Ask about this productRelated genes to: SRP19 Blocking Peptide
- Gene:
- SRP19 NIH gene
- Name:
- signal recognition particle 19
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 5q22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-12-05
- Date modifiied:
- 2016-10-05
Related products to: SRP19 Blocking Peptide
Related articles to: SRP19 Blocking Peptide
- Loss of the tumor suppressor gene (TSG) Adenomatous Polyposis Coli () is a hallmark event in colorectal cancers. Since it is not possible to directly target a TSG, no treatment options are available for these patients. Here, we identify and the protein secretion machinery as a unique vulnerability in cancers with heterozygous loss. is located 15 kb from and is almost always codeleted in these tumors. Heterozygous loss leads to lower levels of mRNA and protein. Consequently, cells with loss are vulnerable to partial suppression of . Moreover, we show that is rate limiting for the formation of the Signal Recognition Particle, a complex that mediates ER-protein translocation, and thus, heterozygous loss leads to less protein secretion and higher levels of ER-stress. As a result, low-dose arsenic trioxide induces ER-stress and inhibits proliferation in cultured cell lines and animal models. Our work identifies a strategy to treat cancers with deletion and provides a framework for identifying and translating vulnerabilities associated with loss of a TSG. - Source: PubMed
Publication date: 2025/04/10
Xi XinqiLiu LingTuano NatashaTailhades JulienMouradov DmitriSteen JasonSieber OliverCryle MaxNguyen-Dumont TuSegelov EvaRosenbluh Joseph - To conduct a genome-wide association study (GWAS) of individuals with neuropathic ocular pain (NOP) symptoms to identify genomic variants that may predispose to NOP development. - Source: PubMed
Publication date: 2023/08/13
Huang Jaxon JRodriguez Daniel ASlifer Susan HMartin Eden RLevitt Roy CGalor Anat - Alopecia areata (AA) is one of the most prevalent autoimmune diseases affecting humans. Given that hair follicles are immune-privileged, autoimmunity can result in disfiguring hair loss. However, the genetic basis for AA in the Taiwanese population remains unknown. - Source: PubMed
Publication date: 2023/09/21
Yang Jai-SingLiu Ting-YuanChen Yu-ChiaTsai Shih-ChangChiu Yu-JenLiao Chi-ChouTsai Fuu-Jen - The mechanisms of coordinated changes in proteome composition and their relevance for the differentiation of neutrophil granulocytes are not well studied. Here, we discover 2 novel human genetic defects in signal recognition particle receptor alpha (SRPRA) and SRP19, constituents of the mammalian cotranslational targeting machinery, and characterize their roles in neutrophil granulocyte differentiation. We systematically study the proteome of neutrophil granulocytes from patients with variants in the SRP genes, HAX1, and ELANE, and identify global as well as specific proteome aberrations. Using in vitro differentiation of human induced pluripotent stem cells and in vivo zebrafish models, we study the effects of SRP deficiency on neutrophil granulocyte development. In a heterologous cell-based inducible protein expression system, we validate the effects conferred by SRP dysfunction for selected proteins that we identified in our proteome screen. Thus, SRP-dependent protein processing, intracellular trafficking, and homeostasis are critically important for the differentiation of neutrophil granulocytes. - Source: PubMed
Linder Monika IMizoguchi YokoHesse SebastianCsaba GergelyTatematsu MegumiŁyszkiewicz MarcinZiȩtara NataliaJeske TimHastreiter MaximilianRohlfs MeinoLiu YanshanGrabowski PiotrAhomaa KaarinMaier-Begandt DanielaSchwestka MarkoPazhakh VahidIsiaku Abdulsalam IBriones Miranda BrendaBlombery PiersSaito Megumu KRusha EjonaAlizadeh ZahraPourpak ZahraKobayashi MasaoRezaei NimaUnal EkremHauck FabianDrukker MichaWalzog BarbaraRappsilber JuriZimmer RalfLieschke Graham JKlein Christoph - There was an error in the original publication, in Equation (5) [...]. - Source: PubMed
Publication date: 2022/03/29
Jegannathan GobinathSeliuchenko VolodymyrVan den Dries ThomasLapauw ThomasBoulanger SvenIngelberts HansKuijk Maarten