Ask about this productRelated genes to: SLC6A8 Blocking Peptide
- Gene:
- SLC6A8 NIH gene
- Name:
- solute carrier family 6 member 8
- Previous symbol:
- -
- Synonyms:
- CRTR, CT1
- Chromosome:
- Xq28
- Locus Type:
- gene with protein product
- Date approved:
- 1994-12-19
- Date modifiied:
- 2016-02-17
Related products to: SLC6A8 Blocking Peptide
Related articles to: SLC6A8 Blocking Peptide
- Does the human placenta utilize the creatine phosphagen system for energy homeostasis during development? - Source: PubMed
Publication date: 2026/05/07
Sah NirvayZheng ClaireShaik WaleeStein Frances HRajupalem RachanaMeads MorganPizzo DonaldSoncin Francesca - X-linked intellectual disability (XLID) is a well-recognized group of neurodevelopmental disorders, with pathogenic variants in X-chromosomal genes accounting for approximately 16% of intellectual disability cases in males. Clinical expression in females is variable and depends on patterns of X-chromosome inactivation. We describe three affected individuals from a single family with XLID caused by a confirmed duplication of the Xq28 region, including the genes , and . Two male siblings presented with severe phenotypes, including profound intellectual disability, severe speech impairment, behavioral issues, facial dysmorphism, spastic cerebral palsy, epilepsy, and cutaneous abnormalities. Their mother showed mild intellectual disability and skin manifestations. Family history suggested additional affected male relatives with a similar or even more severe clinical presentation. The duplication of multiple dosage-sensitive genes within the Xq28 region likely explains the multisystem involvement and the marked phenotypic variability observed between male and female family members. This report highlights the importance of considering Xq28 duplication, the most common X-linked copy number variation associated with intellectual disability, in the differential diagnosis of families with X-linked intellectual disability, especially if it is accompanied by additional neurological impairment. - Source: PubMed
Publication date: 2026/04/22
Gaberova KaterinaPacheva Iliyana HristovaYordanova RalitsaTodorov TihomirTodorova AlbenaGrozdanova LiliyanaPanova MargaritaGeorgieva MariyanaIvanov Ivan Stefanov - Dendritic cells (DCs) are central regulators of antitumor T cell immunity and are highly sensitive to metabolic cues. However, the therapeutic potential of targeting DC metabolism remains underexplored. Here, we report upregulation of the creatine transporter (; in intratumoral DCs, which facilitates the cellular uptake of creatine, an energy-storage metabolite. DCs from knockout mice exhibited impaired activation and reduced ability to elicit antigen-specific CD8 T cell responses. Conversely, creatine supplementation enhanced mouse DC activation and , and suppressed tumor growth in a syngeneic melanoma model. Notably, creatine uptake similarly boosted the activation and immunostimulatory function of human monocyte-derived DCs. Mechanistically, CrT promotes DC activation by preserving intracellular ATP levels and enhancing energy-dependent inflammatory signaling pathways. Together, these findings uncover a previously unrecognized role for creatine metabolism in regulating DC function and support the use of creatine supplementation as a strategy to augment DC-based cancer immunotherapy. - Source: PubMed
Publication date: 2026/03/21
Kang ElliotElsten-Brown JamesWang Yu-ChenLam AshleySanchez EliseWen ReneeWang TiffanyChiang JenniferScarborough QuentinLi Yan-RuideZhu YichenHuang JieWilliams MatthewEckl SarahLi BoYang Lili - The traditional Chinese medicine formula Rougan Tongluo Decoction (RGTL) was widely used to treat neurological injury after cerebral ischemia, though its specific underlying mechanisms remain unknown. This study investigates the mechanisms via which RGTL helps alleviate cerebral ischemic injury to provide theoretical support for its application in cerebral ischemia treatment. - Source: PubMed
Ou ChangzeBai Zheng-PingHu Guo-HengChen BinbinWu Da-HuaLong Hua-Jun - Although peripheral-brain crosstalk regulates energy metabolism, its role in depression remains unclear. Here, we used metabolic profiling to reveal elevated fecal creatine alongside reduced plasma and cerebrospinal fluid creatine in both patients with depression and mouse depression models. Exogenous creatine produced antidepressant-like effects mediated by gut microbiota. Bifidobacterium pseudolongum was identified as a significantly reduced gut bacterial species in depression, correlating with impaired creatine absorption. Subsequent supplementation with Bifidobacterium enhanced the antidepressant effects of creatine. Mechanistically, B. pseudolongum-derived acetate promoted the creatine transporter (Slc6a8) expression in intestinal epithelial cells via histone acetylation. The Slc6a8 mediated the antidepressant-like effects of creatine. Neuronal creatine deficiency influenced energetic metabolism and neurophysiological function. In patients with depression taking antidepressants, co-administration of creatine and Bifidobacterium increased plasma creatine levels and reduced depression scores. These findings identify the Bifidobacterium-creatine combination as a promising antidepressant strategy and highlight the critical role of gut-brain energy metabolism in depression. - Source: PubMed
Publication date: 2026/03/31
Lu Cheng-LinRen JingLei YueshiyuanLian Xiao-YingJiang Hao-TianGuo FangChen Liang-YuMo Jia-WenMao HongyunFan JunWu GuangyanYe Wan-QianWen You-LuSun HaitaoHe YanZhao JiuboCao Xiong