Survival analysis was performed using Kaplan-Meier curves generated with the survival package. Key genes were validated in vitro using cellular models. Immune cell infiltration was evaluated through ssGSEA, TIMER, and MCP-Counter tools, and chemotherapy responses were predicted using the pRRophetic package. From 28 prognosis-related TMGs, two distinct CRC subtypes were established, with subtype C1 demonstrating more favorable clinical outcomes. Additionally, a risk model incorporating seven TMG-related genes (CDC25C, CXCL1, RTL8C, FABP4, ITLN1, MUC12, and ERI1) was developed for CRC prognosis. Differential mRNA expression levels of these genes were confirmed between CRC cell lines and normal control cells. Furthermore, silencing MUC12 suppressed CRC cell migration and invasion in vitro. Importantly, CRC patients classified as low-risk exhibited superior responses to immunotherapy, whereas high-risk patients showed increased sensitivity to conventional anti-cancer treatments. This study represents the first systematic evaluation of TMGs in CRC prognosis and immunotherapy, providing novel insights that could inform personalized therapeutic strategies. - Source: PubMed
Publication date: 2025/07/02
Wang ZhikaiZhao ChunyanHuang YifenLi Chong - Carotid artery intima-media thickness (cIMT) is a measurement of subclinical atherosclerosis that predicts future cardiovascular events, including stroke and myocardial infarction. Genome-wide association studies (GWAS) have identified only a fraction of the genetic variants associated with cIMT. We performed the largest GWAS for cIMT involving up to 131,000 individuals. For the first time, we meta-analysed a diverse range of ancestries including populations with African, Asian (Chinese), Brazilian, European, and Hispanic ancestries. Our study identified 59 independent loci (53 loci from the multi-ancestry single variant analysis of which 19 are novel, P<5×10; 6 novel in gene-based analysis from single variant analysis, P=2.6×10, 2 novel in meta-regression) associated with cIMT. Gene-based, tissue-expression and gene-set enrichment analyses revealed novel genes of potential interest and highlighted significant relationships between vascular tissues (aorta, coronary and tibial arteries) and genetic associations. We found that circulatory levels of seven proteins, including ACAN, BCAM, DUT, ERI1, APOE, FN1, and GLRX were potentially causally associated with cIMT levels. We found a strong genome-wide correlation between cIMT and various cardiometabolic, smoking phenotypes, and lipid traits. Using Mendelian randomisation, our analyses provide robust evidence for causal associations between cIMT and several clinically relevant traits, including lipids, blood pressure, and waist circumference. Our study extends our genetic knowledge of atherosclerosis and highlights potential causal relations between risk factors, atherosclerosis and clinical diagnoses. - Source: PubMed
Publication date: 2025/04/14
Meena DevendraHuang JianZare MarjanHasbani Natalie RRomuald Boua PalwendéMustafa Rimavan der Laan Sander WXu HuichunTerry James GBis Joshua CJain DeeptiPalmer Nicholette DHeard-Costa NancyMin Yuan-IGuo XiuqingYao JieTaylor Kent DTan JingyiPeralta JuanPereira Alexandre CKhan AlynaChoudhury AnanyoNewman Anne BXiang Anny HHingorani AroonFreedman Barry IO'Donnell Christopher JGiambartolomei ClaudiaHerrington David MJacobs David RKlarin DerekWang Fei FeiHeiss GerardoDoddapaneni HarshaVardhanHodis Howard NBroome JaiWilson James GBrandenburg Jean-TristanBlangero JohnKrieger Jose ESmith Josh DViaud-Martinez Karine ARyan Kathleen ALange Leslie AMontasser May EMahaney Michael CMokry MichalFornage MyriamMunroe PatriciaGibbs Richard ATracy Russell PKim Ryan WDamrauer Scott MRich Stephen SHsueh Willa AChen Yii-Der Ida Morrison Alanna CMitchell Braxton DCarr John JeffreyPsaty Bruce MBowden Donald WVasan Ramachandran SCorrea AdolfoPost Wendy SGoodarzi Mark ORaffel Leslie JCurran Joanne ERamsay MicheleRotter Jerome IElliott PaulFranceschini Norade Vries Paul STzoulaki IoannaDehghan Abbas - Ribosome biogenesis (RiboSis) is a complex process for generating ribosomes, the cellular machinery responsible for protein synthesis. Dysfunctional RiboSis can disrupt cardiac structure and function, contributing to cardiovascular diseases. This study employed a Mendelian randomization (MR) approach, integrating multi-omics data, to investigate the relationship between RiboSis-related genes and standard cardiac structure and function. - Source: PubMed
Publication date: 2025/03/05
Wei ShuxuShen RonghuaiLu XiaojiaLi XinyiHe LingbinZhang YoutiYang JiahangShu ZhouwuHuang Xianxi - The purpose of this review is to explore the multifaceted roles of the ERI1 exoribonuclease, particularly in RNA metabolism and bone development, and to address the genotype-phenotype complexity in patients and mice with ERI1 pathogenic variants. - Source: PubMed
Publication date: 2025/02/13
Liu WanqiZhu JinhuiRen KaitaoXiao DanQiang RongRabouhi NazimIkegawa ShiroCampeau Philippe MGuo Long