Ask about this productRelated genes to: ENPP6 Blocking Peptide
- Gene:
- ENPP6 NIH gene
- Name:
- ectonucleotide pyrophosphatase/phosphodiesterase 6
- Previous symbol:
- -
- Synonyms:
- MGC33971
- Chromosome:
- 4q35.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-11-25
- Date modifiied:
- 2014-11-19
Related products to: ENPP6 Blocking Peptide
Related articles to: ENPP6 Blocking Peptide
- Choline is an essential nutrient required for the synthesis of key molecules, such as phosphatidylcholine, sphingomyelin, acetylcholine, and S-adenosylmethionine. Choline metabolism encompasses two phases, namely the postprandial and postabsorptive states. The former enables the digestion, absorption, distribution, and storage of choline derivatives after a meal, while the latter allows the cellular utilization of choline and the mobilization of stored choline-containing molecules during fasting. Understanding choline metabolism is fundamental to the study of lipid disorders such as steatohepatitis or atherosclerosis, as well as neurodegenerative diseases, including Alzheimer's disease, and inflammatory signaling pathways. Members of the alkaline phosphatase (AP) superfamily are prominent contributors to extracellular choline metabolism. Within this family, several APs and ectonucleotide pyrophosphatases/phosphodiesterases (ENPP) members are required for physiological choline metabolism. While intestinal alkaline phosphatase (IAP) and alkaline sphingomyelinase/ENPP7 both participate in the digestion of choline-containing derivatives in the gut during the postprandial phase, circulating ENPP2, ENPP6, and tissue-nonspecific alkaline phosphatase (TNAP) act during the postabsorptive phase to generate choline. In this review we first provide a comprehensive overview of choline metabolism and then describe how APs and ENPPs have functionally and structurally co-evolved to catalyze sequential reactions within this metabolic pathway. - Source: PubMed
Publication date: 2026/04/30
Lecornu FélixDrevet Mulard EvaBessueille LaurenceGerardin DaliaRautureau Gilles Jean PhilippeBallut LionelMagne David - The EAT Lancet diet is increasingly recognized for its simultaneous benefits to human and planetary health. Its key components are known to exert anti-inflammatory and antiplatelet effects; however, the potential association between adherence to the EAT‑Lancet diet and incident venous thromboembolism (VTE), as well as the underlying biological mechanisms, remains unclear. - Source: PubMed
Publication date: 2026/04/29
He QidaSun MengtongWang YuYao JiazhenShen Yueping - Autism spectrum disorder (ASD) is a neurodevelopmental disorder (NDD) that affects about 1 in 54 children worldwide, imposing enormous economic and socioemotional burden on families and communities. Genetic studies of ASD have identified copy number variants (CNVs) and point mutations that contribute significantly to the genetic architecture, but the majority of these studies were conducted in populations unsuited for detecting autosomal recessive (AR) inheritance. However, several ASD studies in consanguineous populations point towards AR as an under-appreciated source of ASD variants. We used whole exome sequencing to look for rare variants for ASD in 115 proband-mother-father trios from populations with high rates of consanguinity, namely Pakistan, Iran, and Saudi Arabia. Consanguinity was assessed through microarray genotyping. We report 77 candidate single nucleotide variants and indels, with 62% homozygous, 22% autosomal dominant/, and 16% X-linked, in 55 trios. 56% of the variants were loss of function (LoF) or putative LoF (pLoF), and 44% nonsynonymous. We found an enrichment of homozygous variants, both in 16 genes previously reported for AR ASD and/or intellectual disability (ID) and 32 previously unreported AR candidate genes (including , , , , , , , , and ). We also identified seven candidate homozygous exonic loss CNVs. The significant enrichment for homozygous variants among individuals with high F coefficients, compared with low F, either in known or candidate AR genes, confirms that genetic architecture for ASD among consanguineous populations is different to non-consanguineous populations. Assessment of consanguinity may assist in the genetic diagnostic process for ASD. - Source: PubMed
Publication date: 2026/03/21
Harripaul RicardoRabia AnsaVasli NasimMikhailov AnnaRodrigues AshlynPastore Stephen FMuhammad TahirMadanagopal Thulasi ThiruvallurHashmi Aisha NasirTran ClintonStan CassandraAw KatherineZai Clement CAzam MaleehaMahmood SaqibHeidari AbolfazlQamar RaheelFrench LeonTripathy ShreejoyAgha ZehraIqbal MuhammadGhadami MajidSantangelo Susan LBozorgmehr BitaAl Ayadhi LailaSasanfar RoksanaMaqbool ShaziaHassan ArsalanKnowles James AAyub MuhammadVincent John B - Alzheimer's disease with psychosis (AD+P) is a subgroup of AD patients with more rapid cognitive deterioration. While our previous study showed that AD+P is associated with loss of prefrontal cortex postsynaptic density (PSD) proteins, identifying proteins in the broader cellular environment that influence PSD loss addresses a critical knowledge gap about synaptic dysfunction mechanisms in early disease stages. - Source: PubMed
Publication date: 2025/12/01
Ku T SMullett S JSui ZZeng LDing YYocum A KMacDonald MGelhaus S LKofler JSweet R A - Population stratification based on gut microbiota composition has revealed several enterotypes in humans and animals, providing valuable tools for studying the gut microbiota landscape, which is crucial for animal health and production. However, knowledge about rumen enterotype identification in sheep, its influencing factors, and its association with growth performance and host genetics remains limited. Here, we investigated host genetic effects and phenotypic landscapes of rumen bacterial enterotypes in a large sheep population. Ruminal contents from 1150 healthy sheep were analyzed using 16S rRNA gene sequencing and genus-level clustering, complemented by extensive phenotypic data covering 47 traits spanning growth, feed efficiency, meat yield, and ruminal fermentation, along with whole-genome resequencing data. We identified two distinct enterotypes: Enterotype 1 (E1), a mixture of multiple genera, and Enterotype 2 (E2), dominated by . E2 sheep exhibit superior growth and meat production performance, but lower feed efficiency and increased fat deposition. Two-part beta-regression models and co-occurrence network analyses revealed the extensive impact of enterotypes on microbial community structure, with E1 displaying a higher frequency of unique bacterial interactions. The estimated heritability of the enterotype was 0.47, and a GWAS identified five key genetic markers associated with rumen enterotype, localized to two candidate genes: and . These markers significantly influence 58 ruminal bacterial genera, including key taxa and driving genus. Overall, our data provide new insights into sheep rumen-enterotype characteristics, contributing to a better understanding of microbial interactions that are crucial for improving ruminant growth performance. - Source: PubMed
Publication date: 2025/09/17
Zhang YukunLi FadiZhang XiaoxueZhang DeyinWang Weimin