Ask about this productRelated genes to: KHDRBS2 Blocking Peptide
- Gene:
- KHDRBS2 NIH gene
- Name:
- KH RNA binding domain containing, signal transduction associated 2
- Previous symbol:
- -
- Synonyms:
- SLM1, SLM-1, MGC26664
- Chromosome:
- 6q11.1
- Locus Type:
- gene with protein product
- Date approved:
- 2002-02-28
- Date modifiied:
- 2016-05-23
Related products to: KHDRBS2 Blocking Peptide
Related articles to: KHDRBS2 Blocking Peptide
- Insect bite hypersensitivity (IBH) is a prevalent allergic skin disease in horses that significantly affects animal welfare and shows evidence of genetic predisposition. - Source: PubMed
Publication date: 2026/03/20
Błaszczak AOlczak KStefaniuk-Szmukier MTomczyk-Wrona IMusiał A DGrzegorczyk JDługosz BSzmatoła TRopka-Molik K - Transcriptome-wide association studies (TWASs) are powerful for identifying gene-trait associations by integrating gene expression and genome-wide association data, but findings may be impacted by the choice of gene expression reference. We performed TWAS of cardiovascular outcomes using multi-tissue and ancestry-matched gene expression references. We used data from the Chronic Renal Insufficiency Cohort Study for participants of African (AFR, n = 1,512) and European (EUR, n = 2,067) ancestry and three outcomes: all-cause stroke, coronary heart disease, and heart failure. We performed TWASs using EUR and AFR predicted gene expression reference panels and multi-tissue TWAS by integrating gene expression from 10 GTEx selected tissues. TWAS identified KDELR2 associated with heart failure in AFR participants using matched AFR reference panel (p = 4.7 × 10), although findings were near significant using the EUR mismatched reference panel (p = 5.6 × 10). PSMC1 was associated with coronary heart disease in TWAS of CRIC EUR using AFR reference panel, and this gene was not present in the EUR-trained gene expression model. Multi-tissue TWASs identified KHDRBS2 significantly associated with all-cause stroke in CRIC AFR participants (p = 4.0 × 10). Variants near KDELR2 have been associated with coronary artery disease, which is a main cause of heart failure, while KHDRBS2 has been associated with cardiovascular risk factors in genome-wide association studies. Our findings highlight differences in gene discovery for TWAS of cardiovascular disease applied to high-risk participants based on participant ancestry and gene expression reference panels, and gains to identify genes compared with traditional genome-wide association approaches. - Source: PubMed
Publication date: 2026/01/08
Lin Bridget MWen JiaHorimoto Andrea R V RZhou LingboHuang ShuaiDobre MirelaGo Alan SLi YunFranceschini Nora - To investigate the biological functions of KHDRBS2 and KHDRBS3 in prostate cancer (PCa) progression and their potential roles in regulating androgen receptor splice variant 7 (AR-V7) expression, a key factor in castration-resistant prostate cancer (CRPC). - Source: PubMed
Publication date: 2025/12/19
Yang XuDongLiu XiaXiao RanCao YiLin - Sex determination is a flexible process in fish, controlled by genetics or environmental factors or a combination of both depending on the species. Revealing the underlying molecular mechanisms may have important implications for research on reproductive development in vertebrates, as well as sex-ratio control and selective breeding in fish. Phenotypic sex in rainbow trout (Oncorhynchus mykiss) is primarily controlled by a XX/XY male heterogametic sex determination system. Unexpectedly in genetically XX all-female farmed populations, a small proportion of males or intersex individuals are regularly observed. Spontaneous masculinisation is a highly heritable trait, controlled by minor sex-modifier genes that remain unknown, although several Quantitative Trait Loci (QTL) were detected in previous studies. In the current work we used genome-based approaches and various statistical methods to further investigate these QTL. DNA markers that were previously identified in a French commercial population on chromosomes Omy1, Omy12 and Omy20 were validated in six different farmed trout populations. Functional candidate genes that may be involved in spontaneous masculinisation by reducing germ cell proliferation and repressing oogenesis of XX-rainbow trout in the absence of the master sex determining gene were identified. In particular, syndig1, tlx1 and hells on Omy1, as well as khdrbs2 and csmd1 on Omy20 deserve further investigation to validate their potential sex-modifier roles as well as their interaction with rearing temperature. Those findings could be used to produce all-female populations that are preferred by farmers due to a delayed maturation of females and higher susceptibility of male trout to diseases. - Source: PubMed
Publication date: 2025/05/07
Dehaullon AudreyFraslin ClémenceBestin AnastasiaPoncet CharlesGuiguen YannQuillet EdwigePhocas Florence - Quantifying and controlling the inbreeding level in livestock populations is crucial for the long-term sustainability of animal husbandry. However, the extent of inbreeding has not been fully understood in sheep populations on a global scale. - Source: PubMed
Publication date: 2025/03/07
Ma RuiLiu JiaxinMa XiaoYang Ji