Ask about this productRelated genes to: CPEB4 Blocking Peptide
- Gene:
- CPEB4 NIH gene
- Name:
- cytoplasmic polyadenylation element binding protein 4
- Previous symbol:
- -
- Synonyms:
- KIAA1673
- Chromosome:
- 5q35.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-07-22
- Date modifiied:
- 2016-10-05
Related products to: CPEB4 Blocking Peptide
Related articles to: CPEB4 Blocking Peptide
- In recent decades, genetic research in cattle has largely prioritised cosmopolitan breeds and production traits, often overlooking functional and fitness-related characteristics such as longevity, fertility, and udder health. These fitness traits, although critical for animal welfare and sustainable farming, are challenging to improve due to their low heritability and complex genetic background. This study investigates the genomic architecture of three key fitness traits: longevity (LONG), fertility (measured as days open, DO), and udder health (somatic cell score, SCS)-in two local dual-purpose breeds, Alpine Grey (AG) and Rendena (RE), using a genome-wide association study (GWAS). For AG breed, 2 745 genotyped animals were considered and 2 251 from the RE breed. For LONG, 37 053 and 9 782 phenotypic records were, in AG and RE, respectively, while 30 316 (AG) and 19 822 (RE) for DO; and 113 297 (RE) and 792 921 (AG) for both SCS and milk yield. In GWAS, pseudophenotypes were utilised to address data imbalance. A total of 744 quantitative trait loci (QTLs) associated with the three traits were identified, which were associated with 26 annotated genes explaining more than 1% of the additive genetic variance. Candidate genes significantly associated with target traits include CPEB4 (LONG in RE, SCS in both breeds), DSC2 (DO in AG, SCS in RE), LCORL (LONG and SCS in RE), PRMT8 (LONG in both breeds, MY in RE), RAPGEF6 (LONG in AG), TEAD4 (MY in RE), TSPAN9 (LONG in both), and XKR4 (DO and SCS in RE). These genes participate in vital biological functions such as spermatogenesis, mitochondrial regulation, cellular signalling, and tissue integrity, underlining their relevance in fertility, animal health, and productivity. Notably, several genes identified as significant in our study have previously been associated with both milk and beef production traits in the literature, suggesting that key functional traits related to dual-purpose performance remain detectable despite ongoing selection primarily focused on milk yield. This versatility is essential for their continued adaptability to diverse farming systems and market needs. Overall, the findings provide insights into genomic regions associated with fitness traits in local cattle breeds, emphasizing the value of integrating these traits into breeding programmes. The identification of genetic markers offers valuable opportunities to improve selection strategies that promote animal welfare and sustainable production, reinforcing the role of genetic diversity in dual-purpose local breeds within modern agriculture. - Source: PubMed
Publication date: 2026/02/20
Oian AMancin EGomez Proto GRulli ESartori CMantovani R - Unstable ion channel mRNAs contribute to electrical remodeling and arrhythmic risk in heart failure. CPEB4 promotes cytoplasmic polyadenylation and stabilizes target mRNAs, thereby supporting translation. CPEB4 expression was reduced in human heart failure and in mouse and cellular models of ischemic or hypoxic stress. Cpeb4 deficiency in mice caused QRS widening, reduced R-wave amplitude, and decreased SCN5A mRNA, Na1.5 protein, and sodium current. Restoring Cpeb4 expression after infarction preserved SCN5A/Na1.5 and sodium current. The CPEB4-SCN5A axis is a key determinant of myocardial excitability under stress, and RNA stability may be targeted therapeutically to maintain electrical integrity in ischemic cardiomyopathy. - Source: PubMed
Publication date: 2026/03/16
Kang Gyeoung-JinKim EunjiXie AnLiu HongDudley Samuel C - Autism spectrum disorder (ASD) involves impaired synaptic plasticity tightly coupled to local mRNA translation. Cytoplasmic polyadenylation element-binding proteins 3 and 4 (CPEB3 and CPEB4) are post-transcriptional regulators of neuronal mRNA translation that may contribute to ASD-related molecular alterations. In this theoretical-computational study, we develop a weighted functional impact model that integrates transcriptomic expression with intrinsic molecular constraints of CPEB3 and CPEB4 to estimate regional and cell type-specific vulnerability in ASD. Coarse-grained molecular dynamics (MD) simulations were quantitatively analyzed to assess aggregation, diffusion, and cluster stability under cell type-specific cytoplasmic conditions, with statistical uncertainty explicitly evaluated. The anterior cingulate cortex and thalamus emerged as primary vulnerability sites. Despite higher CPEB4 expression-mainly in glial cells-our weighted functional impact model predicted greater theoretical susceptibility linked to CPEB3 dysfunction, particularly in inhibitory and excitatory neurons. MD simulations revealed that CPEB3 forms transient diffusion-permissive aggregates, whereas CPEB4 tends to assemble into more stable condensates. These complementary behaviors suggest differential but interdependent regulation of neuronal and glial functions. Importantly, the proposed framework provides experimentally testable predictions on how protein-protein interactions, microexon loss, and cytoplasmic crowding influence translational control in ASD. This integrative approach provides a quantitative and biologically grounded framework to investigate how post-transcriptional regulators contribute to ASD-relevant molecular vulnerability. - Source: PubMed
Publication date: 2026/01/23
González-Paz LeninVivas AlejandroCardozo-Urdaneta ArleneLossada CarlaMendez AnibalDelgado ArianaMarrero-Ponce YovaniMartinez-Rios FelixPérez-Castillo YunierkisAlvarado Ysaías J - Neurons of distinct subtypes compartmentalize subtype-specific function in part by differentially localizing and translating specific RNAs, but underlying mechanisms are not understood. Here we investigate messenger RNA localization and stability within subtype-specific growth cones (GCs), leading tips of growing axons, of long-range projection neurons (PNs) of the developing cerebral cortex. Comparison of GC-localized transcriptomes between two subtypes of PNs (interhemispheric-callosal and corticothalamic) across developmental stages identified both distinct and shared subcellular machinery involved in distinct phases of growth, target innervation and synaptogenesis, and enrichment of genes associated with neurodevelopmental and neuropsychiatric disorders. Further, we investigated sequence elements in dynamically GC-localized mRNAs, identifying GC-enriched motifs in 3' untranslated regions. For example, we identified that CPEB4, a translational regulator, regulates axonal branching and that RBMS1 functions dynamically in callosal circuit formation. This work offers generalizable insights for subcellular specialization in other polarized cells, toward elucidating neurodevelopmental and behavioral-cognitive disorders. - Source: PubMed
Publication date: 2025/12/29
Veeraraghavan PriyaEngmann Anne KHatch John JItoh YasuhiroNguyen DuaneAddison ThomasMacklis Jeffrey D - Gliomas are complex and among the most lethal central nervous system (CNS) disorders. While they are notoriously heterogeneous, evidences suggest critical involvement of intricate interactions between RNA-binding proteins (RBPs) and their diverse partners, in the pathogeneses of gliomas. In this study, we used RNA sequencing data from the Cancer Genome Atlas (TCGA) to identify differentially expressed genes (DEGs). After selection of differentially expressed RBPs from these DEGs, systematic investigation of their transcriptomic changes during glioma progression was undertaken. Extensive in silico assessments allowed the creation of their interactome and pathway, identifying potential biological effects of these differentially expressed RBPs. Construction of regulatory networks of these differentially expressed RBPs and their topological analysis discovered key RBPs such as PABPC1, EIF4A2, RPS3, EEF1A1, RPS6, ELAVL2, CPEB1, and CELF5, which are largely involved in alternative splicing and ribosomal biogenesis. Moreover, we also identified differentially expressed RBPs such as YBX1, ELAVL2, and IGF2BP1, which may be involved in the formation of stress granules in gliomas. We also identified highly mutated RBPs, such as RPSA, RPL5, CPEB4, and SMAD7, in gliomas. Further, RBPs like RPS8, RPL5, RPS3A, EEF1A1, and EIF4E1B were found to be strongly correlated with patients' overall survival. Taken together, our analyses identified several candidate RBPs which might serve as potential targets for oncological measures against gliomas. - Source: PubMed
Publication date: 2025/12/08
Haque ShafiulMathkor Darin MansorBabegi Ashjan SaeedAhmad FarazArumugam Mohanapriya