Ask about this productRelated genes to: C1QTNF4 Blocking Peptide
- Gene:
- C1QTNF4 NIH gene
- Name:
- C1q and TNF related 4
- Previous symbol:
- -
- Synonyms:
- CTRP4, ZACRP4
- Chromosome:
- 11p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-10-02
- Date modifiied:
- 2017-03-01
Related products to: C1QTNF4 Blocking Peptide
Related articles to: C1QTNF4 Blocking Peptide
- The C1q/TNF-related protein (C1QTNF) plays a crucial role in the intricate connection between obesity and inflammation, acting as a significant adipokine. This study aims to investigate the potential of C1QTNF4 as an antiobesity and anti-inflammatory adipokine. - Source: PubMed
Na DaxiangHe YanweiLiu XinruiHuang MingjunXie ShuoLi HexinLiu JingyingZhang HongWang Lu - Transposable element (TE) dysregulation is associated with neuroinflammation in Alzheimer's disease (AD) brains. Yet, TE quantitative trait loci (teQTL) have not been well characterized in human aged brains with AD. - Source: PubMed
Publication date: 2024/10/02
Feng YayanYang XiaoyuHou YuanZhou YadiLeverenz James BEng CharisPieper Andrew AGoate AlisonShen YinCheng Feixiong - Frailty is the most common medical condition affecting the aging population, and its prevalence increases in the population aged 65 or more. Frailty is commonly diagnosed using the frailty index (FI) or frailty phenotype (FP) assessments. Observational studies have indicated the association of frailty with Alzheimer's disease (AD). However, the shared genetic and biological mechanism of these comorbidity has not been studied. To assess the genetic relationship between AD and frailty, we examined it at single nucleotide polymorphism (SNP), gene, and pathway levels. Overall, 16 genome-wide significant loci (15 unique loci) ( < 5 × 10) and 22 genes (21 unique genes) were identified between AD and frailty using cross-trait meta-analysis. The 8 shared loci implicated 11 genes: , , , , , , , , , , and between AD and FI, and 8 shared loci between AD and FFS implicated 11 genes: , , , , , , , , , , and . The loci 4p16.3 () was identified in both meta-analyses. The colocalization analysis supported the results of our meta-analysis in these loci. The gene-based analysis revealed 80 genes between AD and frailty, and 4 genes were initially identified in our meta-analyses: , , , and . The pathway analysis showed enrichment for lipoprotein particle plasma, amyloid fibril formation, protein kinase regulator, and tau protein binding. Overall, our results provide new insights into the genetics of AD and frailty, suggesting the existence of non-causal shared genetic mechanisms between these conditions. - Source: PubMed
Publication date: 2024/04/19
Enduru NiteshFernandes Brisa SZhao Zhongming - We investigated the correlation between serum C1q/TNF-related protein 4 (CTRP4) level and flow-mediated dilation (FMD) in patients with type 2 diabetes mellitus (T2DM), and evaluated the biological effects of CTRP4 on human umbilical vein endothelial cells (HUVECs). - Source: PubMed
Publication date: 2024/01/29
Gao JieRouzi Mai Re YanMuZhang HuihuiCai XinghuaXu BilinLu JunLei Tao - Genome-wide association studies have identified dozens of genetic risk loci for Alzheimer's disease (AD), yet the underlying causal variants and biological mechanisms remain elusive, especially for loci with complex linkage disequilibrium and regulation. - Source: PubMed
Publication date: 2023/06/07
Xu MinLiu QianjinBi RuiLi YuLi HongliKang Wei-BoYan ZhongjiangZheng QuanzhenSun ChunliYe MaosenXiang Bo-LinLuo Xiong-JianLi MingZhang Deng-FengYao Yong-Gang