Ask about this productRelated genes to: TAF7L Blocking Peptide
- Gene:
- TAF7L NIH gene
- Name:
- TATA-box binding protein associated factor 7 like
- Previous symbol:
- TAF2Q
- Synonyms:
- CT40
- Chromosome:
- Xq22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2000-06-29
- Date modifiied:
- 2015-11-20
Related products to: TAF7L Blocking Peptide
Related articles to: TAF7L Blocking Peptide
- Sheep () is a poly-ovulatory species, with litter size varying considerably within and among breeds. Litter size reflects ewe prolificacy, and prolific breeds represent valuable genetic resources for the sheep industry. Belclare is a composite sheep breed developed primarily for reproductive performance and used for meat production. Artificial selection for beneficial alleles related to reproductive traits can create detectable genomic patterns known as selection signatures (SS). This study aimed to detect selection signatures on autosomes and the X chromosome in Belclare sheep and annotate candidate regions associated with reproductive traits. A total of 8421 ewes genotyped with the OvineSNP50 BeadChip were analyzed. Breeds were classified into two groups: prolific (Belclare) and less prolific (Beltex, Charollais, Suffolk, and Texel). Inter-population selection signatures were detected using Cross-Population Extended Haplotype Homozygosity (XP-EHH) and Fixation Index (FST) in 100-kb non-overlapping windows across autosomes (top 1%) and the X chromosome (top 10%). Overlapping signals formed regions ranging from 200-400 kb. Using XP-EHH, regions of 400 kb were detected on OAR3 and OAR5, while one shared SS between XP-EHH and F was identified on OARX. The genes within these regions were associated with reproductive traits in both ewes and rams. X-linked genes, including , and , were associated with sperm motility. Genes involved in ovarian processes, including follicular development, ovulation, and early pregnancy, such as , and , were also identified within the SS regions. Overall, the SS detected in Belclare elucidated the genetic basis underlying its prolificacy relative to less prolific breeds. - Source: PubMed
Publication date: 2026/04/15
Lisboa Rodrigues JuliaSchramm Schenkel FlavioGraciano Braga LarissaAlmeida Rollo de Paz Ana CarolinaNakamura Watanabe RafaelMcHugh NoirinPearse Berry DonaghEli Buzanskas MarcosPrado Munari Danísio - Peripheral nervous system (PNS) neurons can regenerate after injury, yet functional recovery is often limited, especially following proximal lesions or delayed repair. Preconditioning nerve injury accelerates axonal growth by inducing regeneration associated genes (RAGs). To identify novel growth regulators, we screened nine genetically diverse Collaborative Cross (CC) mouse strains for strain-dependent differences in dorsal root ganglion (DRG) neurite outgrowth on Matrigel. All strains exhibited a ≥ 2-fold preconditioning effect, with DBA/2J showing the most pronounced growth. Genome-wide expression profiling revealed Taf7l as the transcript most strongly correlated with neurite outgrowth. Immunohistochemistry demonstrated Taf7l localization in DRG neurons, with expression enhanced after preconditioning. Quantitative RT-PCR showed a progressive post-injury increase in Taf7l mRNA, reaching > 5-fold by day 14. Functional studies using lentiviral vectors showed that Taf7l knockdown reduced neurite length by 27% without affecting initiation rate, while Taf7l overexpression significantly increased both initiation rate and axonal length. These findings identify Taf7l, previously known for roles in spermatogenesis and adipogenesis, as a novel transcriptional regulator in neurons. Taf7l is induced by nerve injury and modulates neurite outgrowth, suggesting it as a potential therapeutic target to enhance PNS regenerative capacity. - Source: PubMed
Publication date: 2026/02/21
Sugiura KaoriOmura TakaoWang JiliLatremoliere AlbanMatsuyama Yukihiro - Activin A affects placental decidualisation and trophoblast growth and invasion. Levels increase during pregnancy, peaking at parturition, while premature elevation is a hallmark of several pregnancy disorders. We examined the impact of unopposed/elevated activin A bioactivity in the inhibin α knockout (Inha KO) mouse placenta which lacks competitive inhibition by inhibin A. We also investigated whether simultaneous exposure to the endocrine disruptor, diethyl-hexyl phthalate (DEHP), which impairs normal placental function and affects activin A signalling in other organs, exacerbates morphological and transcriptional effects. - Source: PubMed
Publication date: 2025/05/20
Klompmaker LaceyMoody Sarah CMa Junlan IrisCamm Emily JMalliaras ConstanceMarshall Sarah ALoveland Kate L - X-chromosome variants contribute significantly to hypospadias risk but have not been fully elucidated in the Chinese population. Here we aim to assess how X-chromosome variants contribute to hypospadias susceptibility in the Chinese population. - Source: PubMed
Publication date: 2025/05/07
Liu YanqingLi BinyaoDeng FumingZhao XinyingLiu ZhihaiZhao JingluFu WenZhang YanZuo Xiaoyu - Head and neck cancer is the sixth most common malignancy worldwide, with the relatively low 5-year survival rate, mainly because it is diagnosed at a late stage. Infection with HPV is a well known aetiology, which affects the nature of these cancers and patients' survival. Besides, it is considered that the main driving force for this type of cancer could be epigenetics. In this study we aimed to find potential epigenetic biomarkers, by integrating miRNome, methylome, and transcriptome analyses. From the fresh head and neck cancer tissue samples, we chose a group for miRNome, methylome and transcriptome profiling, in comparison to adequate control samples. Bioinformatics analyses are performed in R v4.2.2. Count normalisation and group differential expression for mRNA and the previously obtained miRNA count data was performed with DESeq2 v1.36. Gene set enrichment analysis was performed and visualised using gProfiler2 v0.2.1 Identification of miRNA targets was performed by querying in miRTarBase using multiMiR v1.18.0. Annotation of CpG sites merging into islands was obtained from RnBeads.hg19 v1.28.0. package. For the integrative analysis we performed kmeans clustering using stats v4.2.2 package, using 8-12 clusters and nstart 100. We found that transcriptome analysis divides samples into cancers and controls clusters, with no relation to HPV status or cancer anatomical location. Differentially expressed genes (n = 2781) were predominantly associated with signalling pathways of tumour progression. We identified a cluster of genes under the control of the transcription factor E2F that are significantly underexpressed in cancer tissue, as well as T cell immunity genes and genes related to regulation of transcription. Among overexpressed genes in tumours we found those that belong to cell cycle regulation and vasculature. A small number of genes were found significantly differentially expressed in HPV-positive versus HPV-negative tumours (for example NEFH, ZFR2, TAF7L, ZNF541, and TYMS). In this comprehensive study on an overlapping set of samples where the integration of miRNome, methylome and transcriptome analysis were performed for head and neck cancer, we demonstrated that the majority of genes were associated exclusively with miRNome or methylome and, to a lesser extent, under the control of both epigenetic mechanisms. - Source: PubMed
Publication date: 2024/04/20
Mandić KatarinaMilutin Gašperov NinaBožinović KsenijaDediol EmilKrasić JureSinčić NinoGrce MagdalenaSabol IvanBarešić Anja