RFP2 Blocking Peptide
- Known as:
- RFP2 Blocking Peptide
- Catalog number:
- 33r-2197
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- RFP2 Blocking Peptide
Related genes to: RFP2 Blocking Peptide
- Gene:
- DLEU2 NIH gene
- Name:
- deleted in lymphocytic leukemia 2
- Previous symbol:
- DLB2, BCMSUN, RFP2OS
- Synonyms:
- LEU2, TRIM13OS, NCRNA00022, LINC00022, MIR15AHG
- Chromosome:
- 13q14.2
- Locus Type:
- RNA, long non-coding
- Date approved:
- 2000-11-28
- Date modifiied:
- 2018-05-16
- Gene:
- TRIM13 NIH gene
- Name:
- tripartite motif containing 13
- Previous symbol:
- RFP2
- Synonyms:
- Leu5, RNF77, DLEU5
- Chromosome:
- 13q14.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-12-01
- Date modifiied:
- 2016-10-05
Related products to: RFP2 Blocking Peptide
Related articles to: RFP2 Blocking Peptide
- Pseudoangiomatous pleomorphic/spindle cell lipoma is a rare subtype of pleomorphic/spindle cell lipoma. Only approximately 20 such tumors have been described. Genetic information on pseudoangiomatous pleomorphic/spindle cell lipoma is restricted to a single case in which deletion of the forkhead box O1 (FOXO1) gene was found, using fluorescence in situ hybridization (FISH). - Source: PubMed
Panagopoulos IoannisGorunova LudmilaLobmaier IngvildAndersen Hege KilenBjerkehagen BodilHeim Sverre - Deletion of 13q14 is the most common cytogenetic change in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and is detected in about 50 % of patients by fluorescence in situ hybridization (FISH), which can reveal presence of del(13)(q14) and mono- or biallelic deletion status without information about the size of the lost region. Array-comparative genomic hybridization (aCGH) and single nucleotide polymorphism (SNP) can detect submicroscopic copy number changes, loss of heterozygosity (LOH) and uniparental disomy (UPD) regions. The purpose of this study was detection of the size of del(13)(q14) deletion in our group of patients, comparing the size of the monoallelic and biallelic deletions, detection of LOH and UPD regions. - Source: PubMed
Publication date: 2016/01/06
Grygalewicz BeataWoroniecka RenataRygier JolantaBorkowska KlaudiaRzepecka IwonaŁukasik MartynaBudziłowska AgnieszkaRymkiewicz GrzegorzBłachnio KatarzynaNowakowska BeataBartnik MagdalenaGos MonikaPieńkowska-Grela Barbara - Although recurrent chromosomal alterations occur in chronic lymphocytic leukemia (CLL), relatively few affected tumor suppressors and oncogenes have been implicated. To improve genetic characterization of CLL, we performed high-resolution gene copy number analysis of 20 CLL patients using oligonucleotide array comparative genomic hybridization (aCGH). The most recurrent losses were observed in 13q and 11q with variable sizes. The 11q losses varied between 7.44 Mb and 41.72 Mb in size and targeted ATM among others. Lost regions in 13q were generally smaller, spanning from 0.79 Mb to 29.33 Mb. The minimal common region (158 kb) in 13q14.3, which was also homozygously deleted in some cases, harbored five genes: TRIM13, KCNRG, DLEU2, DLEU1, and FAM10A4. Additionally, two micro-RNA genes (MIRN15A and MIRN16-1) locate to the region. New cryptic losses were detected in 1q23.2-->q23.3, 3p21.31, 16pter-->p13.3, 17p13.3-->p13.2, 17q25.3-->qter, and 22q11.22. In conclusion, our oligonucleotide aCGH study revealed novel aberrations and provided detailed genomic profiles of the altered regions. - Source: PubMed
Tyybakinoja AVilpo JKnuutila S - Our group previously identified two novel genes, RFP2/LEU5 and DLEU2, within a 13q14.3 genomic region of loss seen in various malignancies. However, no specific inactivating mutations were found in these or other genes in the vicinity of the deletion, suggesting that a nonclassical tumor-suppressor mechanism may be involved. Here, we present data showing that the DLEU2 gene encodes a putative noncoding antisense RNA, with one exon directly overlapping the first exon of the RFP2/LEU5 gene in the opposite orientation. In addition, the RFP2/LEU5 transcript can be alternatively spliced to produce either several monocistronic transcripts or a putative bicistronic transcript encoding two separate open-reading frames, adding to the complexity of the locus. The finding that these gene structures are conserved in the mouse, including the putative bicistronic RFP2/LEU5 transcript as well as the antisense relationship with DLEU2, further underlines the significance of this unusual organization and suggests a biological function for DLEU2 in the regulation of RFP2/LEU5. - Source: PubMed
Corcoran Martin MHammarsund MarianneZhu ChaoyongLerner MikaelKapanadze BagratWilson BillLarsson CatharinaForsberg LarsIbbotson Rachel EEinhorn StefanOscier David GGrandér DanSangfelt Olle