Ask about this productRelated genes to: REG3A Blocking Peptide
- Gene:
- REG3A NIH gene
- Name:
- regenerating family member 3 alpha
- Previous symbol:
- PAP
- Synonyms:
- HIP, REG-III, REG3, PBCGF, PAP1
- Chromosome:
- 2p12
- Locus Type:
- gene with protein product
- Date approved:
- 1993-09-20
- Date modifiied:
- 2015-11-18
Related products to: REG3A Blocking Peptide
Related articles to: REG3A Blocking Peptide
- Regenerating islet-derived protein 3-alpha (REG3A), a member of the regenerating islet-derived protein (Reg) family, belongs to the C-type lectin class of antimicrobial peptides (AMPs). It has been recognized as a critical component of intestinal mucosal barrier damage and repair. In a prospective cohort (82 ulcerative colitis [UC] patients, 20 controls), UC patients were stratified by clinical partial Mayo Score (pMS) and endoscopic activity. Fecal REG3A levels were measured across distinct patient cohorts, and diagnostic performance was evaluated and compared against fecal calprotectin (FC) and a combined model using receiver operating characteristic (ROC) analysis. REG3A expression was also evaluated in intestinal biopsies via immunohistochemistry. Fecal REG3A levels increased stepwise with UC clinical severity (p < 0.001), peaking in the severe activity group. A combined model of REG3A and FC outperformed either biomarker alone in differentiating disease activity, achieving the highest area under the curves (AUCs) for distinguishing remission from mild activity and mild from moderate activity. Immunohistochemistry confirmed REG3A expression in active UC colonic tissues. Our results indicate that fecal REG3A serves as a promising biomarker for assessing disease activity in UC. Its combination with FC enhances the accuracy of predicting clinical severity in UC. - Source: PubMed
Lv XinruiQi YaxinGuo JiaBa LingWang SipuCao HailongXu Xin - Arabidopsis MVK negatively regulates sucrose-induced anthocyanin accumulation by modulating SUC1-mediated sucrose transport and gibberellin homeostasis. Anthocyanins are flavonoid pigments that function as crucial modulators of plant responses to environmental stressors by mitigating oxidative damage and facilitating cellular adaptation. Anthocyanin biosynthesis is tightly regulated by transcriptional networks that respond to developmental cues and external stimuli. In this study, we identify mevalonate kinase (MVK), a critical enzyme in the cytosolic isoprenoid biosynthesis pathway, as a repressor of sucrose-induced anthocyanin production in arabidopsis. Loss-of-function mvk-1 mutants show increased anthocyanin levels compared to wild-type (WT) plants under high-sucrose conditions. The expression of anthocyanin biosynthetic and regulatory genes, such as CHS, DFR, and MYB75/PAP1, increases in mvk-1 mutants grown in the presence of high sucrose, and mvk-1 mutants exhibit elevated sucrose accumulation through the upregulation of sucrose transporters compared to WT under high-sucrose conditions. Furthermore, reduced gibberellic acid (GA) in mvk-1 mutants resulted in stabilization of repressors of GA signaling, known as DELLA proteins, thereby facilitating sucrose-induced anthocyanin accumulation. Our findings suggest that MVK negatively regulates sucrose-induced anthocyanin biosynthesis by modulating sucrose transport and GA homeostasis in arabidopsis. - Source: PubMed
Publication date: 2026/06/15
Kang JinkuCho SuaKang KiyoonKim DaewonBae Sang-IlShin EunjiPark So-YonStacey GaryPaek Nam-ChonCho Sung-Hwan - While plasma-derived proteins have emerged as potential biomarkers for prognosis after haematopoietic stem cell transplantation (HSCT), there are insufficient data assessing if established proteins interleukin 1 receptor-like 1 (IL1RL1), chemokine ligand 9 (CXCL9) and regenerating islet-derived 3-α (REG3α) retain their utility in the mismatched unrelated donor (MMUD) setting. We assessed their prognostic ability in 53 subjects who received MMUD HSCT from 2016 to 2023 with Day 14 or Day-30 post-HSCT samples in batch using sequential enzyme-linked immunosorbent assay. Elevated Day-30 biomarker concentrations held more prognostic value than Day 14 concentrations. Day-30 CXCL9 value showed association for overall survival (OS) with a hazard ratio of 5.86 (95% confidence interval [CI] 1.21, 28.3, p = 0.03). When stratified by high or lower threshold concentrations, Day-30 concentration revealed differences in 2-year OS for IL1RL1 (p = 0.027), CXCL9 (p = 0.011) and REG3α (p = 0.044). Day-30 area under the curve (AUCt) performance for risk of death by 2 years was 0.86 (95% CI 0.71, 1) for the combination of CXCL9 and IL1RL1, which was superior to any individual biomarker value. In this pilot analysis, Day-30 biomarkers are discriminative for OS at 2 years post-HSCT and may be able to guide future pre-emptive intervention and monitoring. - Source: PubMed
Publication date: 2026/04/28
Wang TrentFerreira Anna CHossain Nasheed MFu DenggangHill Elizabeth GJimenez Jimenez Antonio MBenjamin CaraKomanduri Krishna VPaczesny Sophie - Paneth cell metaplasia (PCM) is a phenomenon in which Paneth cells, typically found in the small intestine, appear in the colonic epithelium of patients with ulcerative colitis (UC). Our study demonstrates that the PCM occurrence correlates with disease duration and active inflammation. Furthermore, we identified IL-22, an inflammation-associated cytokine, as a key regulator that promotes PCM formation in the colonic epithelium through suppression of Notch signaling and induces REG3A expression within metaplastic niches. In vitro, we show that Reg3a directly enhances cell proliferation and promotes wound healing using mouse colonic organoids. In vivo, Reg3a mice in both acute and chronic DSS-induced colitis models exhibit delayed wound healing. Additionally, studies conducted with patient-derived human colonic organoids revealed that REG3A administration stimulates cell proliferation and accelerates wound healing. Together, these findings support a protective role of PCM-associated REG3A in the colonic epithelium of patients with UC. - Source: PubMed
Publication date: 2026/03/28
Muto TomohiroIto GoKatsuda HiromuneHiraguri YuiFujii SatoruYamamoto KuraraBernardes Joana PHinrichsen FinnUchida HitoshiNemoto YasuhiroKinoshita MayumiOshina EriYamamoto KouheiHibiya ShujiNagata SayakaSchuran FenjaYui ShiroPelczar PenelopeHuber SamuelSchreiber StefanRosenstiel PhilipWatanabe MamoruOkamoto Ryuichi - Reg3A, a member of the regenerating islet-derived protein family, possesses both antibacterial and trophic effects, offering substantial benefits in the treatment of bacteria-induced wound infections. To overcome the challenges of protein drug inactivation and degradation in the hostile microenvironment of severely infected wounds, a multifunctional hydrogel dressing composed of polyvinyl alcohol (PVA), the bifunctional crosslinker TSPBA (TPA), and recombinant Reg3A protein (rReg3A) has been developed. The TPA-PVA/rReg3A hydrogel responds to infection-induced reactive oxygen species (ROS) through dynamic boronate ester bonds. Meanwhile, it releases the active rReg3A protein in a sustained manner, thereby delivering prolonged robust antibacterial and wound-healing properties. It was demonstrated that TPA-PVA/rReg3A hydrogel exhibited significant bactericidal activity against both Staphylococcus aureus (S. aureus) and methicillin-resistant Staphylococcus aureus (MRSA). In the MRSA-induced severe wound infection murine model, TPA-PVA/rReg3A hydrogel effectively promoted wound healing by clearing pathogenic bacteria, enhancing re-epithelialization, and stimulating hair follicle formation. As expected, the therapeutic effect of the TPA-PVA/rReg3A hydrogel was obviously better than that of the active rReg3A alone. In conclusion, our study provides a promising therapeutic strategy for managing severe wound infections by enhancing the bioactivity of antimicrobial proteins. - Source: PubMed
Publication date: 2026/03/27
Yu LutingLin GuanghaoLin YuxuanFang QiongYang ShujieZhang XiyueLiu JiaChen GuoguangLuo Chen