Ask about this productRelated genes to: OLFML2A Blocking Peptide
- Gene:
- OLFML2A NIH gene
- Name:
- olfactomedin like 2A
- Previous symbol:
- -
- Synonyms:
- FLJ00237
- Chromosome:
- 9q33.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-04-29
- Date modifiied:
- 2019-02-26
Related products to: OLFML2A Blocking Peptide
Related articles to: OLFML2A Blocking Peptide
- Esophageal cancer (EC) is a highly aggressive malignancy associated with high rates of recurrence and metastasis, and the five-year survival rate remains only 20-30%. N6-methyladenosine (m6A), the most abundant mRNA modification, plays a pivotal role in regulating gene expression and disease pathogenesis. As an m6A "reader," heterogeneous nuclear ribonucleoprotein C (HNRNPC) binds RNA through its recognition motif and has been shown to contribute to the progression of several cancers, including colorectal, breast, and non-small cell lung cancer. However, its function and mechanism in EC remain unclear. In this study, we demonstrated that HNRNPC was upregulated in EC and correlated with poor prognosis, based on analyses of public databases and a clinical cohort. Using the xenograft mouse model, we found that HNRNPC knockdown suppressed EC tumor growth in vivo. Interestingly, mechanistic studies revealed that HNRNPC depletion promoted cell apoptosis without affecting proliferation, thereby inhibiting tumor growth. At the molecular level, HNRNPC deficiency selectively influenced transcripts with complex structures, such as CD44, OLFML2A, and PCSK6, and subsequently disrupted extracellular matrix-receptor interactions, leading to impeded tumor progression. - Source: PubMed
Publication date: 2026/04/17
Ding GangfengHe JiayaoChen YichaoLiu LeiHe QiaqiaLi Lili - Triple-negative breast cancer (TNBC) is recognized as one of the most aggressive and prognostically adverse subtypes of breast cancer. The lack of effective therapeutic targets presents substantial challenges, including impediments in early diagnosis, restricted treatment options, and a pronounced tendency for drug resistance. Despite recent advancements in the diagnosis and management of TNBC, the overall survival rate for patients remains suboptimal. Consequently, gaining a more profound understanding of its biological mechanisms and developing novel therapeutic strategies are imperative scientific priorities in this domain. - Source: PubMed
Publication date: 2026/01/13
Ding HainingChen YianYu QinghongJiang WanzhiGao Xiufei - The teat number trait in pigs has significant economic value, with Meishan and Erhualian pigs having the highest counts globally. To uncover the genetic basis of teat number variation, this study employed genome re-sequencing for a total of 1 119 individuals. Genome-wide association study (GWAS), meta-analysis, and Bayesian fine mapping were conducted. The GWAS from two breeds revealed multiple significant quantitative trait locus (QTL) for total teat number (TNT) mainly on SSC1, SSC5, SSC10, and others. Bayesian fine mapping targeted the most significant QTL in both Meishan pig GWAS and meta-analysis, mapping it to SSC1: 264 609 542 - 266 079 236 bp. Within this QTL, eighteen protein-coding genes were annotated. Bayesian fine mapping was performed for the second most significant QTL in meta-analysis, which also was the most significant QTL in Erhualian pig GWAS, identifying its mapping at SSC5: 58 228 193 - 59 198 414 bp. One protein-coding gene was annotated within this QTL. After determining the anatomical location of the mammary placodes, RNA-seq results from mammary placodes of extremely high and low 26-day-old Erhualian pig embryos were integrated, and found that only OLFML2A showed significant differential expression among these nineteen candidate genes. OLFML2A was primarily enriched in the extracellular matrix and extracellular matrix organisation pathways, which may play a role in the interaction between epithelial and stromal cells in mammary placodes. In addition, the utilisation of PigGTEx data for transcriptome-wide association study revealed a significant association between the expression level of OLFML2A in the placenta and TNT in Meishan pig. The results of phenome-wide association study further validate the significant association of OLFML2A with teat number traits in lean-type commercial pigs. Molecular validation experiments confirmed that OLFML2A specifically expresses mRNA and protein in mammary placodes. Reverse transcription-quantitative PCR results further confirmed significant differences in gene expression in the mammary placodes between extremely high and low 26-day-old Erhualian pig embryos, with the high group showing significantly higher expression levels. Differential expression analysis of mammary placodes from different litters further confirmed that the differential expression of OLFML2A was not caused by the litter effect of the sows. After integrating multiple omics, we have tentatively identified the OLFML2A gene as a potential causal gene responsible for teat number variation in Meishan and Erhualian pigs. This gene could potentially influence the development of mammary placodes in Meishan and Erhualian pigs, consequently influencing the phenotype of teat number. - Source: PubMed
Publication date: 2025/05/23
Liu C XHuang R HZhou W DJiang N JLiu QMa J FLi P HZhao Q B - Acute myeloid leukemia (AML) is a hematological malignancy. The aim of this research was to develop a ferroptosis and cuproptosis related novel prognostic signature associated with AML. - Source: PubMed
Publication date: 2024/09/05
Wu MeiLi AnanZhang TingtingDing WeirongWei YujingWan CaishuiKe BoCheng HongboJin ChenghaoKong Chunfang - Cerebral ischaemia‒reperfusion (I/R) frequently causes late-onset neuronal damage. Breviscapine promotes autophagy in microvascular endothelial cells in I/R and can inhibit oxidative damage and apoptosis. However, the mediation mechanism of breviscapine on neuronal cell death is unclear. - Source: PubMed
Publication date: 2023/09/05
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