Ask about this productRelated genes to: BMP6 Blocking Peptide
- Gene:
- BMP6 NIH gene
- Name:
- bone morphogenetic protein 6
- Previous symbol:
- VGR
- Synonyms:
- VGR1
- Chromosome:
- 6p24.3
- Locus Type:
- gene with protein product
- Date approved:
- 1991-06-05
- Date modifiied:
- 2016-10-05
Related products to: BMP6 Blocking Peptide
Related articles to: BMP6 Blocking Peptide
- Ovarian cancer (OC) is a highly aggressive malignancy with poor prognosis and limited response to immunotherapy. Ribosomal stress, a cellular response to disrupted ribosome biogenesis, has been increasingly implicated in tumorigenesis and immune regulation, yet its contribution to OC remains unclear. - Source: PubMed
Publication date: 2026/05/11
Han XuechuanYu YanFan YangZhang Miao - The Fukushima nuclear accident highlighted that evacuation-related psychosocial harm can outweigh direct radiation risks, underscoring the need to define the health impacts of chronic low-dose-rate (LDR) radiation and evidence-based thresholds for intervention. This study investigated the effects of continuous, postnatal LDR gamma irradiation (1.2 mGy/h, cumulative dose: 5 Gy) in male mice. While no changes in body weight, hippocampal neurogenesis, or major glial and neuronal populations were observed, persistent DNA damage (γ-H2AX foci) in dentate gyrus granule cells occurred in both irradiated male and female mice. Irradiated male mice developed anxiety-like behaviour, a phenotype not observed in a previously published study of female mice subjected to an identical irradiation protocol. Molecular profiling revealed two novel, dysregulated miRNA/mRNA axes in the hippocampus linking DNA damage to behaviour: a maladaptive miR-466i-5p/Tfcp2l1 pathway associated with genomic instability, and a potentially adaptive miR-101a-5p/BMP6 pathway promoting neuronal survival. Venn analysis further identified miR-124b-3p and novel-miR489-3p as conserved exposure biomarkers, altered in both the hippocampus and blood of irradiated animals. Our results show that a high cumulative dose of chronic LDR induces markedly less severe hippocampal pathology than has been reported for equivalent acute doses. These findings support the concept of dose-rate-dependent threshold dose and contribute to the evidence base for developing countermeasures following nuclear incidents or other radiation exposures. - Source: PubMed
Publication date: 2026/04/17
Tang Feng RuWang HongLau SalihahTan Amanda - Lmx1a/b paralogous genes, which arose from the invertebrate Lmx1b-like gene, are critical for hearing in multiple vertebrate species, and mutations in these genes cause hearing deficits in humans. While the unique and redundant functions of Lmx1a/b in the inner ear are well established, their contribution to the development of the cochlear nuclei, which process and relay auditory information to the brain, is poorly understood. Since cochlear nuclei maturate postnatally, here we analyzed Lmx1a;Lmx1b, Lmx1a, and Lmx1a;Lmx1b mice that survive past birth. Loss of Lmx1a reduced distinct populations of excitatory neurons in dorsal (DCN) and ventral (VCN) cochlear nuclei and their innervation from the inner ear. Additional loss of one Lmx1b copy made Lmx1a phenotypes more severe, revealing that Lmx1b acts redundantly with Lmx1a. Unlike Lmx1a mice, excitatory neurons were not affected in Lmx1a;Lmx1b mice. Thus, while cochlear nuclei are sensitive to Lmx1a/b gene dosage, these genes are not completely equivalent, and Lmx1a has a more profound role in cochlear nuclei development. Lmx1a and especially Lmx1a;Lmx1b embryos had fewer Atoh1+ progenitors that produce excitatory neurons of the cochlear nuclei, and reduced Bmp6 expression in the roof plate, the signaling center that induces these progenitors via Bmp signaling. We found that Lmx1a is the primary regulator of Bmp6, whereas Lmx1b contributes only in the absence of Lmx1a. Thus, Lmx1a plays a major role in the formation of the mature structure and connectivity of both the DCV and VCN, and Lmx1b acts redundantly to Lmx1a but only partially compensates for Lmx1a loss. - Source: PubMed
Publication date: 2026/04/17
Iskusnykh Igor YFritzsch BerndYamoah Ebenezer NSteshina Ekaterina YChizhikov Victor V - About 20-40% of prostate cancer (PCa) develop biochemical recurrence (BCR) after surgery, and propionate metabolism may contribute to tumor progression. BCR remains a major clinical challenge in PCa, as current tools based on histopathology and prostate-specific antigen (PSA) fail to capture the molecular heterogeneity driving the disease. While metabolic reprogramming is known to facilitate post-treatment adaptation, the specific role of propionate metabolism in this context remains largely unexplored. Therefore, this study aimed to systematically investigate propionate metabolism-related genes (PMRGs) to develop a novel prognostic model for the improved early prediction of recurrence. - Source: PubMed
Publication date: 2026/03/10
Lu BaosaiNiu YalinLiu XiZhao ChenmingYin Yuewei - Intervertebral disc degeneration (IVDD) is a prevalent condition causing substantial pain, muscle weakness, and functional impairment; however, the efficacy of current treatments remains limited. Therefore, candidate therapeutic targets must urgently be prioritized to guide future mechanistic and translational research. This study aims to identify genetic factors associated with IVDD and explore the underlying mechanisms through the comprehensive integration of multi-omics data. - Source: PubMed
Publication date: 2026/03/14
Kan ShunliLiu WentaoLi PeishengZhou MengmengYu HaoZheng YuwenHu WeiZhu Rusen