Ask about this productRelated genes to: PPID Blocking Peptide
- Gene:
- PPID NIH gene
- Name:
- peptidylprolyl isomerase D
- Previous symbol:
- -
- Synonyms:
- CYP-40
- Chromosome:
- 4q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 1995-08-23
- Date modifiied:
- 2016-10-05
Related products to: PPID Blocking Peptide
Related articles to: PPID Blocking Peptide
- Pituitary pars intermedia dysfunction (PPID) is one of the most common equine endocrine disorders. It is caused by oxidative damage to dopaminergic neurons in the hypothalamus and results in loss of inhibition of the pituitary pars intermedia. This leads to increased circulating concentrations of adrenocorticotropic hormone (ACTH) and related peptides. Diagnosis is based on increased resting and/or thyrotropin releasing hormone-stimulated ACTH concentrations. Assessment of insulin regulation is also important, as insulin dysregulation occurs in at least one-third of PPID cases and is associated with laminitis risk. Management requires treatment with the dopamine agonist pergolide and an appropriate diet. - Source: PubMed
Publication date: 2026/09/01
Vaughn Sarah AHart Kelsey A - Limited published data exist regarding the diagnostic utility of beta-endorphin (β-END) for pituitary pars intermedia dysfunction (PPID), either compared with or in combination with adrenocorticotropic hormone (ACTH). - Source: PubMed
Billmann PaulaDurham Andy EChristen GaranceGerber VinzenzGross JosefFouché Nathalie - Variables associated with hormonal, clinical, and survival outcomes of equids with pituitary pars intermedia dysfunction (PPID) are incompletely investigated. - Source: PubMed
Stapley EmmaLowndes CaitrinInanc EceGillespie-Harmon CarolineWaxman SarahFarr Amandavan Eps AndrewBertin François-René - Pituitary pars intermedia dysfunction (PPID) is a prevalent endocrine disease in older horses sharing pathogenetic features with Parkinson disease, including dopaminergic neurodegeneration and α-synuclein aggregation. This study was conducted to determine whether horses with PPID exhibit changes in short-chain fatty acid (SCFA) profiles as described in Parkinson disease, providing further evidence for involvement of a microbiota-gut-brain axis in the pathogenesis of PPID. - Source: PubMed
Publication date: 2026/08/18
Wang WenqingNitert Marloes DekkerGobius SaharaGonzalez-Astudillo VivianaBertin François-René - Kawasaki disease (KD) is a systemic vasculitis of childhood driven by aberrant immune activation. Natural killer (NK) cell dysregulation plays a critical role, but its upstream molecular mechanisms remain unclear. Isonicotinylation (Kinic), a novel lysine acylation acting as a metabolic sensor, represents an unexplored regulatory layer in KD. - Source: PubMed
Publication date: 2026/07/22
Yang YanliHu Pengjuan