Ask about this productRelated genes to: C1ORF174 Blocking Peptide
- Gene:
- C1orf174 NIH gene
- Name:
- chromosome 1 open reading frame 174
- Previous symbol:
- -
- Synonyms:
- RP13-531C17.2
- Chromosome:
- 1p36.32
- Locus Type:
- gene with protein product
- Date approved:
- 2005-07-21
- Date modifiied:
- 2017-07-11
Related products to: C1ORF174 Blocking Peptide
Related articles to: C1ORF174 Blocking Peptide
- Major depressive disorder (MDD) and cardiovascular diseases (CVD) are mutually amplifying global health burdens, yet the causal directions and immune-determined molecular substructures that link MDD to myocardial infarction (MI) and heart failure (HF) remain poorly resolved. - Source: PubMed
Publication date: 2026/01/29
Zhou ZihaoYu XiaotongningJin YaniLiu ZiyiLiang GuoqiangMa BenHou AnqiGu TongfeiXu NaSun Shuo - Colorectal cancer (CRC) is among the lethal cancers, indicating the need for the identification of novel biomarkers for the detection of patients in earlier stages. RNA and microRNA sequencing were analyzed using bioinformatics and machine learning algorithms to identify differentially expressed genes (DEGs), followed by validation in CRC patients. - Source: PubMed
Publication date: 2024/11/05
Nazari ElhamKhalili-Tanha GhazalehPourali GhazalehKhojasteh-Leylakoohi FatemehAzari HaniehDashtiahangar MohammadFiuji HamidYousefli ZahraAsadnia AlirezaMaftooh MinaAkbarzade HamedNassiri MohammadrezaHassanian Seyed MahdiFerns Gordon APeters Godefridus JGiovannetti ElisaBatra JyotsnaKhazaei MajidAvan Amir - The underlying causes of age-related hearing loss (ARHL) are not well understood, but it is clear from heritability estimates that genetics plays a role in addition to environmental factors. Genome-wide association studies (GWAS) in human populations can point to candidate genes that may be involved in ARHL, but follow-up analysis is needed to assess the role of these genes in the disease process. Some genetic variants may contribute a small amount to a disease, while other variants may have a large effect size, but the genetic architecture of ARHL is not yet well-defined. In this study, we asked if a set of 17 candidate genes highlighted by early GWAS reports of ARHL have detectable effects on hearing by knocking down expression levels of each gene in the mouse and analysing auditory function. We found two of the genes have an impact on hearing. Mutation of Dclk1 led to late-onset progressive increase in ABR thresholds and the A430005L14Rik (C1orf174) mutants showed worse recovery from noise-induced damage than controls. We did not detect any abnormal responses in the remaining 15 mutant lines either in thresholds or from our battery of suprathreshold ABR tests, and we discuss the possible reasons for this. - Source: PubMed
Publication date: 2020/01/02
Ingham Neil JRook VictoriaDi Domenico FrancescaJames ElysiaLewis Morag AGirotto GiorgiaBuniello AnnalisaSteel Karen P - The eggshell blueness is an interesting object for chicken genetic studies and blue-shelled chicken industry, especially after the discovery of the causative mutation of chicken blue eggshell. In the present study, genome wide association study (GWAS) was conducted in Chinese Dongxiang blue-shelled chicken underlying four traits of blue eggshell pigments: quantity of biliverdin (QB), quantity of protoporphyrin (QP), quantity of total pigment (QT), and color density trait (CD). A total of 139 individuals were randomly collected for GWAS. We detected two SNPs in genome-wise significance and 35 in suggestive significance, 24 out of the 37 SNP were located either within intron/exon or near 15 genes in a range of ~1.17 Mb on GGA21. For further confirmation of the identified SNP loci by GWAS, the follow-up replication studies were performed in two populations. A total of 146 individuals of the second generation derived from the former GWAS population, as well as 280 individuals from an alternative independent population were employed for genotyping by MALDI-TOF MS in a genotype-phenotype association study. Eighteen SNPs evenly distributed on the GGA21 significant region were successfully genotyped in the two populations, of which 4 and 6 SNP loci were shown significantly associated with QB, QT and QP in the two repeat populations, respectively. Further, the SNPs were narrowed down to a region of ~ 653.819 Kb on GGA21 that harbors five candidate genes: AJAP1, TNFRSF9, C1ORF174, CAMTA1, and CEP104. Shell gland of chickens laying dark and light blue eggshell was chosen for detection of mRNA expression of the five candidate genes. The results showed differential expression levels of these genes in the two groups. The specific function of these genes has not yet been defined clearly in chickens and further in-depth studies are needed to explore the new functional role in chicken eggshell blueness. - Source: PubMed
Publication date: 2019/01/23
Darwish Hesham Y ADalirsefat Seyed BenyaminDong XiangguiHua GuoyingChen JianfeiZhang YuanyuanLi JianxiongXu JianshengLi JunyingDeng XuemeiWu Changxin