Ask about this productRelated genes to: RABGGTA Blocking Peptide
- Gene:
- RABGGTA NIH gene
- Name:
- Rab geranylgeranyltransferase subunit alpha
- Previous symbol:
- -
- Synonyms:
- PTAR3
- Chromosome:
- 14q11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1996-08-14
- Date modifiied:
- 2018-04-23
Related products to: RABGGTA Blocking Peptide
Related articles to: RABGGTA Blocking Peptide
- Host genetic factors may contribute to COVID-19 severity. To identify genetic variants influencing COVID-19 severity progression, whole-exome sequencing was performed, followed by an exome-wide association study on 191 hospitalized patients categorized into three severity groups. The analysis identified nine loci surpassing the suggestive significance threshold (p ≤ 3 × 10): rs2180196 (β = 2.09, TGM1-RABGGTA), rs2236232 (β = -1.37, PLEKHH1), rs7886938 (β = 1.66, FMO6P), rs2929047 (β = -1.16, XKR4), rs9841237 (β = 1.21, SI), rs34357454 (β = 1.92, NID2), rs1005887 (β = 1.28, DUSP18), rs2281880 (β = -1.11, SUFU), and rs73061693 (β = 1.66, TULP2). Furthermore, binomial exact test identified 218 SNPs in COVID-19-related genes with significant allele frequency differences between severity groups, including 61 novel variants. Of those 218, co-occurring SNP pairs were identified within specific severity groups, including pairs in JAK1-PIK3R2 in critical patients and eight pairs in genes IL6, SERPINE1, COL5A1, MAPK14, FREM1, C7, GLS, ATP5PO, and RPL7 in severe patients. Clinical data analysis confirmed known risk factors like older age in men and specific comorbidities and revealed distinct therapeutic and biochemical profiles across severity groups. This study confirms known genetic risks and reveals novel variants, providing a more detailed basis for understanding COVID-19 pathogenesis and for developing genetic diagnostic and prognostic biomarkers. - Source: PubMed
Repušić DorisKorolija MarinaLivun AnaSvaguša TomoBelužić RobertTomaić VjekoslavKarlić RosaVlahoviček Kristian - This study aims to explore the potential molecular mechanisms by which di (2-ethylhexyl) phthalate (DEHP) exposure induces pulmonary arterial hypertension (PAH). - Source: PubMed
Publication date: 2026/03/20
Li HuaJiang YingchunLi Jijia - Protein prenylation is crucial for the function of hundreds of proteins. Aberrant protein prenylation can be caused by the aberrant expression of prenyltransferases (PTases), which has been reported for multiple cancer entities. The reasons for aberrant PTase expression in cancer have not yet been investigated. We analyzed CpG methylation within promoter-associated CpG islands of the PTase genes , , , and via bisulfite conversion and pyrosequencing to assess its role in PTase expression and gain deeper insight into the regulation of protein prenylation in cancer. We used DNA from three benign controls (whole blood samples, peripheral blood mononuclear cells, and HEK293) and 19 human cancer cell lines from various origins to assess DNA methylation within PTase gene promoter-associated CpG islands. For a subset of these cell lines, we measured mRNA expression via qPCR and correlated it with DNA methylation. Methylation across all PTase genes ranged from 1.9 ± 0.9% to 11.4 ± 4.0% (mean methylation ± standard deviation) in benign cells, and 2.3 ± 1.0% to 16.0 ± 5.4% in cancer cells. DNA methylation and mRNA expression of correlated inversely (PCC = -0.75; = 0.005). We saw no general differences between benign and malignant cells, but observed significant differences between non-malignant controls and multiple individual cancer cell lines regarding the methylation of PTase genes. This was prominently seen in in Caki-1 cells, raising the possibility that DNA methylation is involved in the dysregulation of PTase expression in cancer. - Source: PubMed
Publication date: 2026/03/04
Jung DominikDiehl DanielHagemann AnnaBachmann Hagen Sjard - There is a substantial need for scalable CRISPR-based genetic screening methods that can be applied in mammalian tissues in vivo while enabling cell-type-specific analysis. Here we developed an adeno-associated virus (AAV)-based CRISPR screening platform, CrAAVe-seq, that incorporates a Cre-sensitive sgRNA construct for pooled screening within targeted cell populations in mouse tissues. We used this approach to screen two large sgRNA libraries, which collectively target over 5,000 genes, in mouse brains and uncovered genes essential for neuronal survival, of which we validated Rabggta and Hspa5. We highlight the reproducibility and scalability of the platform and show that it is sufficiently sensitive for screening in a restricted subset of neurons. We systematically characterize the impact of sgRNA library size, mouse cohort size, the size of the targeted cell population, viral titer, and coinfection rate on screen performance to establish general guidelines for large-scale in vivo screens. - Source: PubMed
Publication date: 2025/08/22
Ramani BiswarathanRose Indigo V LTeyssier NoamPan AndrewDanner-Bocks SpencerSanghal TanyaYadanar LinTian RuilinMa KeranPalop Jorge JKampmann Martin - Protein prenylation is an important posttranslational modification being involved in several processes such as regulation of immune response. Here, we analyzed expression of four genes from this pathway, namely FNTA, RABGGTA, RABGGTB and PGGT1B in patients with neuromyelitis optica (NMO). Using the comparative ΔCt method (normalizing target gene expression to the housekeeping gene B2M), the study demonstrated that all four genes were significantly overexpressed in NMO patients compared to controls (p < 0.0001). When patients and controls were classified into high and low gene expression subgroups based on these cut-offs, an overwhelming majority of NMO patients fell into the high expression group for all four genes, whereas most healthy controls were categorized in the low expression group. All genes had appropriate performance in separation of NMO patients from controls with AUC values ranging from 0.89 to 0.97 for FNTA and RABGGTA, respectively. Altogether, the study demonstrates dysregulation of prenyltransferase-related genes in NMO and their possible application as peripheral markers. - Source: PubMed
Publication date: 2025/07/18
Taheri MohammadFeghahati Fatemeh SadatHussen Bashdar MahmudHesami OmidAbak AtefeGhafouri-Fard Soudeh