Ask about this productRelated genes to: SAMSN1 Blocking Peptide
- Gene:
- SAMSN1 NIH gene
- Name:
- SAM domain, SH3 domain and nuclear localization signals 1
- Previous symbol:
- -
- Synonyms:
- NASH1, SASH2, SH3D6B, HACS1, SLy2
- Chromosome:
- 21q11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2000-02-22
- Date modifiied:
- 2018-04-18
Related products to: SAMSN1 Blocking Peptide
Related articles to: SAMSN1 Blocking Peptide
- The psoriatic immune microenvironment (PIME) is central to psoriasis pathogenesis, yet its mechanistic drivers are incompletely defined. This study aimed to delineate immune cell infiltration patterns and identify pivotal disease-related immune genes through a systematic analysis of the PIME. - Source: PubMed
Publication date: 2026/03/19
Zheng TingjinXu RongZhang JianmingWen XiujuanHuang HaoTang HongfengZhang ZhishanZeng Chong - Alleviating hepatic lipid deposition in aging laying hens is critical for maintaining liver health and extending their productive lifespan. This study aimed to identify potential indicators and elucidate the underlying mechanisms associated with liver fat accumulation. Hepatic lipid ratio is a key indicator of the lipid deposition in the liver. A total of 509 healthy G1 line hens at 66 weeks of age were assessed for hepatic lipid ratio and stratified into three groups: low (L, <5%), medium (M, 5-10%), and high (H, >10%). The results revealed that the correlation coefficients of liver triglyceride (TG) and total cholesterol (TC) with the hepatic lipid ratio were 0.907 and 0.870, respectively, indicating a strong and highly significant association. All three metrics differed significantly among the three groups (P < 0.01), validating the grouping approach. Compared with the L group, the M and H groups showed significantly higher body weight, abdominal fat weight, abdominal fat index, plasma TG, TC, and LDL-c (P < 0.05), while plasma HDL-C was significantly lower in group H compared with groups L and M (P < 0.05). Abdominal skinfold thickness differed significantly across all groups (P < 0.05). Transcriptomic analysis revealed 115 up-regulated and 50 down-regulated genes in the H group compared with the L group. We identified: four genes (PCSK9, ABCG8, G6PC2, FOLH1) were associated with lipid metabolism; three (IL1RAPL1, TNIP2, HPSE2) with inflammatory response; five (CCL3, CCL17, CCL20, SAMSN1, ICOS) with immune response; and six (HBA1, HBAD, HBBA, CHAC1, CREG1, DDIT4) with antioxidant function. KEGG pathway analysis highlighted enrichments in lipid metabolism-related pathways such as "ABC transporters" and "Insulin secretion," as well as in the inflammatory response-related pathway "Cytokine-cytokine receptor interaction." In conclusion, body weight, abdominal skinfold thickness, plasma TG, TC, LDL-c, and HDL-c may serve as practical indicators for evaluating hepatic lipid deposition in laying hens. Excessive lipid accumulation perturbs hepatic metabolic homeostasis, triggering transcriptional reprogramming associated with both inflammatory and oxidative stress responses, alongside adaptive antioxidant defense and anti-inflammatory responses. However, further studies are required to determine whether these changes reflect a bona fide compensatory protective mechanism in the liver. - Source: PubMed
Publication date: 2026/03/13
Li YongfengWang XingguoTong HaibingQu LiangShao DanWang QiangGuo WeiGuo JunDou TaocunHu YupingLu JianMa MengFeng Chungang - NK cells are critical mediators of anti-tumor immunity whose function is frequently compromised in the tumor microenvironment. Here we identify SAM domain, SH3 domain and nuclear localization signals 1 (SAMSN1) as a previously unrecognized immune checkpoint that predominantly regulates NK cell function in hepatocellular carcinoma (HCC). Single-cell RNA sequencing (scRNA-seq) analysis reveals significant SAMSN1 upregulation in intratumoral NK cells from HCC patients, correlating with reduced granzyme B expression and poor prognosis. In orthotopic Hepa1-6 hepatocellular carcinoma models, global Samsn1 knockout (Samsn1) mice exhibits 34% tumor burden reduction with enhanced NK cell granzyme B production (P = 0.0002). Critically, NK cell-specific deletion alone (Samsn1-Ncr1) recapitulates this therapeutic effect (41% tumor burden reduction, P = 0.0017), demonstrating that SAMSN1 functions predominantly through intratumoral NK cells rather than other immune populations in the HCC microenvironment. Mechanistically, SAMSN1 suppresses NK cell activation, proliferation, and granzyme B production. These findings indicate SAMSN1 as a targetable NK cell checkpoint with direct therapeutic implications for HCC immunotherapy. - Source: PubMed
Publication date: 2026/01/21
Wang RuifengChen HuidiLiu HanyangLi QiangYao GuojingLi FulingSun PengDai TianliWang JiabeiNashan BjörnSun Cheng - Reliable molecular biomarkers for predicting cerebral infarction outcomes remain limited, highlighting the need for integrative approaches that bridge bioinformatic discovery with clinical validation. - Source: PubMed
Publication date: 2025/12/12
Fan ChangyanLi ChaoshengSui ChenyanHan LikunLiu Yong - Bullous pemphigoid (BP) is an autoimmune blistering disease driven by autoantibodies against BP180 and BP230. While type 2 inflammation plays a key role, the precise immune cell alterations and transcriptomic changes remain unclear. - Source: PubMed
Choi JeewooNam Jae-YongKim Min SungChoi You WonChoi Hae YoungByun Ji Yeon