Ask about this productRelated genes to: SPON2 Blocking Peptide
- Gene:
- SPON2 NIH gene
- Name:
- spondin 2
- Previous symbol:
- -
- Synonyms:
- DIL1
- Chromosome:
- 4p16.3
- Locus Type:
- gene with protein product
- Date approved:
- 1999-06-18
- Date modifiied:
- 2016-01-12
Related products to: SPON2 Blocking Peptide
Related articles to: SPON2 Blocking Peptide
- Many biomarkers have been evaluated as potential early detection markers for ovarian cancer. Better understanding of factors associated with inter-individual variation in circulating concentrations of these biomarkers is useful for optimizing their clinical utility for early detection. The study objective was to characterize the associations of sociodemographic-, lifestyle-, and health-related factors in relation to circulating ovarian biomarker concentrations in cancer-free women. - Source: PubMed
Publication date: 2026/04/22
Akonde MaxwellGraybill Whitney SpannuthClay-Gilmour AlyssaZhang JiajiaAlberg Anthony J - Colorectal cancer (CRC) peritoneal metastasis (PM) accounts for 25-35% of stage IV cases. CRC PM carries a median overall survival of 16 months with systemic chemotherapy and an almost 0% 5-year survival rate. The molecular mechanisms driving CRC PM remain poorly defined. CRC heterogeneity is classified into four Consensus Molecular Subtypes (CMS1-4), with CRC PM predominantly exhibiting the CMS4 signature-characterized by increased stromal/mesenchymal enrichment and cellular plasticity-features linked to frequent disease progression and therapeutic resistance. Here, we investigated the molecular mechanisms driving CRC PM and CMS4 signature. TWIST1 was identified to be significantly upregulated in CRC PM. We established TWIST1-SPON2 as a novel transcriptional axis contributing to CRC PM tumorigenesis, through mediating tumor-stroma interactions. We identified SPP1, secreted by the tumor stroma, as an upstream regulator of the TWIST1-SPON2 cascade via AKT activation in tumor cells in vitro and in vivo. This defined SPP1-TWIST1-SPON2 signaling circuit is pivotal in shaping the tumor microenvironment and promoting CRC PM progression. The findings establish the SPP1-TWIST1-SPON2 axis as potential biomarkers and therapeutic targets in CRC PM. - Source: PubMed
Publication date: 2026/04/03
Zhou ZhuanLa Ferlita AlessandroPalavalli Manoj HChen XiongfengTyler LaurenEjaz AslamBeane JoalPolanco Patricio MHuang HuocongKim Alex C - Although a range of glomerular diseases profoundly affect glomerulus-associated cells, a comprehensive understanding of their molecular alterations is still lacking. Here, we performed in-depth analysis of glomerular data from mouse models of primary and secondary glomerulopathies and constructed a multi-disease cellular landscape of glomerular cells. We identified a putative subset of proliferative glomerular endothelial cells(gECs) that highly expresses genetic susceptibility genes associated with multiple glomerular diseases. Podocytes exhibited shared injury-associated cell types across different disease models. A podocyte subset highly expressing , , , , , and was predominantly derived from ob/ob mice, whereas another podocyte subset with high expression of , , , , and was mainly observed in adriamycin-induced mice. Mesangial cells shared common injury-related alterations across diseases (high expression of , , , and ), while ob/ob mice exhibited a distinct mesangial cell subset (high expression of and ). In contrast, the gECs displayed similar molecular changes across different diseases without giving rise to disease-specific subtypes. Intercellular ligand-receptor analysis underpins the recruitment of immune cells by injured mesangial cells and podocytes via specific engagement of pairs such as CXCL and MIF, respectively. Our study systematically elucidates the molecular alterations of glomerulus-associated cells across various diseases, providing a foundation and strategic insights for future targeted therapies tailored to specific glomerular disease contexts. - Source: PubMed
Publication date: 2026/02/24
Huang YanLi ShuoLi ShuyingDuan ShuzhongHuang LanWang JingMa LiangyanLiu CeChen Qilin - Spondin-2 (SPON2) has been reported to be upregulated in various carcinomas, contributing to cancer progression and metastasis. However, its underlying mechanism in gastric cancer (GC) remains poorly understood. This study aimed to explore the relationship between SPON2 expression, prognostic outcomes, and radiotherapy sensitivity in GC. - Source: PubMed
Publication date: 2025/12/29
Zhang YongqinZuo YunHua Dong - Unstable angina (UA) represents a prevalent cardiovascular condition characterized by significant morbidity and mortality, necessitating the development of effective early diagnostic biomarkers. This study sought to identify plasma protein biomarkers associated with UA utilizing Olink proteomics. A cohort of 120 participants, comprising 60 individuals diagnosed with UA and 60 healthy controls, was recruited. A total of 92 inflammation-related plasma proteins were quantified through a proximity extension assay. In the discovery cohort, differential expression analysis revealed significant alterations in 49 proteins, which were predominantly enriched in cytokine-mediated signaling and MAPK pathways, as demonstrated by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses. Least absolute shrinkage and selection operator regression and random forest methodologies prioritized three biomarkers─SPON2, PTX3, and GBGT1─that exhibited elevated levels in UA patients compared to controls. Receiver operating characteristic analysis demonstrated area under the curve values of 0.859, 0.937, and 0.900 for SPON2, PTX3, and GBGT1, respectively. A combined diagnostic model incorporating these three proteins achieved an AUC of 0.979 and demonstrated robust performance in an independent validation cohort. These results suggest that SPON2, PTX3, GBGT1, and their composite model hold promise as diagnostic biomarkers for UA. - Source: PubMed
Publication date: 2025/12/24
Cao TingLi WenliPang JungangTan ShaohuaLiu Jun