Ask about this productRelated genes to: ZNF578 Blocking Peptide
- Gene:
- ZNF578 NIH gene
- Name:
- zinc finger protein 578
- Previous symbol:
- -
- Synonyms:
- FLJ31384
- Chromosome:
- 19q13.41
- Locus Type:
- gene with protein product
- Date approved:
- 2004-02-15
- Date modifiied:
- 2014-11-19
Related products to: ZNF578 Blocking Peptide
Related articles to: ZNF578 Blocking Peptide
- This study utilizes Mendelian randomization to investigate melanoma's epidemiological patterns and genetic variants for improved disease prevention and control. - Source: PubMed
Publication date: 2025/07/19
Li ShiZhang KaijiongZhang GuijiShi MinYin XingWang Bo - Prostate cancer is characterized by structural rearrangements, most frequently including translocations between androgen-dependent genes and members of the ETS family of transcription factor like TMPRSS2:ERG. In a recent whole genome sequencing study we identified 140 gene fusions that were unrelated to ETS genes in 11 prostate cancers. The aim of the present study was to estimate the prevalence of non-ETS gene fusions. We randomly selected 27 of these rearrangements and analyzed them by fluorescence in situ hybridization (FISH) in a tissue microarray format containing 500 prostate cancers. Using break-apart FISH probes for one fusion partner each, we found rearrangements of 13 (48%) of the 27 analyzed genes in 300-400 analyzable cancers per gene. Recurrent breakage, often accompanied by partial deletion of the genes, was found for NCKAP5, SH3BGR and TTC3 in 3 (0.8%) tumors each, as well as for ARNTL2 and ENOX1 in 2 (0.5%) cancers each. One rearranged tumor sample was observed for each of VCL, ZNF578, IMMP2L, SLC16A12, PANK1, GPHN, LRP1 and ZHX2. Balanced rearrangements, indicating possible gene fusion, were found for ZNF578, SH3BGR, LPR12 and ZHX2 in individual cancers only. The results of the present study confirm that rearrangements involving non-ETS genes occur in prostate cancer, but demonstrate that they are highly individual and typically non-recurrent. - Source: PubMed
Publication date: 2015/01/27
Kluth MartinaGalal RamiKrohn AntjeWeischenfeldt JoachimTsourlakis ChristinaPaustian LisaAhrary RaminAhmed MalikScherzai SekanderMeyer AnneSirma HüseyinKorbel JanSauter GuidoSchlomm ThorstenSimon RonaldMinner Sarah