Ask about this productRelated genes to: GALNT13 Blocking Peptide
- Gene:
- GALNT13 NIH gene
- Name:
- polypeptide N-acetylgalactosaminyltransferase 13
- Previous symbol:
- -
- Synonyms:
- KIAA1918, GalNAc-T13
- Chromosome:
- 2q23.3-q24.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-12-02
- Date modifiied:
- 2018-02-13
Related products to: GALNT13 Blocking Peptide
Related articles to: GALNT13 Blocking Peptide
- Glycosylation, a key and prevalent modification in brain proteins and lipids, is essential for brain development and function. O-GalNAc glycosylation, initiated by the family of polypeptide N-acetylgalactosaminyltransferases (GalNAc-Ts, s), is the most abundant type of O-glycosylation in the brain. Despite growing evidence linking variations to neuropsychiatric disorders, the molecular roles and underlying mechanisms by which O-GalNAc glycosylation contributes to brain functions remain poorly characterized. Here, we focus on GalNAc-T13, a member of the GalNAc-T family that is highly expressed in the brain. We established a brain-specific conditional knockout mouse model and found that these mice exhibited reduced neurite length, simplified dendritic branching, and decreased dendritic spine density in the cerebral cortex across embryonic and adult stages. Behavioral analyses further revealed impaired spatial memory consolidation following knockout. Mechanistically, we identified seizure protein 6 (SEZ6), a neurodevelopment-related protein, as a key substrate of GalNAc-T13 using a lectin-based mass spectrometry glycoproteomic approach. Our results demonstrated that GalNAc-T13 regulates the O-GalNAc glycosylation levels of SEZ6 with high catalytic efficiency in vitro and in vivo, improving protein stability and its interaction with PRSS12 at the cell surface to promote neurite outgrowth. Collectively, these findings suggest a critical role for GalNAc-T13 in maintaining cortical neurite architecture and memory retention, providing a mechanistic example for understanding the function of O-GalNAc glycosylation in the brain. - Source: PubMed
Publication date: 2026/03/06
Deng YaoZou XiaZhang HanLu XiaoyanZhao XingmingJia WenjuanXu YingjiaoYang FangNarimatsu HisashiZhang Yan - A complete telomere-to-telomere (T2T) genome is essential for advancing pig genomic research. Here we assembled a pig T2T gap-free genome T2T-pig1.0 (2.63 Gb) for a boar in Wuzhishan, China, covering all 20 chromosomes. T2T-pig1.0 with an accuracy of >99.999% uncovers 194.42 Mb of previously unresolved regions (PURs), and 1,189 new genes are added to the current reference genome Sscrofa11.1. We annotated 111 protein-coding genes with 11 male-specific conserved orthologous genes on chromosome Y (43.25 Mb). Pig-specific centromeric satellite repeat units are revealed. Centromeric regions of all telocentric chromosomes harbor a unique structure, 'telomere-SAT1B-(mSAT)ₙ-SAT3-q_arm', and a few young long terminal repeats. With the addition of 339,092 single-nucleotide polymorphisms in PURs, the population structure is updated with cross-continental introgression, and a selective sweep analysis reveals 280 new regions and 133 new genes potentially associated with body stature. GALNT13, with strong selection signals, has a role in inhibiting porcine chondrocyte proliferation while promoting chondrocyte differentiation. - Source: PubMed
Publication date: 2025/12/12
Luo Ya-BiaoHuang NingZha Cheng-WanYang Li-XianXue Peng-XiangXu QiaoYang Xiao-YangZhang Long-MiaoWang Yu-BeiChao ZheSun Rui-PingWang FengJia Shan-GangFang Mei-Ying - Pleomorphic adenoma (PA), the most common benign salivary gland tumor, harbors unpredictable risks of recurrence and malignant transformation into carcinoma ex pleomorphic adenoma (CXPA), posing significant clinical challenges. To better delineate the tumor transformation trajectory, we performed single-cell RNA sequencing of normal salivary gland, primary PA, recurrent PA (rPA), and CXPA. Cell trajectory reconstruction, differential expression gene identification, and key gene network analysis were integrated to characterize molecular transitions and intercellular crosstalk driving PA recurrence and malignant transformation. Immunohistochemistry was used to validate key findings. GALNT13 + myoepithelial cells were identified as CXPA-specific malignant progenitors, delineating early malignant conversion. Concurrently, MIF + myoepithelial cells exhibited enhanced tissue-destructive capabilities. Fibroblasts enforced fibrotic restraint in primary PA and drove extracellular matrix degradation in CXPA. The tumor microenvironment exhibited stage-specific adaptations, with CXPA favoring pro-inflammatory MIF-CD74/CD44 signaling and rPA adopting immunosuppressive traits. Stromal reprogramming and immune-editing dynamics collectively orchestrated microenvironmental adaptation, linking cellular heterogeneity to clinical aggressiveness. This study provides the first comprehensive molecular atlas of PA-to-CXPA transformation, revealing malignant specialization of the myoepithelial subpopulation, fibroblast-mediated stromal reprogramming, and immune-editing driven microenvironmental adaptation. These findings provide a framework for precision stratification of the malignant potential of PA, while positioning microenvironmental intervention as a cornerstone of future clinical strategies. - Source: PubMed
Publication date: 2025/10/14
Li YikeLi ZhixuanZhao GuileHan QiDing ZhangfanWang ChengLi Chunjie - : Previous multi-ethnic genome-wide association studies (GWAS) have identified the GALNT13 rs10196189 polymorphism as a potential genetic marker linked to sprint-power performance. However, its relevance in East Asian populations, particularly the Han Chinese, remains untested. This study aimed to replicate the association of rs10196189 with elite sprint-power athlete status in Han Chinese males and examine its potential influence on physical performance traits and tissue-specific gene regulation. : A total of 188 healthy Han Chinese males (49 elite sprint-power athletes and 139 non-athletic controls) were genotyped using the TaqMan assay. Assessments included strength, sprint, jump, anaerobic power, DXA-derived body composition, and muscle ultrasound. Logistic regression and ROC analyses evaluated the predictive value of rs10196189. Linear regression models adjusted for age and BMI tested genotype-phenotype associations. Tissue expression and functional networks were analyzed using GTEx and HumanBase databases. : The G allele frequency was significantly higher in athletes (12.2%) than in controls (5.4%, = 0.042). Dominant and additive models effectively predicted athlete status (OR = 2.53-2.58, < 0.05). Although most traits showed no significant associations post-correction, medial gastrocnemius thickness showed a nominal association (β = 0.371, = 0.011). Functional analyses revealed high GALNT13 expression in brain tissue and co-expression networks enriched in synaptic signaling and glycosylation pathways. : This is the first study to validate the association of GALNT13 rs10196189 with elite athletic status in Han Chinese males. Findings provide novel population-specific evidence and propose tissue-specific glycosylation and neural mechanisms as pathways linking this variant to sprint-power phenotypes. - Source: PubMed
Publication date: 2025/08/20
Chen LunWang MingruiLiu LongtianjiaoJiang XiaoyuCao ZihangAzhati SamuhaerChen HangyuShe KaixinZhu JinyaoChen MingLi JindaKong JunhaoZhang JiahaoYan YuangDong YiMieryazi ApudumalikeLiu SongyuZhang YanyanMa YixuanShi Lijun - Ewe longevity indicators are complex traits that are lowly heritable, expressed late in life, and sex-limited, making them challenging to include in breeding programs. In this context, genome-wide association studies (GWASs) can provide more information on the complex genetic control of these traits. Therefore, the primary objective of this study was to carry out association analyses for 8 longevity-related traits in 12,734 Katahdin ewes. A total of 126 associations at the chromosome-wide level and 3 at genome-wide level were found. These associations involved 86 single-nucleotide polymorphisms (SNPs) located across 22 chromosomes, with 24 of these SNPs associated with two or more traits. The variants overlapped with genes previously associated with prolificacy (, , , , and ), ovarian follicle pool (, , and ), synthesis and release of reproductive hormones (, , and ), and early pregnancy events (, , , , , , , , and ). Moreover, genes related to response to stress or pathological conditions (, , , , , , , , , , , , , and zinc-finger proteins), growth performance (, , , and ), and carcass traits ( and ) were also implicated. Metabolic pathways such as oxytocin signaling and cardiac-related pathways were enriched. These findings suggest that longevity indicators in Katahdin ewes are highly polygenic traits influenced by a combination of voluntary and involuntary culling reasons. Candidate genes and metabolic pathways influencing reproductive performance and health may play a key role in the functional longevity of Katahdin ewes. - Source: PubMed
Publication date: 2025/07/03
Pinto Luis F BLewis Ronald MRocha Artur OFreking Brad AMurphy Tom WWilson Carrie SNilson Sara MBurke Joan MBrito Luiz F