Ask about this productRelated genes to: TSHR Blocking Peptide
- Gene:
- TSHR NIH gene
- Name:
- thyroid stimulating hormone receptor
- Previous symbol:
- -
- Synonyms:
- LGR3
- Chromosome:
- 14q24-q31
- Locus Type:
- gene with protein product
- Date approved:
- 1990-03-05
- Date modifiied:
- 2019-04-23
Related products to: TSHR Blocking Peptide
Related articles to: TSHR Blocking Peptide
- We report the case of a 37-year-old woman who presented with hyperemesis gravidarum at 11 weeks of gestation. Laboratory examination revealed severe thyrotoxicosis (TSH: <0.005 μIU/mL, FT3: 12.95 pg/mL, FT4: 3.93 ng/dL) with negative anti-TSH receptor antibody, while serum human chorionic gonadotropin (hCG) was markedly elevated at 198,983 mIU/mL. She was diagnosed with gestational transient thyrotoxicosis (GTT), although the presence of thyroid-stimulating antibody raised suspicion for concomitant Graves' disease (GD). Because of severe and clinically burdensome thyrotoxic symptoms, including excessive sweating and weight loss, propylthiouracil therapy was initiated, but thyrotoxicosis recurred after 20 weeks of gestation alongside elevated serum hCG levels, prompting a switch to thiamazole. Genetic testing revealed no TSHR mutations. Postpartum, both hCG and thyroid hormone levels normalized without treatment. During the second pregnancy, she experienced a miscarriage at nine weeks. During the third pregnancy, an elective abortion was performed due to a fetal genetic disorder. Both pregnancies were marked by severe thyrotoxicosis, consistent with GTT. During the fourth pregnancy, at 11 weeks, she developed hyperemesis gravidarum and was diagnosed with GTT. The persistently elevated thyroglobulin levels (>200 ng/mL; reference range:, <33.7 ng/mL) were also compatible with a possible contribution from painless thyroiditis (PT). Serum hCG levels normalized after the second trimester. Recurrent and sustained thyrotoxicosis during pregnancy across multiple pregnancies in the same patient is rare and requires careful differentiation among possible etiologies, including GTT, GD, and PT. This case underscores the importance of comprehensive monitoring of placental function, thyroid autoimmunity, and thyroiditis throughout pregnancy to ensure accurate diagnosis and tailored management for both mother and fetus. - Source: PubMed
Publication date: 2026/06/15
Kaido YosukeMinamino HirotoInaba HidefumiKosugi DaisukeInoue GenYabe Daisuke - Estuarine ecosystems are increasingly threatened by organic ultraviolet absorbers (OUVs). However, their acute and combined toxicity to estuarine aquatic organisms at environmentally relevant concentrations remains poorly understood. This study evaluated the acute lethality and sublethal developmental toxicity of ethylhexyl salicylate (EHS), homosalate (HMS), and UV-329 on Mugilogobius chulae embryos. It also investigated the developmental effects and thyroid-related transcriptional responses of binary and ternary mixtures at environmentally relevant concentrations, and assessed their combined effects at both phenotypic and transcriptional levels. While individual exposure exhibited low acute lethality, co-exposure to binary and ternary mixtures increased embryonic mortality, although these changes were not statistically significant. Co-exposure significantly decreased embryonic heart rate (p < 0.05). Notably, at the tested environmentally relevant concentration, the heart rate response to the HMS + UV-329 mixture showed an interaction pattern consistent with potential synergism based on the CI and IA models, whereas other mixtures were classified as antagonistic. In addition, co-exposure significantly upregulated HPT axis-related genes (p < 0.05), suggesting potential perturbation of thyroid-related molecular pathways. Co-exposure to EHS + HMS and EHS + UV-329 showed synergistic effects on tg, but additive effects on tpo and nis, whereas HMS + UV-329 and the ternary mixture produced synergistic effects on all three genes. The ternary mixture significantly upregulated dio3, trhrα, tshr, and thrα (p < 0.05), and these responses were classified as synergistic at the tested environmentally relevant concentration. Overall, co-exposure to environmentally relevant concentrations of OUVs was associated with greater developmental and molecular-level responses in benthic fish embryos than did exposure to individual OUVs. These findings provide useful information for assessing the mixture toxicity of OUVs in estuarine environments, particularly with respect to early developmental effects in fish. - Source: PubMed
Publication date: 2026/06/11
Zhang YiningRen JinzhiShe LuhangSun ChenyangGuan ZiqiangXia SiminLi JianjunLiu JiningPeng Ying - Subclinical hypothyroidism (SH) in childhood is frequently idiopathic and usually follows a benign course. Heterozygous loss-of-function variants in the thyrotropin receptor (TSHR) gene have emerged as a genetic cause of isolated hyperthyrotropinemia; however, data regarding long-term outcomes and management are limited. - Source: PubMed
Publication date: 2026/06/05
Yaşar AyşeYarar Murat HakkıKırmızıbekmez HevesDursun Fatma - Anaplastic thyroid cancer (ATC) patient develops resistance to radioactive iodine (RAI) due to diminished sodium-iodide symporter (NIS) expression and mislocalization to the cell membrane. MAPK pathway inhibitors have demonstrated efficacy in enhancing RAI avidity in radioiodine-refractory papillary thyroid carcinoma and ATC. Elucidating this mechanism may lead to novel therapeutic approaches for ATC treatment. The cytotoxic effects of three MAPK pathway inhibitors (selumetinib, vemurafenib, dabrafenib) were assessed in ATC cell lines and xenograft models via viability assays and F-FDG PET/CT. We investigated their impact on radioiodine metabolism by analyzing the expression of key genes (NIS, TSHR, and TPO) and trafficking regulators (ARF4, PIGU, and β-catenin) via Western blotting, and assessing NIS localization and function through immunofluorescence and uptake assays. The protein interaction between NIS and ARF4 was examined via co-immunoprecipitation (co-IP) and immunofluorescence. MAPK pathway inhibitors reduced the viability of ATC cell lines. ATC cells exhibited restored iodine metabolism-related gene expression after treatment, and pronounced increases in membrane-localized NIS were detected via the promotion of ARF4 expression. Furthermore, MAPK pathway inhibitors increased radioiodine uptake in ATC cells. The MAPK pathway inhibitors enhance NIS function through two mechanisms: upregulation of NIS expression and increased ARF4-mediated NIS membrane transport. - Source: PubMed
Publication date: 2026/06/04
Wang JunfangZeng ZhenzhenXu ShashaWang XiaoxianWu KeliuChang YongguangWang GuanzhengLiu BaopingWang RuihuaHan Xingmin - Diethylene glycol dibenzoate (DEGDB), an emerging eco-friendly plasticizer, remains critically understudied with mechanistic and molecular-level evidence linking it to clear cell renal cell carcinoma (ccRCC) progression, representing a major knowledge gap. To fill this gap, we conducted a cross-scale investigation using network toxicology, WGCNA, machine learning, SHAP explainable modeling, and molecular docking as methodological tools to elucidate DEGDB‑induced ccRCC progression. By jointly mining the ChEMBL, PubChem, SwissADME, STRING, and GEO repositories, we rigorously distilled a high-confidence set of 42 target genes, among which TSHR, ADORA2B, ANPEP, CA9, CYP3A4, JUN, NR1I3, and PHGDH were highlighted. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses revealed that DEGDB may propel ccRCC progression by disrupting neuro-endocrine-immune network regulation, activating chemical carcinogenesis-related receptors, and perturbing metabolic-degradation pathways such as nitrogen metabolism and lysosomal signaling. Subsequently, 113 machine-learning algorithms were leveraged to construct predictive models, and SHAP-based interpretation pinpointed five core genes-CA9, NR1I3, PHGDH, GABRA2, and ANPEP. Validation against The Cancer Genome Atlas (TCGA) datasets demonstrated that CA9 exhibits marked expression divergence in ccRCC (box-plot analysis) and is strongly associated with unfavorable prognosis (Kaplan-Meier survival curves). Molecular-docking simulations further confirmed robust binding affinities between DEGDB and all five core target proteins (binding energies < -5 kcal/mol). In vitro assays additionally revealed that DEGDB significantly promotes 786-O and A498 proliferation and up-regulates CA9 protein expression. Collectively, our findings indicate that DEGDB accelerates ccRCC progression via the orchestrated modulation of cellular proliferation, disruption of neuro-endocrine-immune homeostasis, and activation of oncogenic receptors. This study provides a theoretical framework for assessing the environmentally relevant health risks posed by emerging plasticizers and for devising preventive strategies against DEGDB‑induced ccRCC under real‑world exposure scenarios. - Source: PubMed
Publication date: 2026/05/22
Yanping MaGuolin TianTao YangAngyang DuJiaxin LiBo TaoYajie LiYaodong JiaYuelong FengHao YangLihong NieRuining Zhao