Ask about this productRelated genes to: TERF2IP Blocking Peptide
- Gene:
- TERF2IP NIH gene
- Name:
- TERF2 interacting protein
- Previous symbol:
- -
- Synonyms:
- RAP1
- Chromosome:
- 16q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 2002-09-18
- Date modifiied:
- 2019-04-23
Related products to: TERF2IP Blocking Peptide
Related articles to: TERF2IP Blocking Peptide
- - Source: PubMed
Publication date: 2026/04/09
Sustek SamanthaMessick Troy EDheekollu JayarajuAlbitz ColtinChen ChristopherFaustino AnnelieseTang Hsin-YaoKim Hee JongMurakami KenjiLieberman Paul M - Epstein-Barr Nuclear Antigen 1 (EBNA1) is essential for the episomal maintenance and DNA replication of Epstein-Barr virus (EBV) in latently infected cells and acts through binding to . The minimal replicative unit of (½DS) contains four EBNA1 binding sites flanked by single telomeric nonamers that recruit shelterin proteins TRF2 and Rap1, but the structural basis for host-factor engagement is not known. Here, we integrate cryo-electron microscopy, zero-length cross-linking mass spectrometry, Alphafold3 modeling, and biochemical binding assays to define the complex formed by EBNA1-TRF2-Rap1 assembly on the ½DS. We find that a highly dynamic complex is formed, with the TRF2 homodimerization domain (TRFH) flexibly interacting with EBNA1 on the surface opposite the DNA-binding region, where there is a large acidic patch in EBNA1 that is unique amongst the herpesvirus episome maintenance proteins. Mutagenesis of this acidic patch abolishes TRFH binding and -dependent plasmid replication. These findings identify a previously uncharacterized acidic patch docking surface on EBNA1 essential for coordinating TRF2-RAP1 at and provide new insights into both EBV and telomere DNA replication. - Source: PubMed
Publication date: 2025/10/29
Lieberman PaulSustek SamanthaMessick TroyDheekollu JayarajuAlbitz ColtinChen ChristopherFaustino AnnelieseTang Hsin-YaoKim Hee JongMurakami Kenji - Necrosis by sodium overload (NECSO), a necrotic pathway triggered by sodium overload, has been implicated in various cellular processes. Its link to lung adenocarcinoma (LUAD) remained unexplored; this study investigated the potential relationship between NECSO and LUAD. - Source: PubMed
Publication date: 2025/10/28
Yuan JianxuZhou DalinYu Shengjie - Approximately 5-10% of cutaneous melanoma occurs in individuals with a family history of the disease. While known high-penetrance genes, such as CDKN2A, explain some cases, a substantial proportion of hereditary melanoma remains genetically undefined. Recently, germline variants in genes involved in telomere regulation, including POT1, TERT, ACD, and TERF2IP, have been identified in melanoma-prone families. This study investigated the prevalence and pathogenicity of POT1 variants in a Swedish familial melanoma cohort. Patient/material and methods: A total of 168 familial melanoma cases were screened for CDKN2A, CDK4, BAP1, and POT1. The population frequency of pathogenic variants (PVs) was assessed using the SweGen and the gnomAD databases. Functional evaluation was performed using a saturation genome editing (SGE) assay. Telomere length analysis was performed using quantitative polymerase chain reaction (qPCR) on blood-derived DNA from melanoma patients and healthy controls. The melanomas of the carriers were reviewed by expert dermatopathologists. - Source: PubMed
Publication date: 2025/08/25
Papadakis KonstantinosPortelli FrancescaSchultz KarinaOlsson Sterky HedvigVassilaki IsminiLapins JanSargen Michael RObolenski SofiaAdams David JYang MuyiHöiom VeronicaHelgadottir Hildur - Anxiety is one of the most common mental disorders. We aim to find novel biomarkers to explore its potential mechanism in anxiety disorders. Differentially expressed genes (DEGs) were screened out from GSE29014 and GSE100084 datasets. Protein-protein interaction network, enrichment analysis, and principal component analysis were employed to determine hub genes. The anxiety model was constructed by restraint stress. Behavioral tests, enzyme-linked immunosorbent assay, hematoxylin-eosin, and Nissl staining were applied to evaluate the anxiety model. The potential mechanisms were investigated by corticosterone (CORT)-induced PC12 cells as an in vitro model. Proteins and mRNA expression levels were measured by western blot and real-time quantitative polymerase chain reaction. Cell counting kit, 5-Ethynyl-2'-deoxyuridine, and flow cytometry assays were employed to measure proliferation and apoptosis. PTPRC, SMC3, STAG2, FLT3, SYNE1, TERF2IP, NIPBL, ZFP451, MLLT3, and JAK1 were identified as hub genes with high prediction value for anxiety. Hippocampal neurons were damaged with decreased 5-hydroxytryptamine, γ-amino butyric acid, and neuropeptide Y, as well as increased corticotrophin releasing factor and cholecystokinin in anxiety model. PTPRC, SMC3, STAG2, SYNE1, NIPBL, and ZFP451 were downregulated in anxiety mice. STAG2 was selected as the research target. In CORT-induced PC12 cells, STAG2 overexpression promoted cell proliferation, while inhibiting apoptosis and the expression of proteins in cGAS-STING pathway. STAG2 is a potential biomarker of anxiety that exerts a neuroprotective effect on CORT-induced PC12 cells via suppressing cGAS-STING pathway. - Source: PubMed
Yang FanZhai TianyiHuang Xiaojie