Ask about this productRelated genes to: HELT Blocking Peptide
- Gene:
- HELT NIH gene
- Name:
- helt bHLH transcription factor
- Previous symbol:
- -
- Synonyms:
- HESL, HCM1228, Mgn, bHLHb44, MEGANE
- Chromosome:
- 4q35.1
- Locus Type:
- gene with protein product
- Date approved:
- 2008-04-21
- Date modifiied:
- 2014-11-19
Related products to: HELT Blocking Peptide
Related articles to: HELT Blocking Peptide
- In France, a priority rule called high-emergency lung transplantation (HELT) was implemented in 2007 to lower the risk of mortality while on the waitlist for LT for the sickest patients. However, allowing rapid access to LT and lowering the waitlist mortality was at the expense of worse outcomes compared with regular allocation. The aim of the study was to provide actualized data on the results of HELT in France. - Source: PubMed
Publication date: 2026/06/09
Mal HervéBacar NaissaDauriat GaelleBrioude GeoffreyBeaumont LaurenceTissot AdrienOlland AnneMaury Jean MichelJougon JacquesBrouchet LaurentLe Pimpec-Barthes FrançoiseLe Pavec JéromeLegeai CamilleKerbaul FrançoisMordant PierreSage EdouardDorent Richard - Loss of elastic recoil in emphysema causes hyperinflation of the lung tissue, stretching the respiratory muscles. Maximum inspiratory pressure (MIP) and maximum expiratory pressure (MEP) decline in severe emphysema. We hypothesized that treating hyperinflation with lung volume reduction surgery (LVRS) or via bronchoscopic lung volume reduction (BLVR) with valves could lead to improved MIP or MEP. Consecutive emphysema patients referred for treatment with LVRS or BLVR from October 2020 to June 2023 were included. We applied a mixed linear model with the different treatments as independent variables to compare MIP/MEP prior to treatment, with values at 3-month follow-up. A total of 61 patients had preoperative MIP/MEP done prior to LVRS (42) or BLVR (19) treatment. Thirty-nine also had MIP/MEP measurements at 3 months follow-up, 31 after LVRS and 8 after BLVR, respectively. There was no significant increase in MIP from baseline to follow-up in the LVRS (p = 0.37) and BLVR (p = 0.32) groups. Nor was there any difference between the BLVR and LVRS group at baseline (p = 0.12) or at follow-up (p = 0.19). Similarly, MEP values were unchanged in the BLVR and LVRS groups from preoperative level to 3-month follow-up for BLVR (p = 0.59) and for LVRS (p = 0.11). - Source: PubMed
Publication date: 2026/05/21
Lund AlberteHelt Thora WesenbergHansen Henrik JessenPerch MichaelJensen KristineHornbech KåreKalhauge AnnaPetersen René HorslebenMortensen Jann - Inappropriate antibiotic use in the community is a primary driver of antimicrobial resistance (AMR), particularly in low- and middle-income countries (LMICs) where ambulatory care, including primary healthcare (PHC) facilities, is the main point of contact. While stewardship efforts in South Africa have focused largely on prescribers and hospitals, the behavioral drivers of community antimicrobial use, specifically the , remain poorly understood. This study aimed to address this gap by applying the newly developed Community Antimicrobial Use Scale (CAMUS) to quantify the prevalence of misuse and identify potential independent sociodemographic and behavioral factors associated with inappropriate antibiotic use among ambulatory care patients in South Africa. - Source: PubMed
Publication date: 2026/03/20
Ramdas NishanaSchellack NatalieUys CorrieGodman BrianCampbell Stephen MMeyer Johanna C - : Liver function is difficult to estimate accurately. Conventional liver function tests can be normal, even in severe diseases. Dynamic liver function tests, including indocyanine green (ICG) clearance and hepatobiliary scintigraphy (HBS), are useful in adults. We aimed to evaluate the association between ICG clearance and HBS in children with liver disease and to identify liver disease markers associated with liver function measured with ICG clearance and HBS. : Children aged 0-18 years followed at Copenhagen University Hospital, Rigshospitalet between November 2015 and August 2024 were eligible for inclusion if they had acute or chronic liver disease, suspected liver disease, or previous liver transplantation (LTx). All underwent ICG clearance and HBS. : We included 131 children with a total of 200 visits. The median visit age was 11.4 [6.6; 15.6] years. The ICG-plasma disappearance rate had the strongest correlation with the hepatic extraction fraction (ρ = 0.64, < 0.001). ICG clearance and HBS were associated with liver injury, reduced synthetic function, cholestasis, cirrhosis, and portal hypertension, while only ICG clearance was associated with the portal blood flow. LTx was associated with increased HBS parameters, but not with ICG clearance. : ICG clearance and HBS are correlated, and both are associated with most conventional liver function markers. This suggests their usefulness in evaluating children with liver disease. However, further evaluation of the predictive and clinical value of ICG clearance and HBS in disease progression is needed. - Source: PubMed
Publication date: 2026/03/09
Helt Thora WesenbergNielsen JonFicerai-Garland Gabriellade Nijs RobinWinther Christina LouiseMøller SørenSetterberg ViktoriaChristensen Vibeke BrixBorgwardt Lise - To relate post-surgical feeding regimens to growth and surgical outcomes in children with biliary atresia (BA) after hepato-portoenterostomy (Kasai). - Source: PubMed
Publication date: 2026/02/23
Helt Thora Wesenbergde Kleine Ruben HJohansen Lars SøndergaardDijkstra TietieHulscher Jan B FVerkade Henkjan JChristensen Vibeke Brix