Ask about this productRelated genes to: PTGIS Blocking Peptide
- Gene:
- PTGIS NIH gene
- Name:
- prostaglandin I2 synthase
- Previous symbol:
- -
- Synonyms:
- PGIS, CYP8A1
- Chromosome:
- 20q13.13
- Locus Type:
- gene with protein product
- Date approved:
- 1994-07-28
- Date modifiied:
- 2016-10-05
Related products to: PTGIS Blocking Peptide
Related articles to: PTGIS Blocking Peptide
- - Source: PubMed
- Lipid metabolic reprogramming is increasingly recognized as a critical feature of prostate cancer progression, but the lipid metabolism-related genes that remain continuously dysregulated from normal tissue to primary tumor and metastatic disease have not been systematically characterized, and their biological and prognostic relevance remains incompletely understood. - Source: PubMed
Publication date: 2026/05/25
Li RongnaHe HongyingSun HuiLong YiliHuang NanZhu YingbingChen HongtaoJiang GuanminChen Xiaohui - Lactylation, a metabolic-driven post-translational modification, plays a critical role in tumor microenvironment (TME) remodeling. Lactylation modifies histones and non-histone proteins to regulate gene expression and cell signaling, and recent studies have linked it to immune evasion and tumor progression in bladder cancer (BLCA). However, the prognostic value of lactylation-related genes (LRGs) and their underlying immunoregulatory mechanisms in BLCA have yet to be elucidated. This study aims to establish a lactylation-based molecular classification for BLCA and to construct a robust machine learning prognostic model, thereby clarifying the immunoregulatory role of lactylation and its clinical implications. - Source: PubMed
Publication date: 2026/04/22
Zhou XiangchengWeng LianyangSun TaizeJiang QianshiZeng FanchangXu CongjieChang ChengWang YangZhou Jiaquan - Breast cancer is the most prevalent malignancy in women, and the limited effectiveness of current treatments highlights the need for novel immune regulatory mechanisms to improve long-term survival. This study investigated the role of Vim in PGI synthesis and its impact on tumor immune regulation. Multiomics profiling revealed molecular alterations following Vim deletion, which were validated in murine breast cancer models using RT-qPCR, Western blot, ELISA, and flow cytometry, with rescue experiments involving exogenous PGI. The findings showed that Vim deletion downregulated arachidonic acid metabolism, reduced PTGIS expression, and significantly lowered PGI levels. Functional assays demonstrated that Vim deficiency enhanced T cell-mediated antitumor immunity, evidenced by an increased proportion of CD8 T cells, upregulation of cytotoxic genes (, , , and ), and activation of inflammation-related signaling pathways, as indicated by enhanced phosphorylation of ERK1/2 and p65. Both exogenous PGI supplementation and ozagrel treatment reversed these effects. In conclusion, the Vim-PGI axis is identified as a key regulator of CD8 T cell immunity in breast cancer, representing a potential therapeutic target and a critical consideration in anticoagulant management during cancer immunotherapy. - Source: PubMed
Publication date: 2026/04/28
Quan HongShao LujingLi QiDong Chunyan - Recurrent cervical internal carotid artery vasospasm (RCICAV) is a rare cause of ischemic stroke in young adults. However, its pathophysiology remains largely unknown. RCICAV is a life-threatening condition, sometimes accompanied by coronary spasmodic angina in addition to severe stroke, highlighting the need for further investigation of its etiology and therapeutic approaches. - Source: PubMed
Publication date: 2026/04/25
Akagawa HiroyukiOnda HideakiMoteki YosukeSorimachi TakatoshiSaito RyoichiNihira AtsukoHori TakahiroNakamura AkikazuTerada MakikoNagasaka TakamuraChida-Nagai AyakoAoki TomohiroKubota Yuichi