Ask about this productRelated genes to: Insr Blocking Peptide
- Gene:
- INSR NIH gene
- Name:
- insulin receptor
- Previous symbol:
- -
- Synonyms:
- CD220
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2017-07-07
Related products to: Insr Blocking Peptide
Related articles to: Insr Blocking Peptide
- Keloids are pathological scars. There is a genetic predisposition for keloids, and the molecular events associated with keloid need to be profiled. - Source: PubMed
Publication date: 2026/04/22
Sun NanaLiu BoZeng NiWen YangCai YuanXu GuangchaoLiu JieLiu Jianguo - Fermented foods are recognised as functional due to their health-promoting bioactive metabolites. Our previous study showed enhanced shelf-life with stable functional metabolites of soy yoghurt fermented with Leuconostoc mesenteroides strain SB1075. Building on these findings, we prepared a new batch of SB1075-fermented soy yoghurt for animal experiments and evaluated its antidiabetic potential using transcriptomic and metabolomic approaches. GC-MS profiling confirmed reproducible metabolite patterns in fermented soy yoghurt, with the putative presence of bioactive compounds including D-pinitol and myo-inositol. Soy yoghurt was administered orally (as lyophilised powder) at the doses of 100, 200, and 400 mg/kg body weight to streptozotocin (STZ)-induced diabetic Swiss albino mice for 5 weeks, with unfermented soymilk as a control. The 100 mg/kg dose produced the most pronounced metabolic improvement, markedly reduced fasting blood glucose (90.75 ± 8.72 vs 421.5 ± 28.94 mg/dL in diabetic controls, p ≤ 0.001), improving glucose tolerance, and restoring lipid and liver biochemical parameters. Transcriptomic analysis of the intestinal tissue revealed upregulation of genes associated with insulin signalling and glucose metabolism genes (Insr, Irs1, Gck, & Pklr) alongside downregulation of inflammatory mediators (Il6 and Tnf). Metabolomic profiling further indicated differential abundance of several putatively annotated metabolites linked to metabolic regulation and oxidative stress responses. Collectively, these findings suggest that fermentation of SB1075-fermented soy yoghurt enhances the functional metabolite profile and may contribute to improved glycaemic regulation in diabetic mice. However, further studies involving targeted validation and clinical investigations will be required to confirm these mechanistic insights and evaluate the translational potential of SB1075-fermented soy yoghurt as a functional dietary intervention for metabolic health. - Source: PubMed
Publication date: 2026/04/24
Bhattacharjee Maloyjo JoyrajSheikh YunusDas SushmitaBala AsisMukherjee Ashis KKhan Mojibur Rohman - The differential diagnosis of benign and malignant pulmonary nodules is a key problem in clinical diagnosis. Low-dose spiral CT (LDCT) is a commonly used screening method, but it has the limitations of insufficient specificity. There is an urgent need for molecular markers to assist diagnosis. - Source: PubMed
Publication date: 2026/05/08
Chen JianwenLi FeiChen JianguangLi QuanxingRen YujieLiu Ruibao - The insulin receptor (INSR) serves as a central mediator in insulin signaling pathway, critically regulating cellular growth, metabolism, and homeostasis. While extensively characterized in mammals, the genomic architecture and transcriptional regulation of the INSR in avian species remain largely unexplored. Here, we delineated the chicken INSR gene using 5'/3' rapid amplification of cDNA ends (RACE) and RT-PCR, identifying three alternative first exons (exon 1A, 1B, and 1C) and their associated promoters. Dual-luciferase reporter assays demonstrated that each promoter exhibits distinct promoter activity and differential responsiveness to insulin and dexamethasone. Quantitative RT-PCR analysis further revealed tissue-specific expression patterns of the resulting transcript isoforms, with significant differences observed between lean and fat broiler lines. MEME motif analysis revealed that INSR promoters exhibited differential motif architecture across the species examined and among the three alternative promoters of the chicken INSR gene. Our findings establish that INSR expression in chickens is regulated by three alternative promoters-a paradigm divergent from the mammalian model. This work provides fundamental insights into the evolutionary divergence of insulin signaling in birds and establishes a transcriptional framework for investigating insulin resistance mechanisms in avian species. - Source: PubMed
Publication date: 2026/05/01
Lou MingHuang JiaxinLuo HaoyuGao FanMu FangWang Ning - Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE), leading to progressive renal fibrosis and functional decline. Understanding the interplay between immune cells and stromal cells is needed to develop effective therapeutic strategies. Here, we investigated the landscape of macrophage-fibroblast interactions in human LN and validated these findings in mouse models. - Source: PubMed
Publication date: 2026/04/30
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