Ask about this productRelated genes to: SPOCK3 Blocking Peptide
- Gene:
- SPOCK3 NIH gene
- Name:
- SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
- Previous symbol:
- -
- Synonyms:
- testican-3
- Chromosome:
- 4q32.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-01-24
- Date modifiied:
- 2018-02-23
Related products to: SPOCK3 Blocking Peptide
Related articles to: SPOCK3 Blocking Peptide
- Endothelial cells (ECs) are key structural and functional components of the blood-brain barrier (BBB). Mouse models are frequently used to study EC biology within the BBB, yet the extent to which human and mouse BBB ECs share conserved transcriptomic features remains unclear. Here, we systematically compare transcriptomic profiles of BBB capillary ECs from adult mice and humans. - Source: PubMed
Publication date: 2026/03/12
Miao YuyangWang JianhaoLi WeihanMäe Maarja AndaloussiJeansson MarieMuhl LarsHe Liqun - Isolated REM sleep behavior disorder (iRBD) is among the strongest clinical markers of prodromal α-synucleinopathies. Pinpointing causal proteins may open the door to early diagnosis and disease-modifying therapies. - Source: PubMed
Publication date: 2026/01/07
Ye HongLiu ZhenzhenHuang YajingXu NaJiang ChaoyaXu QiuhanZhou Xuxia - Basement membrane-related genes (BMRGs) play a crucial function in the progression of various malignancies. This study aimed to explore the relationship between BMRGs and colon cancer. - Source: PubMed
Publication date: 2025/11/19
Wei JiajieWang HouZeChai JianGuo CeGong TianYiWang HengLi XiaoLongWu HaiFengXing BaoJianZhang YaJuanZhang HuiQingGuo Xing - Ovarian cancer (OC), a deadliest gynecological malignancy, lacks reliable predictive biomarkers for its heterogeneous clinical outcomes. Per- and polyfluoroalkyl substances (PFAS) are persisting endocrine disruptors potentially affecting female reproductive health, but their roles in OC remain unclear. We aimed to investigate the possible associations between PFAS and OC prognosis. - Source: PubMed
Publication date: 2025/09/12
Xie HongyuWang DanyunFeng LiangWang HuiLi Xiao - Numerous extracellular matrix (ECM) proteins, referred to as the matrisome, are increased in Alzheimer's disease (AD). We recently demonstrated that many of these proteins colocalize with Aβ plaques and cerebral amyloid angiopathy (CAA), and some are present in dystrophic cellular processes within and around plaques. However, their precise roles in AD pathogenesis and their spatial and temporal distribution in postmortem brain tissue remain incompletely understood. Here, we performed a comprehensive immunohistochemistry analysis on postmortem brain samples spanning the spectrum of AD neuropathological change (ADNC: low, intermediate, and high). We assessed the accumulation of five matrisome proteins (MDK, SPOCK3, COL25aA1, SDC4, and EGFL8) across four brain regions differentially affected in AD (occipital cortex, hippocampus, striatum, and cerebellum) and examined their association with Aβ plaques, CAA, tau neurites, and neurofibrillary tangles (NFT). MDK in plaques increased consistently with ADNC severity across all regions. In contrast, SPOCK3, COL25A1, EGFL8, and SDC4 showed marked accumulation only in the occipital cortex and hippocampus, with sparse presence in the striatum and absence in the cerebellum. Notably, SPOCK3 exhibited pronounced regional specificity, with significantly higher levels in the hippocampus than in other areas. Morphological patterns of staining and degree of colocalization with Aβ and tau indicate that select matrisome proteins associate with either distinct types of Aβ deposits (neuritic versus diffuse plaques), while others may overlap more closely with tau pathology and/or dystrophic processes around plaques. Overall, our findings reveal region- and pathology-specific patterns of matrisome protein accumulation during AD progression. These proteins represent intriguing biomarkers of AD and are based on modeling studies potential therapeutic targets. - Source: PubMed
Publication date: 2025/07/24
Tsering WangchenPhilips Jennifer LGolde Todd EVillareal Jonathan AProkop Stefan