Ask about this productRelated genes to: RNF207 Blocking Peptide
- Gene:
- RNF207 NIH gene
- Name:
- ring finger protein 207
- Previous symbol:
- C1orf188
- Synonyms:
- FLJ46380, FLJ32096
- Chromosome:
- 1p36.31
- Locus Type:
- gene with protein product
- Date approved:
- 2006-07-04
- Date modifiied:
- 2015-08-25
Related products to: RNF207 Blocking Peptide
Related articles to: RNF207 Blocking Peptide
- Ring finger protein 207 (RNF207) is an E3 ubiquitin ligase that regulates the stability and activity of target proteins via ubiquitination and non-proteolytic mechanisms. However, its role in osteosarcoma pathogenesis and association with patient prognosis remain poorly understood. - Source: PubMed
Publication date: 2025/09/04
Liu WendaXia KezhouTong KaiHuang XinghanWei ZhunWei ZichengGuo Weichun - A missense mutation in the titin gene (TTN) and a splice-site mutation in the pyruvate dehydrogenase kinase 4 gene (PDK4) have been associated with dilated cardiomyopathy (DCM) in Dobermanns from the United States. Additionally, a missense mutation in the gene RNF207 has been reported in association with DCM from a European Dobermann cohort. Based on this we examined the association of these variants with DCM in United Kingdom (UK) Dobermanns. We hypothesized that the TTN and PDK4 gene variants would not be associated with DCM in UK Dobermanns and that there would be an association between the RNF207 mutation and DCM. We included 74 client owned dogs (30 control dogs and 44 dogs with DCM) in the study. Allele frequencies for each variant were calculated. Chi-square testing was used to assess for differences in allele frequencies and genotype proportions between groups. Overall allele frequency in this cohort was 35% for the TTN variant, 18% for the PDK4 variant, and 37% for the RNF207 variant. There was no difference in allele or genotype frequencies between control and DCM dogs for TTN or PDK4 (p = 0.79 for both allele frequencies, p = 0.91 for TTN and p = 0.78 for PDK4 genotype frequencies). There was a significant difference in the allele frequencies of the RNF207 variant between DCM cases and controls (OR 2.4 (95% CI 1.07 - 5.15), p = 0.03) and genotype frequencies for RNF207, with a homozygous genotype found almost exclusively in DCM dogs (p = 0.034). We conclude that the previously reported RNF207 variant appears associated with DCM in UK Dobermanns, but there was no association with the previously reported TTN or PDK4 mutations. This is important when considering selective breeding in different populations of Dobermanns. However, the small sample size may impact the generalizability of the results. - Source: PubMed
Publication date: 2025/03/13
Dutton Luke CCrosland AndrewDukes-McEwan JoannaConnolly David J - Viruses are critical for the regulation of cancer development and for therapy. Human adenovirus C (HadVC) has been detected in central nervous system and glioma tissue. The objective of the present study was the development of a robust prognostic model based on HadVC infection (HadVCi)-relevant genes. - Source: PubMed
Publication date: 2023/12/13
Wu MengwanShi YingLiu YuyangLi ZhaoshenWu HongYu ZhuoyangWang ZhaoXu Chuan - Dilated cardiomyopathy (DCM) is a life-threatening heart disease and a common cause of heart failure due to systolic dysfunction and subsequent left or biventricular dilatation. A significant number of cases have a genetic etiology; however, as a complex disease, the exact genetic risk factors are largely unknown, and many patients remain without a molecular diagnosis. - Source: PubMed
Publication date: 2023/09/18
Niskanen Julia EOhlsson ÅsaLjungvall IngridDrögemüller MichaelaErnst Robert FDooijes Dennisvan Deutekom Hanneke W Mvan Tintelen J PeterSnijders Blok Christian J Bvan Vugt Marionvan Setten JessicaAsselbergs Folkert WPetrič Aleksandra DomanjkoSalonen MillaHundi SruthiHörtenhuber Matthias Kere JuhaPyle W GlenDonner JonasPostma Alex VLeeb TossoAndersson GöranHytönen Marjo KHäggström JensWiberg MariaFriederich JanaEberhard JennyHarakalova Magdalenavan Steenbeek Frank GWess GerhardLohi Hannes - Clear cell adenocarcinoma of the cervix (CCAC) is a special type of HPV-independent cervical cancer. It has a low incidence rate, can be difficult to diagnose early, has a poor prognosis. Its peak incidence is in adolescence, which poses a great threat to women's health. Therefore, it is very important to explore the pathogenesis of cervical clear cell adenocarcinoma to guide subsequent treatment and prevention. This study analyzed 3 juvenile patients with CCAC diagnosed at the First Affiliated Hospital of Zhengzhou University. Using next-generation sequencing methods, we analyzed the pathogenesis of the patients and their close relatives by analyzing the genetic alterations of patients. CMTM5 was identified as the only shared mutated gene. Using published literature and comparative analyses of related disease-causing genes, 6 of the 19 genes (ALKBH7, MYCBP, MZF1, RNF207, RRS1, and TUSC2) were screened as genes with mutations in patients and had higher mutation rates in reproductive cancers. Pathway analysis showed that downregulated genes in non-HPV cervical cancer were mainly related to the immune system response, suggesting that non-HPV cervical cancer differs from HPV-infected cervical cancer in that the immune response is weaker, which is consistent with the weak correlation with viral infection. - Source: PubMed
Publication date: 2023/08/16
Su YuehuiZhang YimingZhou MengjiaoZhang RuijinChen SiangZhang LiliWang HaoZhang DongdongZhang TingLi XinqiangZhang ChunyanWang BingjieYuan ShuyuZhang MengzhuoZhou YingyingCao LiliZhang MengzhenLuo Jianjun