Ask about this productRelated genes to: REG3A Blocking Peptide
- Gene:
- REG3A NIH gene
- Name:
- regenerating family member 3 alpha
- Previous symbol:
- PAP
- Synonyms:
- HIP, REG-III, REG3, PBCGF, PAP1
- Chromosome:
- 2p12
- Locus Type:
- gene with protein product
- Date approved:
- 1993-09-20
- Date modifiied:
- 2015-11-18
Related products to: REG3A Blocking Peptide
Related articles to: REG3A Blocking Peptide
- Allogeneic hematopoietic cell transplantation (allo-HSCT) is an essential therapeutic modality hematological malignancies, but acute graft-versus-host disease (aGvHD) persists as a leading cause of non-relapse mortality (NRM) . Cytokine biomarkers have already been used to predict aGvHD and outcomes. However, the standard guidelines for aGvHD biomarker panels remain controversial. We retrospectively analyzed the association of a biomarker panel (suppressor of tumorigenesis 2 [ST2], regenerating islet-derived 3 α [REG3α], Elafin, and tumor necrosis factor 1 [TNFR1]) in serum with the onset of 100-day aGvHD, 12-month NRM, and overall survival (OS) in 141 hematological malignancies patients at 19 ± 5 days after allo-HSCT from January 2022 to August 2023. Multivariable analysis showed that ST2 (P < .001) were strongly correlated with aGvHD, and TNFR1 was significantly associated with 12-month NRM and OS (P < .001). The panel of ST2, REG3α, Elafin, and TNFR1 demonstrated the best performance in diagnosis of 100-day aGvHD (area under the curve [AUC] = 0.79) and in the prediction of 12-month NRM (AUC = 0.74) and OS (AUC = 0.71). The 4-biomarker panel's risk classification predicted the 12-month cumulative incidence of NRM (43% vs 11%, P < .001) and 12-month OS (51% vs 82%, P < .001) for the high-risk and low-risk groups, respectively. Our results suggest that a combination of ST2, REG3α, Elafin, and TNFR1 is an excellent biomarker predictive panel for aGvHD diagnosis and outcomes after allo-HSCT. - Source: PubMed
Hao QiLiu XinyueLi TingtingWei WeiQi TianqiZhang ShuqinFei XinhongGu JiangyingWang Jingbo - Paneth cell metaplasia (PCM) is a phenomenon in which Paneth cells, typically found in the small intestine, appear in the colonic epithelium of patients with ulcerative colitis (UC). Our study demonstrates that the PCM occurrence correlates with disease duration and active inflammation. Furthermore, we identified IL-22, an inflammation-associated cytokine, as a key regulator that promotes PCM formation in the colonic epithelium through suppression of Notch signaling and induces REG3A expression within metaplastic niches. In vitro, we show that Reg3a directly enhances cell proliferation and promotes wound healing using mouse colonic organoids. In vivo, Reg3a mice in both acute and chronic DSS-induced colitis models exhibit delayed wound healing. Additionally, studies conducted with patient-derived human colonic organoids revealed that REG3A administration stimulates cell proliferation and accelerates wound healing. Together, these findings support a protective role of PCM-associated REG3A in the colonic epithelium of patients with UC. - Source: PubMed
Publication date: 2026/03/28
Muto TomohiroIto GoKatsuda HiromuneHiraguri YuiFujii SatoruYamamoto KuraraBernardes Joana PHinrichsen FinnUchida HitoshiNemoto YasuhiroKinoshita MayumiOshina EriYamamoto KouheiHibiya ShujiNagata SayakaSchuran FenjaYui ShiroPelczar PenelopeHuber SamuelSchreiber StefanRosenstiel PhilipWatanabe MamoruOkamoto Ryuichi - Reg3A, a member of the regenerating islet-derived protein family, possesses both antibacterial and trophic effects, offering substantial benefits in the treatment of bacteria-induced wound infections. To overcome the challenges of protein drug inactivation and degradation in the hostile microenvironment of severely infected wounds, a multifunctional hydrogel dressing composed of polyvinyl alcohol (PVA), the bifunctional crosslinker TSPBA (TPA), and recombinant Reg3A protein (rReg3A) has been developed. The TPA-PVA/rReg3A hydrogel responds to infection-induced reactive oxygen species (ROS) through dynamic boronate ester bonds. Meanwhile, it releases the active rReg3A protein in a sustained manner, thereby delivering prolonged robust antibacterial and wound-healing properties. It was demonstrated that TPA-PVA/rReg3A hydrogel exhibited significant bactericidal activity against both Staphylococcus aureus (S. aureus) and methicillin-resistant Staphylococcus aureus (MRSA). In the MRSA-induced severe wound infection murine model, TPA-PVA/rReg3A hydrogel effectively promoted wound healing by clearing pathogenic bacteria, enhancing re-epithelialization, and stimulating hair follicle formation. As expected, the therapeutic effect of the TPA-PVA/rReg3A hydrogel was obviously better than that of the active rReg3A alone. In conclusion, our study provides a promising therapeutic strategy for managing severe wound infections by enhancing the bioactivity of antimicrobial proteins. - Source: PubMed
Publication date: 2026/03/27
Yu LutingLin GuanghaoLin YuxuanFang QiongYang ShujieZhang XiyueLiu JiaChen GuoguangLuo Chen - The antimicrobial peptide regenerating family member 3α (REG3α) constitutes a critical component of epithelial immunity and microbial homeostasis, but its contribution to obesity-associated intestinal dysfunction remains unclear. We hypothesized that obesity impairs REG3α-mediated epithelial defense, promoting intestinal barrier disruption and inflammation. Circulating REG3α was analyzed in 84 individuals with normal weight, obesity, and type 2 diabetes (T2D). Jejunal REG3A expression was assessed in a subgroup undergoing bariatric surgery. Additional studies were performed in rats with diet-induced obesity and after sleeve gastrectomy and in HT-29 intestinal epithelial cells exposed to inflammatory and metabolic stimuli, recombinant REG3α, and REG3A silencing. Circulating REG3α concentrations were markedly reduced (P <0.001) in obesity, independent of glycemic status, and positively associated with insulin sensitivity. Jejunal REG3A expression was decreased (P <0.05) in individuals with obesity and T2D and correlated with circulating levels. In rats with obesity, jejunal Reg3g expression was suppressed (P <0.05) and restored (P <0.05) after weight loss induced by sleeve gastrectomy. In HT-29 cells, inflammatory cytokines (IL-33, IL-18), glucose, and lipopolysaccharide induced REG3A expression (P <0.01). REG3α modulated epithelial homeostasis by suppressing NLRP3 inflammasome signaling and extracellular matrix remodeling genes (COL1A1, COL6A3, ELN, MMP9; P <0.01) and enhancing acute inflammatory mediators (IL1B, IL6; P <0.01), tight-junction proteins (CLDN1; P <0.01), mucus (MUC2; P <0.01), and anti-inflammatory markers (KLF4; P <0.01). Conversely, REG3A silencing impaired epithelial repair pathways and CLDN1 expression. Reduced REG3α in obesity and T2D is linked to alterations in epithelial integrity and low-grade inflammation, suggesting that modulation of REG3α may represent a potential strategy to reinforce gut barrier function and metabolic homeostasis. - Source: PubMed
Cadena MaríaCasado MarcosGómez-Ambrosi JavierRamírez BeatrizBecerril SaraRodríguez AmaiaValentí VictorMoncada RafaelSilva CamiloEscalada JavierFrühbeck GemaCatalán Victoria - The clinical relevance of non-HLA antibodies remains uncertain due to the lack of standardized assays. This study aimed to assess comparative reference values for non-HLA antibody profiles in a cohort of kidney transplant candidates on the deceased donor waiting list (WL group) with 0% calculated panel reactive antibodies (cPRA) and in healthy male blood donors (BD group). - Source: PubMed
Publication date: 2026/02/13
Quintiliano AAgrawal AZuccarelli MWakefield L LSchinstock C AGandhi M JBentall A J