Ask about this productRelated genes to: SOX7 Blocking Peptide
- Gene:
- SOX7 NIH gene
- Name:
- SRY-box 7
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 8p23.1
- Locus Type:
- gene with protein product
- Date approved:
- 2002-02-15
- Date modifiied:
- 2016-10-05
Related products to: SOX7 Blocking Peptide
Related articles to: SOX7 Blocking Peptide
- Timely recognition and monitoring of chronic kidney disease (CKD) is critical for improving patient outcomes. Non-coding RNAs (ncRNAs) are implicated in CKD pathophysiology. However, their clinical translation, particularly in patients on maintenance hemodialysis (MHD), and their association with erythropoiesis-stimulating agent (ESA) resistance remain under-investigated. This case-control study evaluated the signature of serum circ_DLGAP4, lncRNA KCNQ1OT1, and their targets miR-9/SOX7 in CKD across various stages, including MHD, and the clinical significance of their integration in diagnosis, staging, and ESA resistance. Overall, 180 individuals: 60 controls, 60 non-hemodialysis (non-HD) CKD G2-G4 patients, and 60 MHD patients with CKD G5, were enrolled. ncRNAs and SOX7 were measured using RT-qPCR and ELISA, respectively. Bioinformatics analysis revealed the interaction network of the investigated markers and their involvement in CKD pathophysiology. Serum circ_DLGAP4, KCNQ1OT1, and miR-9 were upregulated in CKD patients, with or without MHD, while SOX7 was downregulated in MHD patients compared to controls. circ_DLGAP4 and SOX7 were lower, and miR-9 was higher in MHD versus non-HD patients. circ_DLGAP4 and SOX7 were differentially expressed across CKD categories/stages. ROC analysis revealed diagnostic utility for circ_DLGAP4, KCNQ1OT1, and miR-9 and prognostic potential for circ_DLGAP4, miR-9, and SOX7. In multivariate analysis, KCNQ1OT1 was independently associated with CKD detection in non-HD patients. The circ_DLGAP4/SOX7 panel independently predicted CKD progression to MHD with high accuracy [Area under the curve (AUC) = 0.93, 95% confidence interval (CI) = 0.8823-0.9754]. We developed a simple nomogram for easier application in CKD progression prediction (AUC = 0.938, 95% CI = 0.8959-0.9808). circ_DLGAP4, miR-9, and SOX7 showed correlations with eGFR. miR-9 was associated with the ESA resistance index in MHD patients receiving epoetin alfa, independent of BMI. Conclusively, this study introduces serum KCNQ1OT1 as a potential candidate biomarker for CKD diagnosis, circ_DLGAP4/SOX7 as a novel panel useful for assessing CKD progression using a nomogram, and miR-9 as a potential candidate ESA resistance biomarker in MHD. Trial registration number: NCT07037953, date of registration: 10-6-2025. - Source: PubMed
Publication date: 2026/07/04
El Samaloty Nourhan MSenousy Mahmoud ASabry SarahShaker Olfat GRizk Nehal I - RNA-protein binding plays an important role in regulating protein activity by affecting localization and stability. While proteins are usually targeted via small molecules or other proteins, easy-to-design and synthesize small RNAs are a rather unexplored and promising venue. The problem is the lack of methods to generate RNA molecules that have the potential to bind to certain proteins. - Source: PubMed
Ozden FurkanBarazandeh SinaAkboga DogusTabrizi Sobhan ShokoueianSeker Urartu Ozgur SafakCicek A Ercument - Epidemiological studies have linked migraine to an increased risk of cardiovascular disease (CVD); however, the shared genetic basis and putative causal relationships between migraine subtypes and cardiovascular traits remain poorly understood. - Source: PubMed
Publication date: 2026/06/25
Liu YimingMa YouLiu Yiwei - This study aimed to delineate the molecular profile underlying progesterone resistance in atypical endometrial hyperplasia (AEH), a precancerous condition associated with a high risk of malignant transformation. Using a retrospective cohort of 20 AEH patients who completed a 6-month progestin therapy, we compared protein expression between 10 progesterone-resistant and 10 progesterone-sensitive tissues using immunohistochemistry and Western blot analysis. The results revealed a distinct molecular signature in resistant tissues, characterized by significant upregulation of estrogen signaling components (ERa, pS2, and MUC1) and proliferation markers (SOX7 and Ki-67). Concurrently, the key progesterone receptor signaling elements (PR, FKBP4, FKBP5, and FOSL2) were markedly downregulated. These findings indicate that progesterone resistance is associated with sustained activation of estrogen-driven proliferative pathways coupled with impaired progesterone signaling, leading to unabated cellular growth. The coordinated dysregulation of these hormone-responsive and proliferation-related molecules highlights a fundamental hormonal imbalance and proliferative disruption in progesterone-resistant AEH. This study provides a molecular framework for understanding progesterone resistance and suggests potential targets, such as SOX7, for future therapeutic strategies aimed at restoring hormonal sensitivity and controlling disease progression in conservative fertility-sparing management. - Source: PubMed
Huang ZhixiangJiang TingzhouYao JunTian ZhengpingLiang ZhuoLin ZhongHuang Pinxiu - Plasma concentration of high-density lipoprotein cholesterol (HDL-C) is among the most important risk factors for coronary artery disease and apolipoprotein A1 (APOA1) is an essential apolipoprotein that constitutes HDL. However, few comprehensive searches have been conducted to identify noncoding functional SNPs around the APOA1 gene. In this study, we report the identification of a functional SNP, rs12718466, which influences hepatocyte-specific APOA1 gene expression. Furthermore, we identified SRY-box transcription factor 7 (SOX7) as the transcription factor interacting with the rs12718466 SNP, using a novel screening method Transcription Factor Expression Library scan, which employs a comprehensive library of mouse transcription factors. SOX7 binding is allele-dependent, with stronger binding to the normal allele leading to increased APOA1 transcription. In vitro experiments in hepatocytes and in vivo experiments in mice confirmed that overexpressing SOX7 increased APOA1 expression, while knocking it down decreased both APOA1 gene expression and plasma HDL-C levels. Our research demonstrates that rs12718466 is a functional SNP that modulates APOA1 gene expression through its interaction with SOX7, thereby affecting plasma HDL-C concentrations. - Source: PubMed
Publication date: 2026/04/27
Aita YuichiTakeuchi YoshinoriMasuda YukariMehrazad Saber ZahraKarkoutly SamiaTao DuhanYe ChenMendsaikhan TsolmonSaikawa RikaKondo YasuyukiMurayama YukiShikama AkitoMatsuzaka TakashiShimano HitoshiKawakami YasushiYahagi Naoya