Ask about this productRelated genes to: LAYN Blocking Peptide
- Gene:
- LAYN NIH gene
- Name:
- layilin
- Previous symbol:
- -
- Synonyms:
- FLJ30977, FLJ31092
- Chromosome:
- 11q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-11-14
- Date modifiied:
- 2014-11-19
Related products to: LAYN Blocking Peptide
Related articles to: LAYN Blocking Peptide
- Improving meat quality using safe phytogenic feed additives is of practical interest in yellow-feathered broiler production. This study aimed to evaluate the effects of dietary Bertoni extract (SBE) supplementation on meat quality traits. A total of 510 one-day-old, female yellow-feathered broilers were randomly allocated to six dietary treatments (0, 50, 100, 200, 300, and 400 mg/kg SBE) for 63 days. Meat sensory attributes, routine physicochemical characteristics, amino acid and fatty acid composition, electronic-nose profiles, and total volatile basic nitrogen (TVB-N) during refrigerated storage were assessed. Overall, the results provide evidence that dietary SBE supplementation is associated with changes in multiple meat quality-related parameters, supporting further evaluation of SBE as a phytogenic feed additive in yellow-feathered broilers. - Source: PubMed
Publication date: 2026/03/27
Peng XiaoGao XinWang JingLi ZhenSong YunfeiZeng JianguoXiang WeiLiu Xiubin - In the AWARD-7 clinical trial participants with type 2 diabetes mellitus (T2D) and moderate-to-severe chronic kidney disease (CKD), a once-weekly treatment with dulaglutide slowed kidney function decline compared with insulin glargine. This study evaluated dulaglutide's effect on 6-month changes in plasma concentrations of 21 Joslin Kidney Panel (JKP) proteins, which were previously associated with end-stage kidney disease (ESKD) risk. - Source: PubMed
Publication date: 2026/01/21
McFarlin Brandon ETye Sok CinSatake EiichiroMd Dom Zaipul IKechter AftonWilson Jonathan MKrolewski Andrzej SDuffin Kevin L - Vladimiria souliei(Franch.)Ling is used as medicine with dried roots, which is a perennial herb in Asteraceae family. It has been generally applied as traditional Chinese medicine with relieving abdominal swelling or pain, and treatment of digestive system disease. However, the pharmacological mechanism of alleviating gastric ulcer (GU) for this herb were still unknown. UPLC-Q-TOF/MS was performed to analyze the main components of Vladimiria souliei extract (VSE). Based on the results of histopathological observation, cytokines assay, and immunohistochemistry staining, the therapeutic effect of VSE on ethanol-induced GU was appraised. Meanwhile, the CCK-8, LDH assay and crystal violet staining were assessed to evaluate the appropriate concentration of VSE in vitro. In GES-1 cells induced by ethanol, the cell viability, ROS and cell membrane damage assay were detected after the interference of VSE. Then, several pivotal proteins relating to necroptosis in GES-1 were evaluated through immunofluorescence staining to illustrate the further pharma-cological mechanisms. As a result, VSE significantly restrained the expansion of ulcer area, reduced the pepsin activity, restored the levels of SOD, decreased the levels of MDA, ROS, TNF-α, IL-1β, IL-6, and IL-18, ultimately ameliorated the gastric mucosa injury. Further analysis exhibited that VSE significantly inhibited the cellular necroptosis by down-regulating the levels of RIP1, RIP3 and MLKL. Conclusions: This research clarified that the VSE could improve gastric mucosal injury through inhibition of RIP1-RIP3-MLKL necrosome activation, which might provide scientific evidences on the application of Vladimiria souliei as a ethnic herb to ameliorate GU. - Source: PubMed
Publication date: 2026/01/19
Wei XiaojingZhao BinjingJiang XinyiLan LunliWang RuiLi Yuanyuan - [This retracts the article DOI: 10.1016/j.heliyon.2024.e36595.]. - Source: PubMed
Publication date: 2025/11/25
Liang ShuaiZhou ShuhuaTang YangshuoXiao MoyanYe Ke - Layilin (encoded by ), a C-type lectin transmembrane receptor, serves as a critical molecular bridge between extracellular matrix (ECM) sensing and intracellular signaling through its interaction with cytoskeletal adaptors. Initially identified for its cytoskeletal functions, layilin has since emerged as a pleiotropic modulator of both physiological homeostasis and pathological conditions. Elevated expression of layilin is associated with poor prognosis in multiple cancers, thereby highlighting its oncogenic potential. Beyond cancer, it plays a pivotal role in rheumatoid arthritis, fibrotic progression, and chronic inflammatory diseases. This review comprehensively synthesizes the structural features, expression dynamics, and disease mechanisms of layilin, emphasizing its biological functions. Key knowledge gaps persist, particularly in understanding its spatiotemporal regulation and crosstalk with immune checkpoints. Future research should prioritize cell-type-specific mechanistic studies using advanced experimental models and the development of layilin-targeted immunotherapies. These efforts will pave the way for precise interventions in diseases driven by the dysregulation of layilin-dependent ECM signaling. - Source: PubMed
Publication date: 2025/12/01
Jin ChenchenZong Yunfeng