Ask about this productRelated genes to: SOX7 Blocking Peptide
- Gene:
- SOX7 NIH gene
- Name:
- SRY-box 7
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 8p23.1
- Locus Type:
- gene with protein product
- Date approved:
- 2002-02-15
- Date modifiied:
- 2016-10-05
Related products to: SOX7 Blocking Peptide
Related articles to: SOX7 Blocking Peptide
- This study aimed to delineate the molecular profile underlying progesterone resistance in atypical endometrial hyperplasia (AEH), a precancerous condition associated with a high risk of malignant transformation. Using a retrospective cohort of 20 AEH patients who completed a 6-month progestin therapy, we compared protein expression between 10 progesterone-resistant and 10 progesterone-sensitive tissues using immunohistochemistry and Western blot analysis. The results revealed a distinct molecular signature in resistant tissues, characterized by significant upregulation of estrogen signaling components (ERa, pS2, and MUC1) and proliferation markers (SOX7 and Ki-67). Concurrently, the key progesterone receptor signaling elements (PR, FKBP4, FKBP5, and FOSL2) were markedly downregulated. These findings indicate that progesterone resistance is associated with sustained activation of estrogen-driven proliferative pathways coupled with impaired progesterone signaling, leading to unabated cellular growth. The coordinated dysregulation of these hormone-responsive and proliferation-related molecules highlights a fundamental hormonal imbalance and proliferative disruption in progesterone-resistant AEH. This study provides a molecular framework for understanding progesterone resistance and suggests potential targets, such as SOX7, for future therapeutic strategies aimed at restoring hormonal sensitivity and controlling disease progression in conservative fertility-sparing management. - Source: PubMed
Huang ZhixiangJiang TingzhouYao JunTian ZhengpingLiang ZhuoLin ZhongHuang Pinxiu - Plasma concentration of high-density lipoprotein cholesterol (HDL) is among the most important risk factors for coronary artery disease and apolipoprotein A1 (APOA1) is an essential apolipoprotein that constitutes HDL. However, few comprehensive searches have been conducted to identify non-coding functional SNPs around the APOA1 gene. In this study, we report the identification of a functional SNP, rs12718466, which influences hepatocyte-specific APOA1 gene expression. Furthermore, we identified SOX7 as the transcription factor interacting with the rs12718466 SNP, using a novel screening method Transcription Factor Expression Library (TFEL) scan, which employs a comprehensive library of mouse transcription factors. SOX7 binding is allele-dependent, with stronger binding to the normal allele leading to increased APOA1 transcription. In vitro experiments in hepatocytes and in vivo experiments in mice confirmed that overexpressing SOX7 increased APOA1 expression, while knocking it down decreased both APOA1 gene expression and plasma HDL-C levels. Our research demonstrates that rs12718466 is a functional SNP that modulates APOA1 gene expression through its interaction with SOX7, thereby affecting plasma HDL-C concentrations. - Source: PubMed
Publication date: 2026/04/27
Aita YuichiTakeuchi YoshinoriMasuda YukariMehrazad Saber ZahraKarkoutly SamiaTao DuhanYe ChenMendsaikhan TsolmonSaikawa RikaKondo YasuyukiMurayama YukiShikama AkitoMatsuzaka TakashiShimano HitoshiKawakami YasushiYahagi Naoya - Wnt signaling, critical for development, is often dysregulated in cancer via genetic or/and epigenetic changes. SOX7, a high mobility group protein, is downregulated in cancers, but its alterations and underlying mechanism in gastric cancer (GsCa) pathogenesis remain to be clearly defined. - Source: PubMed
Publication date: 2026/04/21
Xie LihuaZhou JunXie JianlianChai XiaoxueLuo BingZeng XiTao QianLi Lili - Chronic obstructive pulmonary disease (COPD) and cardiovascular diseases (CVDs), including hypertension (HTN), coronary heart disease (CHD), and heart failure (HF), are major global health burdens. The shared genetic mechanisms underlying the high comorbidity between COPD and CVDs remain unclear. - Source: PubMed
Publication date: 2026/01/08
Chen ShiyuLi XiaojianXie Rongfang - This narrative review summarises glioblastoma (GBM), a very frequent invasive kind of brain tumour in the elderly that is extremely aggressive, resistant to treatment, and has a bad prognosis because of its substantial genetic and cellular heterogeneity. With a median survival of about 15 months, GBM is still an incurable cancer. This review takes full 3 months for collect all relevant knowledge about PAX and SOX gene families, which have crucial roles in the biology of GBM, as shown by recent developments in molecular pathology. Depending on certain gene expression patterns, members of these transcription factor families have been shown to have both oncogenic and tumor suppressive properties. They are important regulators of brain development, stem cell maintenance, and tumor progression. While PAX6 functions as a tumor suppressor, preventing growth and angiogenesis, PAX3, PAX5, and PAX8 are increased in GBM, encouraging proliferation, stemness, and survival. Similarly, SOX7 and SOX11 act as suppressors, and their downregulation is associated with malignancy and a bad prognosis, while SOX2, SOX3, SOX4, and SOX9 increase tumor aggressiveness and resistance to treatment. Glioma cell migration, growth, and death inhibition are further fueled through the complex interactions between canonical and non-canonical WNT signaling that modulate PAX and SOX pathways. These results highlight how crucial thorough molecular profiling is for improved categorization, prognostication, and the creation of focused treatment plans in GBM. The discovery of the dual functions of the PAX and SOX genes in GBM highlights their potential as therapeutic targets and biomarkers, opening up new possibilities for more individualised and accurate treatment approaches. - Source: PubMed
Publication date: 2026/03/03
Polley KallolFirdous Sayed Mohammed