Ask about this productRelated genes to: C14ORF180 Blocking Peptide
- Gene:
- C14orf180 NIH gene
- Name:
- chromosome 14 open reading frame 180
- Previous symbol:
- C14orf77
- Synonyms:
- NRAC
- Chromosome:
- 14q32.33
- Locus Type:
- gene with protein product
- Date approved:
- 2007-11-21
- Date modifiied:
- 2017-07-20
Related products to: C14ORF180 Blocking Peptide
Related articles to: C14ORF180 Blocking Peptide
- Lung adenocarcinoma (LUAD) is one of the major histopathological types of non-small cell lung cancer (NSCLC), including solid, acinar, lepidic, papillary and micropapillary subtypes. Increasing evidence has shown that micropapillary LUAD is positively associated with a higher percentage of driver gene mutations, a higher incidence of metastasis and a poorer prognosis, while lepidic LUAD has a relatively better prognosis. However, the novel genetic change and its underlying mechanism in the progression of micropapillary LUAD have not been exactly determined. - Source: PubMed
Liang Yi-XianXie Yan-PingYu Huan-MingZhu Wen-JuanYin Cheng-YiDong Zhao-HuiZhang Xi-Lin - Rheumatoid arthritis (RA) is a complex disease with a challenging diagnosis, especially in seronegative patients. The aim of this study is to investigate whether the methylation sites associated with the overall immune response in RA can assist in clinical diagnosis, using targeted methylation sequencing technology on peripheral venous blood samples. - Source: PubMed
Publication date: 2024/03/19
Zhao JiananXu LingxiaWei KaiJiang PingChang CenXu LinshuaiShi YimingZheng YixinShan YuZheng YuejuanShen YiLiu JiaGuo ShichengWang RongshengHe Dongyi - The past decade has witnessed unprecedented scientific breakthroughs, including immunotherapy, which has great potential in clinical applications for liver cancer. - Source: PubMed
Publication date: 2023/02/13
Chen JunhongJin HengweiZhou HaoHei XufeiLiu Kai - Hypertrophic white adipose tissue (WAT) morphology is associated with insulin resistance and type 2 diabetes. The mechanisms governing hyperplastic versus hypertrophic WAT expansion are poorly understood. We assessed if epigenetic modifications in adipocytes are associated with hypertrophic adipose morphology. A subset of genes with differentially methylated CpG-sites (DMS) in the promoters was taken forward for functional evaluation. - Source: PubMed
Publication date: 2019/04/17
Kerr A GSinha IDadvar SArner PDahlman I - Obesity increases the risk of multiple diseases, such as type 2 diabetes and coronary heart diseases, and therefore the current obesity epidemic poses a major public health issue. Therapeutic approaches are urgently needed to treat obesity as well as its complications. Plasma-membrane proteins with restricted tissue distributions are attractive drug targets, because of their accessibility to various drug delivery mechanisms and potentially alleviated side effects. To identify genes involved in metabolism, we performed RNA-Seq on fat in mice treated with a high-fat diet or fasting. Here we show that the gene A530016L24Rik (human ortholog C14orf180), named Nrac, is a novel nutritionally-regulated adipose and cardiac-enriched gene. Nrac is expressed specifically and abundantly in fat and the heart. Both fasting and obesity reduced Nrac expression in white adipose tissue, and fasting reduced its expression in brown fat. Nrac is localized to the plasma membrane, and highly induced during adipocyte differentiation. Nrac is therefore a novel adipocyte marker and has potential functions in metabolism. - Source: PubMed
Publication date: 2012/09/27
Zhang RenYao FayiGao FengAbou-Samra Abdul B