Ask about this productRelated genes to: ZHX3 Blocking Peptide
- Gene:
- ZHX3 NIH gene
- Name:
- zinc fingers and homeoboxes 3
- Previous symbol:
- TIX1
- Synonyms:
- KIAA0395
- Chromosome:
- 20q12
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-21
- Date modifiied:
- 2014-11-18
Related products to: ZHX3 Blocking Peptide
Related articles to: ZHX3 Blocking Peptide
- Long non-coding RNAs (lncRNAs) play pivotal regulatory roles in mammalian male gametogenesis. Advances in high-throughput technologies have demonstrated that lncRNAs orchestrate robust, flexible, and context-specific gene regulatory networks through dynamic interactions with proteins, DNA, and RNA, modulating transcriptional and post-transcriptional processes. However, the mechanistic role of in situ lncRNA-mRNA interactions in spermatogonial stem cell (SSC) differentiation remains poorly understood. - Source: PubMed
Publication date: 2026/06/02
Gao WeijunXu BoMa WenzhiHe XiaojinWu Ji - Around 15-50% of patients with dMMR/MSI-H metastatic colorectal cancer (mCRC) experience primary and secondary resistance to immune checkpoint inhibitors (ICI). We previously described three transcriptomic clusters (A, B, C) linked to progression-free survival (PFS), with cluster A ("Stromal - Proliferation) associated with the shortest PFS. Here we combine gene signature and mucinous phenotype to predict the benefit from anti-CTLA-4 plus anti-PD-1. - Source: PubMed
Publication date: 2026/04/05
Ambrosini MargheritaGallois ClaireGandini AnnaliceLecanu AurélieAlouani EmilyPietrantonio FilippoBergamo FrancescaCremolini ChiaraMazard ThibaultTougeron DavidGuimbaud RosineLonardi SaraSelves JanickMouillet-Richard SophieEmile Jean-FrancoisTaieb JulienLaurent-Puig Pierre - Gastric cancer remains a leading cause of cancer-related death worldwide, underscoring the need for novel prognostic biomarkers to guide personalized therapy. Previous studies have identified that the autophagy-related gene 13 (ATG13) plays an essential role in cell biological processes, while its clinical significance and prognostic values in gastric cancer remain unclear. - Source: PubMed
Publication date: 2026/02/06
You YanjieLi WenmeiFeng YudiGao LingLi TiantianZhang XiaoliLuo Xiaomei - Lung cancer is one of the leading malignant cancers in the world with high incidence and mortality and lung adenocarcinoma (LUAD) is its major histologic subtype. Molecular biomarkers that hold prognostic value and therapeutic implication are required to evaluate disease development and enhance the survival outcomes of cancer patients. - Source: PubMed
Publication date: 2025/12/17
You YanjieLi WenmeiGao LingLi TiantianZhang XiaoliLuo Xiaomei - Previous observational studies have indicated a significant correlation between plasma proteome composition and cataract pathological status; however, the direction of causality remains uncertain. In light of the aforementioned findings, the present study employs a bidirectional two-sample Mendelian randomisation strategy, with the objective of elucidating the direct causal link between plasma proteome changes and cataract development. Following rigorous data analysis and validation, a series of plasma proteins were identified as being strongly associated with cataract risk. These included ILF3, FAM171A1, ARHGEF2, LPR1B, CRYGD, GLT8D1, ARHGEF10 and LRRTM1, all of which were confirmed to be potential risk factors for cataract. In contrast, proteins such as MXRA7, ZHX3, SPAG11B, ARID1A, DNASE1L2, COX7A1 and EEF2K were found to exert a protective effect against cataract. To gain further insight into the specific mechanisms by which these causally related proteins contribute to cataract pathology, we subsequently performed an exhaustive bioinformatics analysis. This analysis not only deepened our understanding of the functional properties of these proteins, but also revealed their possible involvement in signalling pathways and molecular interactions, thereby providing new insights into the pathogenesis of cataract. - Source: PubMed
Publication date: 2025/12/17
Han XuanWang JinyanSu XiaojuanGuo XingyuYe Hejiang