Ask about this productRelated genes to: SPRR3 Blocking Peptide
- Gene:
- SPRR3 NIH gene
- Name:
- small proline rich protein 3
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 1q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-01-20
- Date modifiied:
- 2016-10-05
Related products to: SPRR3 Blocking Peptide
Related articles to: SPRR3 Blocking Peptide
- - Source: PubMed
Publication date: 2026/08/12
Liao ShijunZhao WenYin ShiyuanXu JiamingYang LvyingYang YanhuiYan HuanOu TaoZeng Xiaofei - Pediatric chronic rhinosinusitis with nasal polyps (CRSwNP) exhibits a high rate of postoperative recurrence, yet effective molecular predictors remain lacking. This study aims to explore recurrence-associated proteins and evaluate their predictive value. - Source: PubMed
Publication date: 2026/06/28
Ni LiyanLi RuoqiXia SiwenWang XiaoqiongZheng BoYe YufengLiu Xuejun - This study aimed to explore the molecular alterations in airway epithelial cells in children with wheezing infected by respiratory syncytial virus (WheezeRSV). This study extracted the single-cell sequencing data of two control and wheezeRSV samples from GSE286262 dataset. The monocle2 was performed for analyzing evolution process of basal cells along disease progression. Kyoto encyclopedia of genes and genomes and gene ontology were carried out to identify the function enrichment of differentially expressed genes (DEGs) between WheezeRSV and control groups. Additionally, human nasal epithelial cells (HNECs) were harvested, and quantitative real-time polymerase chain reaction (qRT-PCR) was applied to detect the expression levels of key genes. Six cell types including ciliated cells, KRT5 + basal cells, TP63 + basal cells, KRT80 + epithelial cells, goblet cells, and club cells. The differentiation trajectory analysis on basal cells indicated two distinct branches including ciliary assembly and keratinization. Then, function analysis indicated that ciliated cells were involved in leukocyte transendothelial migration, cellular senescence and angiogenesis. Goblet cells were associated with IL-17 signaling pathway, apoptosis, and ferroptosis, and club cells were enriched in the apoptotic process and innate immune response. The qRT-PCR results revealed that the mRNA expression levels of , , , , , and were markedly upregulated in the WheezeRSV group ( < 0.01). Basal cells differentiated into keratinocytes and ciliated cells as the disease progresses, thereby enhancing defense and repairing the epithelial barrier. Meanwhile, wheezeRSV enhanced the activity of apoptosis and inflammatory response of ciliated cells, goblet cells, and club cells. - Source: PubMed
Publication date: 2026/06/24
Wei ZhengboWang LifangDing XingHaiWang ChengzhongLi Sheng - Clarification of the molecular mechanism of malignant tumor progression, identification of the key signaling pathways and molecules involved in the processes of invasion and metastasis, and identification of new targets and strategies for effective tumor treatment are extremely important for scientific research and clinical application prospects. - Source: PubMed
Publication date: 2026/04/03
Shi Yuan-Xiang - Return to sport (RTS) after anterior cruciate ligament reconstruction (ACLR) remains a critical issue in sports medicine. Despite improvements in rehabilitation, many patients fail to return to their preinjury level of activity. Previous studies have primarily focused on clinical and biomechanical factors that influence RTS; however, the impact of intrinsic physiological changes, particularly urinary proteomic profiles, has not yet been fully explored. This study aimed to identify potential urinary protein biomarkers associated with RTS in ACLR patients. - Source: PubMed
Publication date: 2026/01/10
Zhu TingLi YuanyuanZhao YingqiGong YaweiZhou JingbinXu Xin