Ask about this productRelated genes to: RHOB Blocking Peptide
- Gene:
- RHOB NIH gene
- Name:
- ras homolog family member B
- Previous symbol:
- ARH6, ARHB
- Synonyms:
- RhoB, RHOH6, MST081
- Chromosome:
- 2p24.1
- Locus Type:
- gene with protein product
- Date approved:
- 1997-04-16
- Date modifiied:
- 2016-10-05
Related products to: RHOB Blocking Peptide
Related articles to: RHOB Blocking Peptide
- During infection, alterations of the endothelium’s barrier function are multifaceted and virus-specific. Rubella virus (RuV) infection during pregnancy damages the endothelium in the placental and fetal vasculature, thereby contributing to the development of congenital rubella syndrome. However, the extent and mechanisms behind RuV-induced endothelial barrier disruption have not been previously documented. - Source: PubMed
Publication date: 2026/04/27
Kovacevic IgorMüller MarieMair LeonieHenschke VivienKowalski AnnkatrinBoeckel Jes-NielsKropf KarolinPosern GuidoReibetanz UtaClaus Claudia - Current therapeutic regimens for castration-resistant prostate cancer (CRPC) are plagued by multiple limitations. RhoB has emerged as a promising molecular target for prostate cancer (PCa) therapy. Icaritin, a bioactive prenylated flavonoid isolated from Epimedii Folium, exhibits potent antitumor and osteogenic properties. However, the anti-CRPC efficacy of icaritin and its underlying molecular mechanisms remain incompletely elucidated. Herein, we evaluated the anti-CRPC potential of icaritin and investigated the involvement of RhoB signaling. Results demonstrated that icaritin significantly suppressed the viability, proliferation, and clonogenic capacity of CRPC cells. Furthermore, in an RM-1 xenograft model, icaritin inhibited tumor growth and reduced serum levels of prostate-specific antigen (PSA) and testosterone. Integrated RNA-seq analysis and The Cancer Genome Atlas-Prostate Adenocarcinoma (TCGA-PRAD) dataset identified RhoB as a candidate therapeutic target in CRPC. Subsequent mechanistic investigations revealed that icaritin inhibits CRPC progression by modulating RhoB-mediated Akt signaling. Collectively, these findings indicate that the anti-CRPC activity of icaritin is at least partially mediated through the RhoB/Akt signaling, providing a pharmacological basis for the further development of icaritin as a potential therapeutic agent against CRPC. - Source: PubMed
Publication date: 2026/04/18
Hui ChenFan ZhangYingyao MaShu GanTao Su - - Source: PubMed
Publication date: 2026/04/23
Li YingqiWang ZiweiYu JinminLiang XiruCheng YutongMa JuanPeng YuxinWang JinhaiLiu NaLi LuWei ZhaoShi HaitaoXie Ning - In this study, the fractures of the Fahliyan limestone formation, the third hydrocarbon-bearing reservoir in southwestern Iran, were investigated. Despite previous studies on the Fahliyan Formation, a comprehensive workflow integrating conventional petrophysical logs, FMI image analysis, and velocity deviation logs for systematic fracture characterization has not yet been fully developed. In the first step, petrophysical parameters, including water and hydrocarbon saturation and the overall lithology of the reservoir (limestone with minor shale content), were evaluated using conventional petrophysical logs, such as gamma ray (GR), density (RHOB), neutron (NPHI), photoelectric factor (PEF), and resistivity logs (MSFL, LLS, LLD). In the second step, processing of the Formation Micro Scanner (FMI) image logs led to the identification of bedding with dips less than 30° toward the northeast and fractures, which mainly extended with dips of 75° in the directions S65E/N65W and S25W. A more detailed analysis of the fracture patterns and their relationship with bedding was made possible by combining manual and automated methods. Analysis of the in-situ stresses indicated that borehole breakouts had mirror-dip orientations of N40W-S40E, and induced fractures had mirror-dip orientations of N70E-S70W, which is consistent with the Zagros trend. In the third step, the velocity deviation log (VDL) results showed negative values in the fractured upper part and zero to positive values in the lower part of the Fahliyan formation. This study, through integration of conventional petrophysical logs and FMI images, enabled the quantification and classification of fracture systems in the Fahliyan formation and demonstrated their direct relationship with the velocity deviation logs and in-situ stress orientations. This methodology facilitates the prediction of high-permeability fractured zones and optimization of reservoir development. - Source: PubMed
Publication date: 2026/04/15
Mohsenipour Seyed AbouzarSamani BabakShooli BehnazFaghih Ali - Esophageal squamous cell carcinoma (ESCC) is a cancer that is common worldwide. Its morbidity and mortality rates remain high, seriously threatening human health. In the tumor microenvironment (TME), CD8+ T cells undergo a series of dynamic changes that have important implications for tumor progression and the efficacy of immunotherapy. Our research aims to construct novel molecular subtypes through the gene expression profiling of CD8+ T cells during differentiation and to predict the prognostic and therapeutic effects in ESCC patients. - Source: PubMed
Publication date: 2026/03/27
Cao SinanJiang HaoLi YangYang KeTian LiliLi Linwei