Ask about this productRelated genes to: RNF125 Blocking Peptide
- Gene:
- RNF125 NIH gene
- Name:
- ring finger protein 125
- Previous symbol:
- -
- Synonyms:
- FLJ20456
- Chromosome:
- 18q12.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-05-21
- Date modifiied:
- 2016-06-07
Related products to: RNF125 Blocking Peptide
Related articles to: RNF125 Blocking Peptide
- Epithelial-mesenchymal transition (EMT) and glycolysis contribute to breast cancer (BC). However, the molecular mechanisms underlying these processes require further investigation. - Source: PubMed
Publication date: 2026/07/14
Wei YanhongTang ZhaohuiLuo PengfeiChen YongjianHe ZunengTang ZhangwenLiao LinLi FangOuyang XuanyeWu MingJiang ShaohuiDing Sijuan - Accurate prediction of epidermal growth factor receptor (EGFR) mutation status in lung adenocarcinoma (LUAD) with brain metastases (BMs) is crucial for guiding targeted therapy. However, noninvasive and biologically interpretable tools remain limited. In this multicenter radiogenomic study, we analyzed a total of 1303 BMs from 421 LUAD patients across three institutions. 3435 radiomic features were extracted from T1, T2, and contrast-enhanced T1 sequences. A four-task classification framework was developed to predict EGFR mutation status (EGFR+, 19Del, L858R, or sensitizing mutation) using an adaptive LightGBM-based modeling pipeline. The models achieved excellent performance in the internal cohort (AUCs up to 0.95) and were further validated in 94 lesions with pathologically confirmed EGFR status, reaching an accuracy of 83.0%, sensitivity of 84.7%, and specificity of 80.0%. SHAP and LIME analyses revealed that shape-based radiomic features, particularly original_shape_sphericity, were the most important predictors of EGFR mutational subtypes. Then, we conducted transcriptomic analysis on 38 matched surgical specimens. Radiogenomic correlation revealed that sphericity negatively correlated with RNF125 and SLC37A2. Downstream enrichment analysis identified EGFR-associated features linked to DNA replication, sister chromatid segregation, and ERBB signaling. The study demonstrates that radiogenomic modeling, grounded in interpretable biology, holds promise as a non-invasive, clinical strategy for precision stratification of LUAD BMs. - Source: PubMed
Publication date: 2026/07/06
Deng FuxingChu XianjingShi WenXiao GangTanzhu GuilongNiu LishuiZhang ZijianZhou RongrongYang Guang - Breast cancer (BC) represents one of the leading causes of cancer-related mortality in women worldwide. Betulinic acid (BA), a naturally derived pentacyclic triterpenoid, exhibits anti-BC activity. Recent evidence implicates RNF125, a RING-domain E3 ubiquitin ligase, as a tumor suppressor. This study aimed to elucidate whether BA exerts anti-BC effects via RNF125 regulation and explored the underlying mechanisms. - Source: PubMed
Publication date: 2026/06/18
Zhang PengChang YuanYang XiaoluHe BingluMa Li - Cervical cancer (CC) is a prevalent malignancy in women; however, the efficacy of immunotherapy in this disease is suboptimal, highlighting the need for novel therapeutic targets. We found that low RNF125 expression correlated with poor prognosis in CC patients. In vitro and in vivo, RNF125 inhibited proliferation and induced apoptosis of CC cells. In immunocompetent mice, RNF125 suppressed tumor growth, increased CD8⁺ T cell infiltration, elevated IFN-γ secretion, and reduced PD-1 expression on CD8⁺ T cells. Co-culture experiments confirmed that tumor cells overexpressing RNF125 enhanced CD8⁺ T cell proliferation and function. Further mechanistic investigation revealed that RNF125 promoted CD8⁺ T cell activity by ubiquitinating and degrading PD-L1. Additionally, RNF125 was identified as a direct target of miR-574-5p. This study demonstrates that RNF125 exhibits tumor-suppressive functions in CC by enhancing anti-tumor immunity, highlighting its therapeutic potential. - Source: PubMed
Publication date: 2026/03/13
Yang DiLiu JiaGao YanGuan XinTong Rui - Activated AKT and YAP signaling have been implicated in the pathogenesis of intrahepatic cholangiocarcinoma (iCCA), but their specific roles in tumor progression and regulation of the tumor microenvironment remain unclear. - Source: PubMed
Publication date: 2026/03/04
Zhao JinqiuYang LianQin YujiaZhang YiWang TingjieWang JingwenLiao RuiGreen BenjaminCui GuofeiLiao WeitingQiao YuXu MengYang HuaFarrar ChristineLiang BingLi XiaosongXin XiaojuanLi XiangCalvisi Diego FWang XueDeng YoupingWu YanhuiChen Xin