Ask about this productRelated genes to: UQCRC1 Blocking Peptide
- Gene:
- UQCRC1 NIH gene
- Name:
- ubiquinol-cytochrome c reductase core protein 1
- Previous symbol:
- -
- Synonyms:
- D3S3191, QCR1, UQCR1
- Chromosome:
- 3p21.31
- Locus Type:
- gene with protein product
- Date approved:
- 1993-07-09
- Date modifiied:
- 2017-09-12
Related products to: UQCRC1 Blocking Peptide
Related articles to: UQCRC1 Blocking Peptide
- - Source: PubMed
Publication date: 2026/08/05
Wu JianhaiLi HaoranWu ChongyingWu YunziYu HuangdaoChen Zhigang - Our study aims to explore the early genomic diagnostic markers of OSA and the corresponding drug prediction targets using network pharmacology analysis, and to elucidate the etiology and pathogenesis of OSA from the genetic level. - Source: PubMed
Xie FengweiZhu DikunYang ZhitongSun JieHuang TaoXian QianGuo DingyuLin YuyinSong LingyueZhong MingLiu YimingYuan TianhuangPang LingpinSun Xishi - Glioblastoma (GBM) is the most aggressive primary brain tumor in adults and is characterized by poor prognosis and marked molecular heterogeneity. Mitochondrial ribosomal proteins have emerged as regulators of cancer metabolism, yet the clinical significance of MRPL23 in GBM remains unclear. This study aimed to evaluate the prognostic relevance of MRPL23 expression in glioblastoma and its association with patient survival and mitochondrial functional profiles. - Source: PubMed
Publication date: 2026/07/10
Durślewicz JustynaZdrenka MarekSzylberg ŁukaszBorowczak Jędrzej - Mitochondrial dysfunction in colonic smooth muscle cells (SMCs) is closely associated with impaired gut motility in functional constipation (FC), but the underlying molecular mechanisms remain incompletely understood. The mitochondrial unfolded protein response (UPR) is a critical pathway for maintaining mitochondrial proteostasis, and heat shock factor 1 (HSF1) acts as an important upstream regulator of this response. In the present study, we employed a loperamide-induced FC mouse model, combined with single-cell transcriptomic, molecular, and functional analyses to characterize the HSF1-UPR pathway in colonic SMCs and to investigate its role in FC. Single-cell transcriptomic analysis of colon tissue from FC mice revealed marked downregulation of UPR-associated genes in colonic SMCs. Immunofluorescence, Western blotting, and RT-qPCR analyses of colonic tissue confirmed that HSF1 expression was reduced in colonic SMCs, along with the downregulation of the UPR components, including HSP60, mtHSP70, and LONP1. These molecular changes were accompanied by mitochondrial structural damage, seen by transmission electron microscopy, and by functional impairments, including reduced mitochondrial membrane potential, elevated mtROS production, decreased ATP levels, and diminished activities of respiratory chain complexes I-V. AAV9-mediated overexpression of HSF1 reactivated the UPR pathway, improved mitochondrial function, and ameliorated constipation, whereas shRNA-mediated knockdown of HSF1 further suppressed UPR activity and aggravated mitochondrial damage, indicating that HSF1 bidirectionally regulates this pathway. Complementary experiments in primary colonic SMCs confirmed that this regulatory mechanism operates in a cell-autonomous manner, as modulation of HSF1 expression produced corresponding changes in the UPR pathway, in the expression of mitochondrial respiratory chain complex subunits (ATP5A, NDUFA9, COX1, SDHA, UQCRC1), and in ATP production, mirroring the in vivo findings. Collectively, these results demonstrate that HSF1 plays a pivotal role in maintaining mitochondrial homeostasis in colonic SMCs through regulation of the UPR pathway and that HSF1 dysfunction is closely associated with slowed gut motility in FC. These findings offer a new mechanistic perspective on FC and point to the HSF1-UPR axis as a potential therapeutic target. - Source: PubMed
Publication date: 2026/06/12
Yao JunpengWang WenZhang WeiDong HangHou YujunZheng QianhuaLi YingZeng Fang - Mitochondrial proteases are essential for mitochondrial protein import and constitute the core of the organelle's intrinsic protein quality control system. However, their physiological functions across tissues, as well as their influence on cytosolic proteostasis, remain incompletely understood. - Source: PubMed
Publication date: 2026/06/19
Shi KexinLiu HaoXu HongShang WeinaWang LiquanTong Chao