Ask about this productRelated genes to: SLC5A7 Blocking Peptide
- Gene:
- SLC5A7 NIH gene
- Name:
- solute carrier family 5 member 7
- Previous symbol:
- -
- Synonyms:
- hCHT, CHT1
- Chromosome:
- 2q12.3
- Locus Type:
- gene with protein product
- Date approved:
- 2000-11-27
- Date modifiied:
- 2016-10-05
Related products to: SLC5A7 Blocking Peptide
Related articles to: SLC5A7 Blocking Peptide
- Acute colitis is an inflammatory condition of the equine colon associated with high morbidity and mortality. In these horses, epithelial barrier function is critical but the mechanisms underlying large intestinal epithelial damage and recovery are incompletely understood. - Source: PubMed
Publication date: 2026/04/23
Sheahan B JO'Neill M KJeter M AMcDermott L BMegeed H S - Ammonia metabolism disruption critically causes immunosuppression in aquatic animals. This study systematically characterized the ammonia transporter (AMT) gene family and its immune regulatory mechanism in the Pacific oyster (Crassostrea gigas). Through genome-wide screening, four family members were identified, including three ammonium transporters (CgAMT1, CgAMT1-like, and CgAMT3) and one Rhesus blood group-associated A glycoprotein (CgRhAG). All identified proteins contain conserved structural motifs essential for ammonia selectivity, namely the phenylalanine gate and the twin-histidine motif. CgAMTs genes were constitutively expressed across oyster tissues, with CgAMT1 predominantly expressed in haemocytes, suggesting its involvement in immune regulation. Under stimulation with four pathogen-associated molecular patterns (PAMPs), CgAMT1 was significantly upregulated by an average of 2.8-fold. Protein interaction network analysis predicted functional associations between CgAMT1 and MLH1, SLC5A7, and RPS9, which are involved in DNA mismatch repair, ion transport, and protein synthesis, respectively. Long-term Vibrio splendidus stimulation confirmed progressive ammonia accumulation and haemocyte death, with CgAMT1 expression increasing by 7.5-fold and coordinated upregulation of MLH1, SLC5A7, and RPS9. This study identifies a potential ammonia-associated immune cell death mechanism in bivalves, providing molecular targets for aquaculture disease control. - Source: PubMed
Publication date: 2026/03/18
Sun PengchengLi XingyouZhang XueshuYang ChuanyanGao LeiWang LinglingSong Linsheng - Quinolones (QNs) antibiotics have become one of the most commonly used antibacterial drugs for human and animals in the world. In this study, we focused on 19 common quinolone (QN) antibiotics and collected their bioassay activity data from the PubChem website. Subsequently, using deep learning techniques, we constructed 45 biological activity prediction models based on the PubChem BioAssay dataset. The prediction accuracy of all models exceeded 95%, with the exception of the model for CCRIS mutagenicity studies, which achieved an accuracy of 85.22 ± 0.17%. Collectively, these deep learning models can serve as reliable tools for the prediction and evaluation of quinolone antibiotics. The bioassay activity of 19 QNs antibiotics was predicted by developed models to fill in the missing activity data. It was found that QNs antibiotics were generally active against bacterial DNA repair enzymes and neurobehavioral related protein, including hypothetical protein HP1089, recBCD - exodeoxyribonuclease V subunit RecBCD, recombination protein RecB and SLC5A7. Molecular dynamics simulation results showed that all fluoroquinolone complexes with HP1089, recBCD, RecB, and SLC5A7 reached stable conformations after an initial 0-10 ns relaxation, Our research provides a theoretical basis and technical support for elucidating the regulatory mechanisms of organisms in response to environmental exogenous chemicals, the formulation of environmental protection and food safety policies, the risk assessment of novel compounds, and the development of eco-friendly pharmaceuticals. - Source: PubMed
Publication date: 2026/02/16
Zhang WenjunZhang WenjingDong Chenyang - Antidepressants are the primary treatment for major depressive disorder (MDD), yet their precise neurobiological mechanisms remain incompletely understood. This study aimed to elucidate neural differences between medicated and unmedicated MDD patients by analyzing resting-state functional magnetic resonance imaging data. - Source: PubMed
Publication date: 2025/12/17
Shi RuifengDou YikaiHe YingLuo MengleiYuan CuiWang YunqiongLan DaotaoYang DongShen YanlingSu YihanWang Zuxing - Male CD-1 mice form linear social hierarchies and can rapidly reform them following social reorganization. Through tag-based sequencing in the medial amygdala (MeA), we identified several genes regulating cholinergic signaling, myelination, and thyroid signaling that rapidly shift expression 70 min after animals change social status. Here, we further characterize the expression patterns of individual genes within these pathways in both stable and reorganized hierarchies. We find that genes related to cholinergic signaling show higher expression in the MeA of dominant males in stable hierarchies as well as when reestablishing dominance in reorganized hierarchies. Dominant males also show higher levels of myelination-related genes than socially descending males when reestablishing their social status during social reorganization but less so in stable groups. Conversely, thyroid signaling genes show higher expression in the MeA in subordinate males and previously dominant males who are socially descending. Using RNAscope, we were able to demonstrate broadly similar patterns of gene expression immediately following social reorganization across the MeA, basolateral, and central amygdala for seven genes of interest (chat, slc5a7, ache, mbp, mog, crym, and mybpc1). High levels of coexpression of cholinergic signaling and myelination gene expression in dominant males suggest that these processes work together to promote resilience to the social challenge and promote dominance. In summary, we demonstrate that rapid changes in amygdala gene expression in each pathway are associated with the formation and maintenance of dominance and subordinate social status in stable and reorganized environments. - Source: PubMed
Milewski Tyler MLee WonRada Köll RCurley James P