Ask about this productRelated genes to: PPP4R2 Blocking Peptide
- Gene:
- PPP4R2 NIH gene
- Name:
- protein phosphatase 4 regulatory subunit 2
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 3p13
- Locus Type:
- gene with protein product
- Date approved:
- 2002-06-13
- Date modifiied:
- 2016-10-05
Related products to: PPP4R2 Blocking Peptide
Related articles to: PPP4R2 Blocking Peptide
- Chronic obstructive pulmonary disease (COPD) is associated with musculoskeletal comorbidities, including cachexia. Weight loss (WL) is the major criterion for cachexia and increases risk for mortality in COPD. Risk factors for WL in COPD are incompletely understood. We performed this whole genome sequencing (WGS) analysis to identify genetic risk variants for WL in COPD. - Source: PubMed
Chiles Joe WRocco AlisonSrinivasasainagendra VinodhRossiter Harry BCasaburi RichardThalacker-Mercer AnnaWells J MichaelWan Emily SSilverman Edwin KCho Michael HHersh Craig PPsaty Bruce MGharib Sina AGao YanO'Connor George TLange Leslie ARich Stephen SManichaikul Ani WBarr R GrahamOrtega Victor EMeyers Deborah ASmith Albert VTiwari Hemant KMcDonald Merry-Lynn N - Nucleotides-fundamental cellular building blocks-are an underappreciated dietary component, especially in aging when metabolic resilience wanes. Whether genetic background determines who benefits from NTs has been unknown. Insulin resistance (IR) underlies age-related metabolic disorders, yet responses to nutritional interventions are heterogeneous. In this secondary analysis of the TALENTs randomized controlled trial (121 adults aged 60-70 years; 19-week intervention; NCT05243108), we tested whether genetic background-quantified by a fasting-glucose polygenic risk score (FBG-PRS)-modifies the effect of exogenous nucleotides (NTs) on IR. A significant PRS × intervention interaction was observed with changes in HOMA-IR ( = 0.0115). Participants with high FBG-PRS exhibited improvements with NTs, including reduced HOMA-IR and visceral adiposity and increased limb muscle mass, whereas low FBG-PRS participants showed minimal benefit. Multi-omics supported a coherent mechanism: transcriptomics identified 39 differentially expressed genes with PPP4R2 most strongly downregulated (log 2FC = -2.00; = 2.81 × 10), and metabolomics revealed decreased cyclic AMP with enrichment of energy-metabolism pathways. These findings indicate that NTs improve insulin sensitivity primarily in genetically susceptible older adults and suggest NTs as a candidate precision-nutrition strategy for improving insulin sensitivity in aging. - Source: PubMed
Publication date: 2026/05/26
Fu RuishengWang ShuyueWu YuxiaoQin XueyingHuang TaoLi YongXu Meihong - We aimed to define the genetic architecture and regulatory mechanisms of Alzheimer's disease (AD) -related plasma biomarkers in an East Asian population. - Source: PubMed
Kim Jun PyoSong MinkuCho MinyoungLee HyunwooJung Sang-HyukLim SoohyunKim ChanheeJang BeomjinShin DaeunKang HeekyoungYim SohyunJang HyeminKim Bo-HyunKim Hee JinNa Duk LAn Joon-YongZetterberg HenrikBlennow KajGonzalez-Ortiz FernandoAshton Nicholas JDay Theresa ASeo Sang WonWon Hong-Hee - Recently, evidence has indicated that CTNNB1 is important in a variety of malignancies. However, how CTNNB1 interacts with immune cell infiltration remains to be further investigated. In this study, we focused on the correlations between CTNNB1 and tumorigenesis, tumor progression, mutation, phosphorylation, and prognosis via gene expression profiling interaction analysis; TIMER 2.0, cBioPortal, GTEx, CPTAC, and GEPIA2 database analyses; and R software. CTNNB1 mutations are most found in uterine endometrioid carcinoma and hepatocellular carcinoma. However, no CTNNB1 mutations were found to be associated with a poor prognosis. In addition, CTNNB1 DNA methylation levels were higher in normal tissues than in tumor tissues in cancer except for breast invasive carcinoma, which had higher methylation levels in tumor tissues. The phosphorylation level of the S675 and S191 sites of CTNNB1 was greater in the primary tumor tissues in the clear cell renal cell carcinoma, liver hepatocellular carcinoma, lung adenocarcinoma, pancreatic adenocarcinoma, and breast cancer datasets but not in the glioblastoma multiform dataset. As for, with respect to immune infiltration, CD8 + T-cell infiltration was negatively correlated with the expression of CTNNB1 in thymoma and uterine corpus endometrial carcinoma. The CTNNB1 level was found to be positively associated with the infiltration index of the corresponding fibroblasts in the TCGA tumors of colon adenocarcinoma, human papillomavirus-negative head and neck squamous cell carcinoma, mesothelioma, testicular germ cell tumor, and thymoma. We also identified the top CTNNB1-correlated genes in the TCGA projects and analyzed the expression correlation between CTNNB1 and selected target genes, including PPP4R2, RHOA, and SPRED1. Additionally, pathway enrichment suggested that NUMB is involved in the Wnt pathway. This study highlights the predictive role of CTNNB1 across cancers, suggesting that CTNNB1 might serve as a potential biomarker for the diagnosis and prognosis evaluation of various malignant tumors. - Source: PubMed
Xu XiaoyuanYang AiminHan YanLi SiranHao GuiminCui Na - The interactome of paraoxonase-2 encoded by the PON2 gene was investigated. A cDNA library was screened using a yeast two-hybrid system to search for new proteins interacting with human PON2. Analysis of the identified candidates, along with previously published data on interactors obtained by other methods, indicates the presence of a significant number of indirect interactions between PON2 and EGFR and, consequently, possible regulation of tumor growth with mutant EGFR involving PON2. - Source: PubMed
Publication date: 2023/01/18
Karlov V DPestov N BShakhparonov M IKorneenko T V