Ask about this productRelated genes to: NOTCH1 Blocking Peptide
- Gene:
- NOTCH1 NIH gene
- Name:
- notch receptor 1
- Previous symbol:
- TAN1
- Synonyms:
- -
- Chromosome:
- 9q34.3
- Locus Type:
- gene with protein product
- Date approved:
- 1992-02-13
- Date modifiied:
- 2019-04-23
Related products to: NOTCH1 Blocking Peptide
Related articles to: NOTCH1 Blocking Peptide
- Oral squamous cell carcinoma (OSCC), primarily caused by high exposure to betel quid, tobacco, and alcohol, remains a major public health burden in Taiwan. Although key mutations have been identified in OSCC, the population-specific mutational landscape and its clinical relevance remain underexplored. - Source: PubMed
Publication date: 2026/07/07
Chang Chan-ChiTsai Fang-YuWu Shang-YinWang Yang-KaoSu Yu-ChuHsiao Jenn-RenJiang Shih Sheng - Seborrheic keratosis is a common benign skin tumor that affects most individuals, particularly later in life. Despite its high prevalence, the underlying biology of seborrheic keratosis remains poorly understood. In this study, we performed whole-exome sequencing and spatial transcriptomics on a cohort of seborrheic keratosis and solar lentigo lesions to gain insight into their molecular landscape. Our results reveal a high mutational burden driven by solar UV damage, with recurrent somatic variants observed in genes such as FGFR3, NOTCH1, and TP53. Spatial transcriptomic analysis uncovered a complex tissue architecture with significant heterogeneity across lesion subtypes. Furthermore, differential gene expression analysis highlighted the dysregulation of the Wnt signaling pathway as a key feature in the pathogenesis of these lesions. Together, our findings provide insights into the molecular mechanisms driving seborrheic keratosis and solar lentigo, with implications for understanding their development and progression. - Source: PubMed
Publication date: 2026/07/07
Oey Harald MKao Yung-ChingLee Katie JZhou ChenhaoBrysland Simone AJagirdar KastureeSunnefeldt ErikHammerlindl SabrinaTom Lisa NTan Jean-MarieLambie DuncanSturm Richard ASchaider HelmutDicker TonyKhosrotehrani KiarashSoyer H PeterStark Mitchell S - Irreversible loss of neuronal cells elicited by neurotraumatic injuries or neurodegenerative disorders is particularly devastating due to the limited regenerative capacity of the central nervous system (CNS). Cell reprogramming-based therapies have emerged as promising therapeutic avenues for neuronal replenishment. However, their therapeutic potential in neural regeneration still faces formidable challenges, including risks of viral vector gene delivery, potential damage from cell transplantation, and significant glial scar (GS) formation following CNS injury. Therefore, developing an optimal approach that simultaneously replaces lost neurons and overcomes these persistent obstacles is crucial for neural regeneration and functional recovery. - Source: PubMed
Publication date: 2026/07/04
Guo JianbinLi LinLiu ZijianYuan ShihaoMa XiaoyuZhang DandanDeng PengWang JinchaoChen BoAn JingLi JunpingMa QuanruiYang Hao - The aberrant activation of the NOTCH1 signaling pathway underlies the aggressive malignancy and poor prognosis of T-cell acute lymphoblastic leukemia (T-ALL). - Source: PubMed
Publication date: 2026/07/04
Li WenjuanZhou HuiQin DongmeiLin JiazhenJia ShumanWeng JianyuXu BingZha Jie - Mesenteric ischemia frequently causes bowel necrosis even after recirculation, known as reperfusion injury, and no effective therapy has been validated for preserving the intestine. Adipose-derived mesenchymal stem cell-conditioned medium (MSC-CM), a tissue engineering and regenerative therapy, has been suggested as a feasible acute-phase treatment for organ damages. This study aimed to elucidate the therapeutic effects of MSC-CM on intestinal tissue injuries by ischemia and reperfusion. Mice were categorized into three groups that underwent either 60-min mesenteric artery occlusion (ischemia group), 60-min reperfusion following 60-min occlusion (reperfusion group), or ischemia-reperfusion with the same duration following intravenous administration of 200-µL MSC-CM by retroorbital injection (MSC-CM group). The distal ileum was harvested, and immunofluorescence staining with caspase-3 and LGR5, an intestinal stem cell-specific marker, was performed for evaluating the injury location and type of cells protected by MSC-CM. Moreover, LGR5, Notch1, Jagged 1, Hes1, DLL1, DLL3, and DLL4 mRNA expressions were measured using quantitative polymerase chain reaction. Ischemia extensively damaged the epithelial layer, and reperfusion-induced cellular apoptosis at the epithelial layer. MSC-CM administration was associated with preservation of cells at the crypt base, which were identified as intestinal stem cells using double-immunofluorescence staining. The MSC-CM group demonstrated significantly higher LGR5 expression than the reperfusion and ischemia groups. Similarly, the MSC-CM group exhibited higher Notch1 and Jag1 expressions, whereas the reperfusion group showed a higher Notch1 expression. In conclusion, MSC-CM use was associated with preservation of the intestinal stem cells at the crypt of villi and higher Notch1 and Jag1 expressions. - Source: PubMed
Publication date: 2026/07/04
Yamamoto RyoSuzuki SayuriHomma KoichiroMaeshima KatsuyaKomura YasuoSasaki Junichi