Ask about this productRelated genes to: UCHL1 Blocking Peptide
- Gene:
- UCHL1 NIH gene
- Name:
- ubiquitin C-terminal hydrolase L1
- Previous symbol:
- PARK5
- Synonyms:
- PGP9.5, Uch-L1
- Chromosome:
- 4p13
- Locus Type:
- gene with protein product
- Date approved:
- 1991-07-15
- Date modifiied:
- 2015-11-13
Related products to: UCHL1 Blocking Peptide
Related articles to: UCHL1 Blocking Peptide
- Diabetic retinopathy (DR) is characterized by progressive retinal microvascular injury, with oxidative stress and ferroptosis increasingly recognized as key pathogenic contributors. This study investigated whether ubiquitin C-terminal hydrolase L1 (UCHL1) regulates retinal endothelial ferroptosis through stabilization of nuclear factor erythroid 2-related factor 2 (NRF2). Analysis of the GSE102485 dataset identified UCHL1 as a downregulated deubiquitinating enzyme in DR. Streptozotocin-induced type 1 diabetic mice and high glucose (HG)-induced human retinal capillary endothelial cells (HRCECs) were used, together with UCHL1 inhibition/knockdown, AAV-mediated UCHL1 overexpression, and NRF2 knockdown. UCHL1 expression was reduced in diabetic retinas and HG-induced HRCECs, accompanied by ferroptosis activation, mitochondrial injury, and endothelial dysfunction. Pharmacological inhibition or siRNA-mediated depletion of UCHL1 intensified oxidative stress, Fe⁺ accumulation, lipid peroxidation, mitochondrial fragmentation, and cristae disruption, while impairing endothelial barrier integrity, migration, and tube formation. In vivo, LDN57444 aggravated retinal vascular leakage and fundus vascular abnormalities, whereas AAV-UCHL1 preserved retinal architecture and reduced vascular permeability. Mechanistically, co-immunoprecipitation and ubiquitination assays demonstrated that UCHL1 interacted with NRF2 and stabilized NRF2 by removing K48-linked polyubiquitin chains. Nuclear-cytoplasmic fractionation further showed that UCHL1 overexpression restored NRF2 abundance and increased nuclear NRF2 accumulation under HG conditions. Ferrostatin-1 rescued UCHL1 depletion-induced ferroptotic injury, whereas NRF2 knockdown abolished the protection conferred by UCHL1 overexpression. These findings highlight the UCHL1/NRF2 axis may represent a therapeutic target in DR. - Source: PubMed
Publication date: 2026/08/21
Xu SanhuaHuang JunWang YicangShao YiMao Xinbang - Emerging traumatic brain injury (TBI) guidelines increasingly recognize the role of blood-based biomarkers in improving diagnostic and triage accuracy, yet their integration into pediatric care remains limited and underexplored. This study examined the performance of a blood-based biomarker panel in predicting which pediatric patients with TBI received neurosurgical intervention (NSI). - Source: PubMed
Publication date: 2026/08/21
Reisner AndrewAlawieh Ali MLepard Jacob RBaer Anna VZohdy Youssef MChern Joshua JMondello StefaniaJohnson Laura MWestbrook Adrianna LWang Kevin KKobeissy FirasMannix RebekahManley Geoffrey TBlackwell Laura S - Concussions in soccer are a key challenge for neurological health due to their high incidence, diagnostic complexity, and risk of long-term sequelae. This article provides a narrative review of their definition, epidemiology, pathophysiology, diagnosis, management, and prevention, integrating the most recent international guidelines. A search was conducted in Medline and Scopus (2013-2025) using terms related to "sports concussion", "traumatic brain injury," and "soccer"; 48 studies were selected. The 6th International Conference on Concussion in Sport and the criteria of the American Congress of Rehabilitation Medicine provide complementary frameworks for defining mild traumatic brain injury, based mainly on observational evidence and expert consensus. In soccer, concussions are mainly caused by head-to-head, head-to-ball, or head-to-ground impacts, with an approximate incidence of 0.5 per 1,000 hours of play and differences in recovery depending on gender. Diagnosis remains clinical and is supported by tools such as the Sport Concussion Assessment Tool 6 (SCAT6), its pediatric version (Child SCAT6), and the Concussion Recognition Tool 6 (CRT6). Current management emphasizes immediate removal from play, an initial period of relative rest, early subthreshold physical activity, and individualized rehabilitation. Biomarkers such as ubiquitin C-terminal hydrolase-L1 (UCHL1), glial fibrillary acidic protein (GFAP), and new tools such as SCOAT6 show potential but are not yet routinely recommended. The review identifies gaps in evidence for female players, youth populations, and the effects of repetitive heading, which guide future research priorities. - Source: PubMed
Russo María JulietaSalvat FernandoAmeriso SebastiánVillani DonatoVega JorgeAllegri Ricardo FSevlever Gustavo E - The incidence of sports-related concussion (SRC) in rugby has been rising in recent years. The Head Injury Assessment (HIA) protocol, used to manage SRC, is limited by its reliance on subjective symptom reporting. Blood biomarkers such as glial fibrillary acidic protein (GFAP), ubiquitin C-terminal hydrolase L1 (UCH-L1) and S100B could serve as complementary objective tools for SRC management. - Source: PubMed
Publication date: 2026/08/14
Oris CharlotteGaulmin RémiDurif JulieGoddelière VincentPereira BrunoBouvier DamienSapin Vincent - Blood biomarkers glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCH-L1) were recently introduced into clinical practice for mild traumatic brain injury (mTBI) assessment. However, real world data demonstrating TBI biomarkers' impact on the emergency department (ED) practice is lacking. This study aimed to describe the experience of a single tertiary hospital ED that introduced TBI biomarkers GFAP and UCH-L1 measurements using Alinity i TBI test into routine mTBI assessment. - Source: PubMed
Publication date: 2026/08/14
Brüning-Wolter FelixWolff NicolaSchrader MeikeMusaelyan KseniaChandran RajHoffmann MarkusMarino Jaime AMcQuiston BethCramer Jörg