Ask about this productRelated genes to: KBTBD8 Blocking Peptide
- Gene:
- KBTBD8 NIH gene
- Name:
- kelch repeat and BTB domain containing 8
- Previous symbol:
- -
- Synonyms:
- TA-KRP, KIAA1842
- Chromosome:
- 3p14.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-08-22
- Date modifiied:
- 2016-10-05
Related products to: KBTBD8 Blocking Peptide
Related articles to: KBTBD8 Blocking Peptide
- The tumor immune microenvironment (TIME) and N-methylguanosine (m7G) modification play crucial roles in the progression of acute myeloid leukemia (AML). This study aims to establish an IME-related and m7G-related prognostic model for improved risk stratification and personalized treatment in AML. - Source: PubMed
Publication date: 2025/06/13
Chen ZhixiangChen ZhimeiHuang XiaoboYan XiongbinLai XiaolinWang Shaoyuan - We have previously demonstrated that RRP15 (Ribosomal RNA Processing 15 Homolog) was significantly elevated in hepatocellular carcinoma (HCC) and correlated directly with poor prognosis. RRP15 suppression curtails HCC progression through induction of cellular senescence and apoptosis. However, the impact of RRP15 on the precise therapeutic potential of lenvatinib has remained underexplored. - Source: PubMed
Publication date: 2024/12/11
Zhao SailiWang XuranWu RuiWang FenglanTang XiaoxuanChen JunhuiJiang RunqiuKang WeiXu GuifangWang LeiWang ZhangdingZou XiaopingZhang Bin - Extracellular vesicles (EVs) mediate cell interactions in biological processes, such as receptor activation or molecule transfer. Estimates of variation by age and sex have been limited by small sample size, and no report has assessed the contribution of genetic factors to levels of EVs. Here, we evaluated blood levels of 25 EV and 3 platelet traits in 974 individuals (933 genotyped) and reported the first genome-wide association study (GWAS) on levels of these traits. EV levels all decreased with age, whereas the trend for their surface markers was more heterogeneous. Platelets and CD31dim platelet EVs significantly increased in females compared to males, although CD31 expression on both platelets and platelet EVs decreased in females. Levels of the other EV subsets were similar between sexes. GWAS revealed three statistically significant genetic signals associated with EV levels in the and genes and in the intergenic region between and . These add to a signal in the 3'UTR of associated with CD31 expression on platelets that was previously found to be associated with other platelet traits. These findings suggest that EV formation is not a simple, constant adjunct of metabolism but is under both age-related and genetic control that can be independent of the regulation of the levels of the cells from which the EVs derive. - Source: PubMed
Publication date: 2023/04/13
Orrù ValeriaVirdis FrancescaMarongiu MicheleSerra ValentinaSchlessinger DavidDevoto MarcellaCucca FrancescoFiorillo Edoardo - Multi-walled carbon nanotube (MWCNT) is one of the most momentous carbonaceous nanoparticles which is widely used for various applications such as electronics, vehicles, and therapeutics. However, their possible toxicity and adverse effects convert them into a major health threat for humans and animals. - Source: PubMed
Publication date: 2022/02/17
Salih Shameran JamalGhobadi Mohadeseh Zarei - Cullin-RING ligases (CRLs) recognize and interact with substrates for ubiquitination and degradation, and can be targeted for disease treatment when the abnormal expression of substrates involves pathologic processes. Phosphorylation, either of substrates or receptors of CRLs, can alter their interaction. Phosphorylation-dependent ubiquitination and proteasome degradation influence various cellular processes and can contribute to the occurrence of various diseases, most often tumorigenesis. These processes have the potential to be used for tumor intervention through the regulation of the activities of related kinases, along with the regulation of the stability of specific oncoproteins and tumor suppressors. This review describes the mechanisms and biological functions of crosstalk between phosphorylation and ubiquitination, and most importantly its influence on tumorigenesis, to provide new directions and strategies for tumor therapy. - Source: PubMed
Publication date: 2020/09/19
Chen YifanShao XuejingCao JiZhu HongYang BoHe QiaojunYing Meidan