Ask about this productRelated genes to: PHF6 Blocking Peptide
- Gene:
- PHF6 NIH gene
- Name:
- PHD finger protein 6
- Previous symbol:
- BFLS, BORJ
- Synonyms:
- KIAA1823, MGC14797, CENP-31
- Chromosome:
- Xq26.2
- Locus Type:
- gene with protein product
- Date approved:
- 2002-02-28
- Date modifiied:
- 2019-04-23
Related products to: PHF6 Blocking Peptide
Related articles to: PHF6 Blocking Peptide
- Adult T-lymphoblastic leukemia often harbors cryptic structural variants that remain undetected by standard cytogenetic and targeted molecular testing, limiting precise risk stratification and therapeutic planning. This case is notable for the use of optical genome mapping (OGM) to uncover multiple disease-defining and likely oncogenic genomic alterations in an adult patient with newly diagnosed T-lymphoblastic leukemia. The report highlights how comprehensive structural variant profiling can refine prognosis and identify clinically meaningful aberrations that would otherwise be missed in routine practice. - Source: PubMed
Publication date: 2026/05/24
Maxfield Amanda MBickford Michelle ATonseth Kyle ABao JingMurad FarzanaWilson Devon NWainman Lauren MHill John MDonnelly Liam LKaur PrabhjotTafe Laura JKarrs Jeremiah XKhan Wahab A - Non-coding RNAs, such as circular RNAs (circRNAs), are abundant in the human body and can influence the development and progression of various diseases. However, the role they play in repairing intestinal mucosal damage remains unclear. - Source: PubMed
Publication date: 2026/05/10
Zhuang MengmengLi RanWang YiwenShan NingWang ZhiWang PeipeiWang WenshengZhang FangZhou JiayunMeng ChaoSun Yong - - Source: PubMed
Publication date: 2026/05/05
Turingan Mark AnthonyWei CuihongAlmokhtar NihadVijenthira AbiChang Hong - Plant Homeodomain Finger Protein 6 (PHF6) gene mutations are rare in acute myeloid leukemia (AML), with unclear mechanisms and uncertain prognostic value. They may compromise risk stratification and treatment decisions. This study analyzed clinical features and survival outcomes in PHF6-mutated AML patients, evaluating the impact of allogeneic hematopoietic stem cell transplantation (HSCT) and co-mutations on prognosis. Precise stratification helps optimize prognostic models and guide individualized therapy. - Source: PubMed
Wang DongmeiPan HanzhangWang YunguiXu HuanLiu LinXu YutingTong Hongyan - Analogues of a tau protein subunit (VQIVYK, or PHF6) containing a medium-sized or bulky α,β-dehydroamino acid (ΔAA) were synthesized and evaluated for their ability to inhibit aggregation of the parent peptide. The ΔAAs were constructed via the dehydration of the corresponding β-hydroxyamino acids. Some analogues were assembled by solid-phase peptide synthesis, but a solution-phase strategy was required in two cases due to the failure of a key azlactone ring-opening amidation. The ΔAA-containing peptides are 2-20 times more stable to proteolysis than related proline-containing PHF6 analogues. Transmission electron microscopy and Thioflavin T (ThT) assays revealed that the ΔAA-containing analogues are potent inhibitors of PHF6 aggregation. The impact of the analogues on the morphology of the preformed PHF6 fibrils was also investigated. This study validates the use of medium-sized or bulky ΔAAs as tools for increasing the proteolytic stability of functional peptides. - Source: PubMed
Publication date: 2026/04/28
Garcia Stephanie GAlmardini Ahmad AbdullatifPereira Aramis JXing HuihuaKnox Logan JJimenez Julie VWebster-Ford Joshua CMoyá Diego APayne Joshua CDawes Courtney KConda-Sheridan MartinCastle Steven L