SCOTIN Blocking Peptide
- Known as:
- SCOTIN Blocking Peptide
- Catalog number:
- 33r-1648
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- SCOTIN Blocking Peptide
Related genes to: SCOTIN Blocking Peptide
- Gene:
- SHISA5 NIH gene
- Name:
- shisa family member 5
- Previous symbol:
- -
- Synonyms:
- SCOTIN, hShisa5
- Chromosome:
- 3p21.31
- Locus Type:
- gene with protein product
- Date approved:
- 2008-04-01
- Date modifiied:
- 2014-11-19
Related products to: SCOTIN Blocking Peptide
Related articles to: SCOTIN Blocking Peptide
- Eating disorder (ED) and obsessive-compulsive disorder (OCD) exhibit clinical and genetic overlap, yet whether they converge at the molecular level in the human brain is unknown. We perform large-scale transcriptomic profiling of the dorsolateral prefrontal cortex (DLPFC) and caudate in postmortem tissue from 86 controls, 57 individuals with ED, and 27 with OCD. ED shows robust, region-specific transcriptional dysregulation (102 differentially expressed genes [DEGs] in DLPFC and 222 in caudate at FDR <1%) that replicates in an independent cohort. OCD shows no single-cohort DEGs, but meta-analysis across three datasets identifies 57 caudate-associated genes. Despite these differences, transcriptome-wide effects strongly correlate between ED and OCD (DLPFC r = 0.67; caudate r = 0.75), indicating shared molecular pathology. Joint ED + OCD analysis identifies 233 DEGs in DLPFC and 815 in caudate, implicating GABAergic signaling, neuroendocrine regulation, mitochondrial metabolism, and CHD8-associated networks. Genetically regulated expression analyses identifies five genes (WDR6, NCKIPSD, P4HTM, DALRD3, and SHISA5) with convergent risk associations across disorders and brain regions, all mapping to a gene-dense region on chromosome 3. These findings define a shared cortico-striatal transcriptional architecture and identify candidate genes for transdiagnostic intervention. - Source: PubMed
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