Ask about this productRelated genes to: THG1L Blocking Peptide
- Gene:
- THG1L NIH gene
- Name:
- tRNA-histidine guanylyltransferase 1 like
- Previous symbol:
- -
- Synonyms:
- ICF45, FLJ11601, FLJ20546, IHG-1, hTHG1
- Chromosome:
- 5q33.3
- Locus Type:
- gene with protein product
- Date approved:
- 2006-09-01
- Date modifiied:
- 2016-01-28
Related products to: THG1L Blocking Peptide
Related articles to: THG1L Blocking Peptide
- Chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes acute febrile illness and often progresses to chronic arthritis-like symptoms for which the underlying molecular mechanisms remain elusive. This study identifies key biomarkers of CHIKV-host interactions, shedding light on potential mechanisms underlying virus-induced joint pathology. RNA sequencing data from peripheral blood samples of paediatric patients with natural Chikungunya infection (15-17 days post-symptom onset; GSE99992: Severe cases = 42, Non-Severe cases = 44) was analysed using binary classification models with StratifiedKFold validation, ensuring a robust and reliable approach to feature selection. A panel of 20 gene features selected by recursive feature elimination with cross-validation (RFECV) showed overlap with known autoantigens and were differentially expressed in CHIKV infection. Network analysis revealed interactions among host biomarkers-THG1L, SLC44A5, KCNN3-and viral components such as nsp4 (CHIKV RNA polymerase) and BCL2-like 11 (an apoptosis facilitator), highlighting a multifactorial virus-host interplay. Fibronectin 1 (FN1) emerged as a central hub gene, known for its role in osteoblast mineralization, skeletal development and its association with renal pathologies. These findings provide novel insights into CHIKV-induced immune dysregulation and offer a foundation for future experimental validation and therapeutic exploration. - Source: PubMed
Publication date: 2025/09/15
Krishnappa Chaitra MallasandraGovindaswamy ShankerGanjiwale Anjali - The tRNA-histidine guanylyltransferase 1-like (), also known as induced in high glucose-1 (), encodes for an essential mitochondria-associated protein highly conserved throughout evolution, that catalyses the 3'-5' addition of a guanine to the 5'-end of tRNA-histidine (tRNA). Previous data indicated that THG1L plays a crucial role in the regulation of mitochondrial biogenesis and dynamics, in ATP production, and is critically involved in the modulation of apoptosis, cell-cycle progression and survival, as well as in cellular stress responses and redox homeostasis. Dysregulations of THG1L expression play a central role in various pathologies, including nephropathies, and neurodevelopmental disorders often characterized by developmental delay and cerebellar ataxia. Despite the essential role of THG1L, little is known about its expression during vertebrate development. Herein, we examined the detailed spatio-temporal expression of this gene in the developing . Our results show that is maternally inherited and its temporal expression suggests a role during the earliest stages of embryogenesis. Spatially, mRNA localizes in the ectoderm and marginal zone mesoderm during early stages of development. Then, at tadpole stages, transcripts mostly localise in neural crests and their derivatives, somites, developing kidney and central nervous system, therefore largely coinciding with territories displaying intense energy metabolism during organogenesis in . - Source: PubMed
Publication date: 2024/07/15
Martini DavideDe Cesari ChiaraDigregorio MatteoMuscò AlessiaGiudetti GuidoGiannaccini MartinaAndreazzoli Massimiliano - Congenital ataxias are rare hereditary disorders characterized by hypotonia and developmental motor delay in the first few months of life, followed by cerebellar ataxia in early childhood. The course of the disease is predominantly nonprogressive, and many patients are incorrectly diagnosed with cerebral palsy. Despite significant advancements in next-generation sequencing in the past few decades, a specific genetic diagnosis is seldom obtained in cases of congenital ataxia. The aim of the study was to analyze the clinical, radiologic, and genetic features of a cohort of Brazilian patients with congenital ataxia. - Source: PubMed
Publication date: 2024/04/23
Raslan Ivana RSilva Thiago Yoshinaga TonholoKok FernandoRodrigues Marcelo MAragão Marcelo MPinho Ricardo SFrança Marcondes CBarsottini Orlando GPedroso José Luiz - tRNA-histidine guanyltransferase 1-like protein (THG1L), located in the mitochondria, plays a crucial role in the tRNA maturation process. Dysfunction of THG1L results in abnormal mitochondrial tRNA modification and neurodevelopmental disorders. To date, few studies have focused on THG1L-related cerebellar ataxia. Whole-exome sequencing revealed compound heterozygous variants NM_017872.5: [c.224A > G]; [c.369-8T > G] in THG1L in a 6-year-old boy with moderate cerebellar ataxia. The variant c.224A > G was demonstrated to downregulate its RNA and protein expression, and c.369-8 T > G resulted in a 7 bp insertion before exon 3. Our case expanded the gene variation and clinical spectrum of THG1L-related cerebellar ataxia. - Source: PubMed
Publication date: 2023/09/05
Han RuiChu ManmanGao JinshuangWang JunlingWang MengyueMa YichaoJia TianmingZhang Xiaoli - The purpose of the current study was to examine transcriptomic-based profiling of differentially expressed innate immune genes between indigenous and commercial chickens. In order to compare the transcriptome profiles of the different chicken breeds, we extracted RNA from blood samples of the Isfahan indigenous chicken (as indigenous) and Ross broiler chicken (as commercial) breeds. RNA-Seq yielded totals of 36,763,939 and 31,545,002 reads for the indigenous and commercial breeds, respectively, with clean reads then aligned to the chicken reference genome (Galgal5). Overall, 1327 genes were significantly differentially expressed, of which 1013 genes were upregulated in the commercial versus the indigenous breed, while 314 were more highly expressed in the indigenous birds. Furthermore, our results demonstrated that the and genes were the most significantly expressed genes in the commercial birds and the and genes were the most significant in the indigenous chickens. Of notable finding in this study was that the high-level gene expressions of heat-shock proteins (HSPs) in the indigenous breeds could serve as a guideline for future genetic improvement. This study identified genes with breed-specific expression, and comparative transcriptome analysis helped understanding of the differences in underlying genetic mechanisms between commercial and local breeds. Therefore, the current results can be used to identify candidate genes for further breed improvement. - Source: PubMed
Publication date: 2023/03/25
Sadr Ayeh SadatNassiri MohammadrezaGhaderi-Zefrehei MostafaHeidari MaryamSmith JacquelineMuhaghegh Dolatabady Mustafa