Ask about this productRelated genes to: KLHL32 Blocking Peptide
- Gene:
- KLHL32 NIH gene
- Name:
- kelch like family member 32
- Previous symbol:
- BKLHD5, KIAA1900
- Synonyms:
- -
- Chromosome:
- 6q16.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-11-21
- Date modifiied:
- 2016-10-05
Related products to: KLHL32 Blocking Peptide
Related articles to: KLHL32 Blocking Peptide
- Reproduction traits constitute the primary objective of porcine genetic improvement programs, with litter size being the principal determinant of herd reproduction output. Relative to the intensively selected Large White line, as a breed derived from Large White (LW) and Beijing Black (BJB) pigs, Jishen Black (JSB) pigs exhibit markedly lower litter size, indicating substantial potential for genetic improvement. - Source: PubMed
Publication date: 2026/06/29
Chen ChangyiZhang XiaoranLi JingKe JuanSun HaoBai ChunyanSun Boxing - Reproductive traits are critical for improving productivity and profitability in the pig industry, and genome-wide association studies (GWASs) are a powerful tool in detecting genetic markers related to target traits. Genome imputation provides an effective approach to obtain a greater number of genetic markers from low-density sequencing data. China's pig industry recently introduced an imputation panel and is now seeking to determine what types of data are required to meet breeding needs. In this study, we collected and analyzed two pig sequencing datasets, including Yorkshire pig (YY), Landrace pig (LL), and Duroc pig (DD), genotyped by either an SNP chip ( = 816) or genotyping-by-targeted sequencing ( = 314), and applied an imputation strategy before validation in a third dataset ( = 2401). The aim of this study was to identify SNPs associated with reproductive traits and compare imputation results of two different types of data to evaluate whether sample size or marker density more strongly impacts imputation-enabled GWAS performance. Through a GWAS, we identified 73 significant SNPs from imputed Chip data across seven reproductive traits, 94 SNPs from imputed GBTS data across three traits, and 34 SNPs from the combined dataset across seven traits. Seven of these SNPs passed validation and were associated with number born alive, number born healthy, and gestation length. Gestation length (GL) and number born alive (NBA) are the most noteworthy traits. and are high-confidence candidate genes affecting GL and NBA, respectively. In addition to , , , , , , , , , , , , and are associated with GL. Moreover, in addition to , , , , and are associated with NBA. The results of this study indicate that sample size is of greater importance than marker density in imputation strategies and provide beneficial insights into genes affecting pigs' reproductive traits. - Source: PubMed
Publication date: 2026/02/12
Zhou JiekeFu YangZhang YingyingTu WeilongHuang JiLiang YaxuLi BusheZhang HejunLiu YanWang KejunWang HongyangTan Yongsong - Lactylation, a recently identified post-translational modification mediated by lactate, plays a critical role in regulating metabolic and immune processes in tumors. However, its function in neuroblastoma, particularly its association with tumor progression and immune modulation, remains unclear. - Source: PubMed
Publication date: 2026/02/05
Zhu JiangquanLuo MuyangYuan LiHe JingWang ZhuDeng QiongWang JieyanJin MeiyuLiu GuochangLiang HuiFu WenYang JiefengShu Guannan - TBX5 is a key protein regulated by the TGF-β/Smad3 pathway, which plays a significant role in colorectal cancer (CRC) development. This study aims to investigate the interplay between Gegen Qinlian Decoction (GQD), TBX5, and CRC mechanisms. - Source: PubMed
Publication date: 2026/01/14
Chen DongCai YanGao WencangPang DexiangYu Senquan - Previous studies have illuminated a significant genetic component in motor neuron disease (MND) pathogenesis, with several causative genes identified. However, a substantial proportion of MND cases remain genetically unexplained, particularly regarding the comprehensive contribution of rare, high-impact variants across the exome. - Source: PubMed
Publication date: 2026/01/09
Hu ZhenWan Jing-JinYan Qin-QinFan YuLiu Jun