Ask about this productRelated genes to: LRRTM1 Blocking Peptide
- Gene:
- LRRTM1 NIH gene
- Name:
- leucine rich repeat transmembrane neuronal 1
- Previous symbol:
- -
- Synonyms:
- FLJ32082
- Chromosome:
- 2p12
- Locus Type:
- gene with protein product
- Date approved:
- 2004-06-22
- Date modifiied:
- 2014-11-18
Related products to: LRRTM1 Blocking Peptide
Related articles to: LRRTM1 Blocking Peptide
- Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder characterized by the simultaneous disruption of interconnected molecular pathways, yet the structural mechanisms underlying this transcriptional disintegration remain poorly characterized. To address this, we constructed condition-specific gene co-expression networks from DLPFC bulk RNA-seq data, using a mutual-information (MI) framework with infomap community partitioning. Functional enrichment of network communities via Ingenuity Pathway Analysis (IPA) identified GABAergic signaling, SNARE complex assembly, Synaptogenesis, and neurexin and neuroligin interactions as significantly overrepresented pathways. Integration of node degree with condition-specific average expression revealed coordinated topological centralization of key synaptic genes-including NRXN2, LRRTM1, DLGAP3, and SHANK1-alongside a widespread transcriptional downregulation in GABAergic and Synaptogenesis modules. A shortest-path analysis revealed a consistent expansion of intra-pathway distances across all evaluated canonical pathways in AD, a pattern statistically consistent with reduced local co-expression cohesion. These findings reframe Late-Onset Alzheimer's Disease (LOAD) as an active structural-rewiring process, in which the observed topological centralization pattern seems to be consistent with a consolidation of co-expression around synaptic components, though we cannot exclude that shifts in cellular composition contribute to this signal in bulk RNA-seq data. - Source: PubMed
Publication date: 2026/05/27
Pinta-Castro AlejandroMichel-Ureña GabrielaPérez-González Alejandra PaulinaDe Anda-Jáuregui GuillermoHernández-Lemus Enrique - The central nervous system responds to acute injury with plastic remodeling of its network. However, the temporal and structural dynamics of this response in the denervated dentate gyrus remain poorly understood. Therefore, we examined the transcriptional programs activated after perforant path transection, focusing on the outer molecular layer (OML) and the granule cell layer (GCL). - Source: PubMed
Publication date: 2026/05/19
Schlaudraff JessicaDel Turco DomenicoKey JanaDeller ThomasAuburger Georg - Sinonasal tumours are rare entities presenting with non-specific symptoms, therefore being often misinterpreted. The present study aimed to evaluate if the 13-gene DNA Methylation assay for early cancer detection already assessed in the oral cavity, was also useful in nasal cavity tumours. The case series consisted of 93 patients (63 males/30 females), 49 with malignant tumours, 14 with benign/borderline tumours, 34 as control series with 33 inflammatory polyps and one fungus ball. We collected one flocked swab from the lesion and one from the contralateral nasal cavity. All sinonasal cancer cases were evaluated by bisulfite next generation DNA sequencing, investigating the following genes: ZAP70, ITGA4, KIF1A, PARP15, EPHX3, NTM, LRRTM1, FLI1, MIR193, LINC00599, MIR296, TERT, GP1BB. To evaluate the performance of the methylation assay, a specific methylation score was calculated for each sample using linear discriminant analysis, with a predefined positivity threshold of 1.0615547. The association between diagnosis and methylation score positivity was evaluated through Fisher's exact test and calculation of risk ratios with 95% confidence intervals. Additionally, dimensionality reduction techniques were employed to explore the structure of the dataset and assess the ability of methylation profiles to distinguish between different pathological conditions. The 13-gene DNA Methylation scored positive in 42/49 malignant tumours; We included also 14 benign/borderline tumours of which 11 scored positive. Among 33 inflammatory polyps, 24 scored negative, as well as 64/70 normal contralateral mucosa and one fungus ball. Therefore, excluding benign/borderline tumours, the detected sensitivity was 85.7% and specificity 85.6% (AUC: 0.878). - Source: PubMed
Publication date: 2026/01/29
Morandi LucaFarneti PaoloLeucci Anna CaterinaQuerzoli GiuliaMelotti SofiaCamagni AngelaGalli PaoloSollini GiacomoFranchi AlessandroTonon CaterinaLodi RaffaelePasquini ErnestoFoschini Maria Pia - Previous observational studies have indicated a significant correlation between plasma proteome composition and cataract pathological status; however, the direction of causality remains uncertain. In light of the aforementioned findings, the present study employs a bidirectional two-sample Mendelian randomisation strategy, with the objective of elucidating the direct causal link between plasma proteome changes and cataract development. Following rigorous data analysis and validation, a series of plasma proteins were identified as being strongly associated with cataract risk. These included ILF3, FAM171A1, ARHGEF2, LPR1B, CRYGD, GLT8D1, ARHGEF10 and LRRTM1, all of which were confirmed to be potential risk factors for cataract. In contrast, proteins such as MXRA7, ZHX3, SPAG11B, ARID1A, DNASE1L2, COX7A1 and EEF2K were found to exert a protective effect against cataract. To gain further insight into the specific mechanisms by which these causally related proteins contribute to cataract pathology, we subsequently performed an exhaustive bioinformatics analysis. This analysis not only deepened our understanding of the functional properties of these proteins, but also revealed their possible involvement in signalling pathways and molecular interactions, thereby providing new insights into the pathogenesis of cataract. - Source: PubMed
Publication date: 2025/12/17
Han XuanWang JinyanSu XiaojuanGuo XingyuYe Hejiang - Pyrethroid pesticides have been associated with neurodevelopmental disorders including attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). While behavioral effects of pyrethroid exposure have been previously reported, the underlying mechanisms remain unclear. Here, we hypothesized that exposure to deltamethrin (DM), a widely used pyrethroid pesticide known for its neurotoxicity during early developmental stages, induces brain dysfunction through alterations in brain-derived extracellular vesicle (BDEV) signaling. Using a well-established rodent model of early life DM exposure within the recommended no observable effect level, we isolated BDEVs from postnatal 30-day-old vehicle-exposed (control) and DM-exposed mice using a differential sucrose density gradient. Following ZetaView nanoparticle tracking and electron microscopy characterization, quantitative mass spectrometry-based proteomics revealed 89 differentially expressed proteins (DEPs) in BDEVs from DM exposed animals compared to control BDEVs. Bioinformatic analysis identified convergence of DEPs on pathways associated with mitochondrial function and synaptic plasticity. PKH67-green conjugated BDEVs derived from either control or DM-exposed mice were bilaterally injected intracerebroventricularly into naive adult mice, and the brain distribution of labeled BDEVs was verified prior to extracellular field recording experiments. Strikingly, long-term potentiation (LTP) at CA3-CA1 hippocampal synapses, a functional correlate of learning and memory, was intact in control BDEVs but absent in naive mice receiving BDEVs from DM exposed mice. Notably, exogenously delivering LRRTM1, one of the DEPs found in DM BDEVs, disrupts synaptic transmission in CA1 neurons consistent with impaired LTP. Thus, differentially regulated signaling in BDEVs represents a novel mechanism of DM neurotoxicity. - Source: PubMed
Publication date: 2024/12/31
Koff LeandraDi Re JessicaChand SubhashAvchalumov YosefNguyen Nghi MBaumgartner Timothy JSingh Aditya KGoode Nana AMarosi MateHallberg Lance MAmeredes Bill TGreen Thomas AYelamanchili Sowmya VPendyala GuruduttLaezza Fernanda